Literature DB >> 19155295

The transcriptional corepressor CtBP: a foe of multiple tumor suppressors.

G Chinnadurai1.   

Abstract

CtBP1 and CtBP2 are closely related and evolutionarily conserved transcriptional corepressors. There is strong evidence linking CtBPs to tumorigenesis and tumor progression. CtBPs promote epithelial-mesenchymal transition and function as apoptosis antagonists. Also, CtBPs mediate repression of several tumor suppressor genes. Certain tumor suppressors also target CtBPs to restrain their tumor-promoting activity. Down-regulation of CtBPs mediated by some tumor suppressors results in p53-independent apoptosis and reduced tumor cell migration and invasion. The role of CtBPs in modulating the activities of different tumor suppressors is reviewed here. The results discussed here suggest that CtBPs may constitute a novel p53-independent anticancer target.

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Year:  2009        PMID： 19155295      PMCID： PMC4367538          DOI： 10.1158/0008-5472.CAN-08-3349

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  35 in total

1.  Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis.

Authors:  Maria Escrivà; Sandra Peiró; Nicolás Herranz; Patricia Villagrasa; Natàlia Dave; Bàrbara Montserrat-Sentís; Stephen A Murray; Clara Francí; Thomas Gridley; Ismo Virtanen; Antonio García de Herreros
Journal:  Mol Cell Biol       Date:  2008-01-02       Impact factor: 4.272

2.  The expression levels of the transcriptional regulators p300 and CtBP modulate the correlations between SNAIL, ZEB1, E-cadherin and vitamin D receptor in human colon carcinomas.

Authors:  Cristina Peña; José Miguel García; Vanesa García; Javier Silva; Gemma Domínguez; Rufo Rodríguez; Constanza Maximiano; Antonio García de Herreros; Alberto Muñoz; Félix Bonilla
Journal:  Int J Cancer       Date:  2006-11-01       Impact factor: 7.396

3.  C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs.

Authors:  Madeleine Grooteclaes; Quinn Deveraux; Jeffrey Hildebrand; Qinghong Zhang; Richard H Goodman; Steven M Frisch
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-03       Impact factor: 11.205

4.  c-Jun NH2-terminal kinase promotes apoptosis by down-regulating the transcriptional co-repressor CtBP.

Authors:  Su-Yan Wang; Mihail Iordanov; Qinghong Zhang
Journal:  J Biol Chem       Date:  2006-09-18       Impact factor: 5.157

5.  Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence.

Authors:  J J M Cowger; Q Zhao; M Isovic; J Torchia
Journal:  Oncogene       Date:  2006-11-27       Impact factor: 9.867

6.  Hdm2 recruits a hypoxia-sensitive corepressor to negatively regulate p53-dependent transcription.

Authors:  Alexander H Mirnezami; Sandra J Campbell; Matthew Darley; John N Primrose; Peter W M Johnson; Jeremy P Blaydes
Journal:  Curr Biol       Date:  2003-07-15       Impact factor: 10.834

7.  Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP.

Authors:  Qinghong Zhang; Yasuhiro Yoshimatsu; Jeffrey Hildebrand; Steven M Frisch; Richard H Goodman
Journal:  Cell       Date:  2003-10-17       Impact factor: 41.582

8.  p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding protein.

Authors:  Ya-Wen Chen; Seema Paliwal; Kyle Draheim; Steven R Grossman; Brian C Lewis
Journal:  Cancer Res       Date:  2008-01-15       Impact factor: 12.701

9.  Multiple loci identified in a genome-wide association study of prostate cancer.

Authors:  Gilles Thomas; Kevin B Jacobs; Meredith Yeager; Peter Kraft; Sholom Wacholder; Nick Orr; Kai Yu; Nilanjan Chatterjee; Robert Welch; Amy Hutchinson; Andrew Crenshaw; Geraldine Cancel-Tassin; Brian J Staats; Zhaoming Wang; Jesus Gonzalez-Bosquet; Jun Fang; Xiang Deng; Sonja I Berndt; Eugenia E Calle; Heather Spencer Feigelson; Michael J Thun; Carmen Rodriguez; Demetrius Albanes; Jarmo Virtamo; Stephanie Weinstein; Fredrick R Schumacher; Edward Giovannucci; Walter C Willett; Olivier Cussenot; Antoine Valeri; Gerald L Andriole; E David Crawford; Margaret Tucker; Daniela S Gerhard; Joseph F Fraumeni; Robert Hoover; Richard B Hayes; David J Hunter; Stephen J Chanock
Journal:  Nat Genet       Date:  2008-02-10       Impact factor: 38.330

10.  Antioncogenic effect of adenovirus E1A in human tumor cells.

Authors:  S M Frisch
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-15       Impact factor: 11.205
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  119 in total

1.  Conserved catalytic and C-terminal regulatory domains of the C-terminal binding protein corepressor fine-tune the transcriptional response in development.

