Literature DB >> 27157269

Characterization of nucleocytoplasmic shuttling and intracellular localization signals in Duck Enteritis Virus UL54.

Chaoyue Liu1, Anchun Cheng2, Mingshu Wang3, Shun Chen1, Renyong Jia1, Dekang Zhu4, Mafeng Liu1, Kunfeng Sun1, Qiao Yang1, Xiaoyue Chen4.   

Abstract

Duck Enteritis virus (DEV) UL54 is a homolog of herpes simplex virus-1 (HSV-1) trafficking protein ICP27, which plays an essential role in infection. In this study, DEV UL54 shuttling between the nucleus and cytoplasm was verified with a heterokaryon assay. One predicted nuclear export sequence (NES) (339-348 aa) was shown to be functional and chromosomal region maintenance 1 (CRM1)-dependent; however, the insensitivity of UL54 to Leptomycin B (LMB) and NES mutation suggests that other mechanisms are responsible for the observed nuclear export. Next, three non-classical nuclear localization sequences (NLSs), referred to as NLS1 (105-122 aa), NLS2 (169-192 aa) and NLS3 (257-274 aa), were identified. Furthermore, a recombinant DEV with the UL54 NLSs deleted (DEV- UL54 mNLSs) was constructed and showed that UL54 NLSs moderately affected DEV growth.
Copyright © 2016 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.

Entities:  

Keywords:  DEV; Nuclear export signal; Nuclear localization signal; Shuttling; UL54

Mesh：

Substances：

Year:  2016        PMID： 27157269     DOI： 10.1016/j.biochi.2016.05.003

Source DB:  PubMed          Journal:  Biochimie        ISSN： 0300-9084            Impact factor:   4.079


  9 in total

1.  US10 Protein Is Crucial but not Indispensable for Duck Enteritis Virus Infection in Vitro.

Authors:  Yunchao Ma; Qiurui Zeng; Mingshu Wang; Anchun Cheng; Renyong Jia; Qiao Yang; Ying Wu; Xin-Xin Zhao; Mafeng Liu; Dekang Zhu; Shun Chen; Shaqiu Zhang; Yunya Liu; Yanling Yu; Ling Zhang; Xiaoyue Chen
Journal:  Sci Rep       Date:  2018-11-07       Impact factor: 4.379

2.  The Pivotal Roles of US3 Protein in Cell-to-Cell Spread and Virion Nuclear Egress of Duck Plague Virus.

Authors:  Liyao Deng; Mingshu Wang; Anchun Cheng; Qiao Yang; Ying Wu; Renyong Jia; Shun Chen; Dekang Zhu; Mafeng Liu; Xinxin Zhao; Shaqiu Zhang; Juan Huang; Xumin Ou; Sai Mao; Ling Zhang; Yunya Liu; Yanling Yu; Bin Tian; Leichang Pan; Mujeeb Ur Rehman; Xiaoyue Chen
Journal:  Sci Rep       Date:  2020-04-28       Impact factor: 4.379

3.  Two nuclear localization signals regulate intracellular localization of the duck enteritis virus UL13 protein.