Authors:  Yang W Zhang; David N Arnosti
Journal:  Mol Cell Biol       Date:  2010-11-15       Impact factor: 4.272

2.  PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1.

Authors:  Yasuko Ono; Shun-Ichiro Iemura; Stefanie M Novak; Naoko Doi; Fujiko Kitamura; Tohru Natsume; Carol C Gregorio; Hiroyuki Sorimachi
Journal:  J Mol Biol       Date:  2013-05-21       Impact factor: 5.469

3.  Integrative genetic, epigenetic and pathological analysis of paraganglioma reveals complex dysregulation of NOTCH signaling.

Authors:  Alessandro Cama; Fabio Verginelli; Lavinia Vittoria Lotti; Francesco Napolitano; Annalisa Morgano; Andria D'Orazio; Michele Vacca; Silvia Perconti; Felice Pepe; Federico Romani; Francesca Vitullo; Filippo di Lella; Rosa Visone; Massimo Mannelli; Hartmut P H Neumann; Giancarlo Raiconi; Carlo Paties; Antonio Moschetta; Roberto Tagliaferri; Angelo Veronese; Mario Sanna; Renato Mariani-Costantini
Journal:  Acta Neuropathol       Date:  2013-08-18       Impact factor: 17.088

4.  Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design.

Authors:  Brendan J Hilbert; Steven R Grossman; Celia A Schiffer; William E Royer
Journal:  FEBS Lett       Date:  2014-03-19       Impact factor: 4.124

5.  Assembly of human C-terminal binding protein (CtBP) into tetramers.

Authors:  Andrew G Bellesis; Anne M Jecrois; Janelle A Hayes; Celia A Schiffer; William E Royer
Journal:  J Biol Chem       Date:  2018-04-26       Impact factor: 5.157

6.  Expanding roles of ZEB factors in tumorigenesis and tumor progression.

Authors:  Ester Sánchez-Tilló; Laura Siles; Oriol de Barrios; Miriam Cuatrecasas; Eva C Vaquero; Antoni Castells; Antonio Postigo
Journal:  Am J Cancer Res       Date:  2011-08-20       Impact factor: 6.166

7.  ZEB1 and TCF4 reciprocally modulate their transcriptional activities to regulate Wnt target gene expression.

Authors:  E Sánchez-Tilló; O de Barrios; E Valls; D S Darling; A Castells; A Postigo
Journal:  Oncogene       Date:  2015-09-21       Impact factor: 9.867

8.  Role of transcriptional corepressor CtBP1 in prostate cancer progression.

Authors:  Rui Wang; Irfan A Asangani; Balabhadrapatruni V S K Chakravarthi; Bushra Ateeq; Robert J Lonigro; Qi Cao; Ram-Shankar Mani; Daniel F Camacho; Natalie McGregor; Taibriana E W Schumann; Xiaojun Jing; Radhika Menawat; Scott A Tomlins; Heng Zheng; Arie P Otte; Rohit Mehra; Javed Siddiqui; Saravana M Dhanasekaran; Mukesh K Nyati; Kenneth J Pienta; Nallasivam Palanisamy; Lakshmi P Kunju; Mark A Rubin; Arul M Chinnaiyan; Sooryanarayana Varambally
Journal:  Neoplasia       Date:  2012-10       Impact factor: 5.715

Review 9.  Deconstructing repression: evolving models of co-repressor action.

Authors:  Valentina Perissi; Kristen Jepsen; Christopher K Glass; Michael G Rosenfeld
Journal:  Nat Rev Genet       Date:  2010-02       Impact factor: 53.242

10.  Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1.

Authors:  Min Li; Suzette Riddle; Hui Zhang; Angelo D'Alessandro; Amanda Flockton; Natalie J Serkova; Kirk C Hansen; Radu Moldovan; B Alexandre McKeon; Maria Frid; Sushil Kumar; Hong Li; Hongbing Liu; Angela Caánovas; Juan F Medrano; Milton G Thomas; Dijana Iloska; Lydie Plecitá-Hlavatá; Petr Ježek; Soni Pullamsetti; Mehdi A Fini; Karim C El Kasmi; QingHong Zhang; Kurt R Stenmark
Journal:  Circulation       Date:  2016-08-25       Impact factor: 29.690
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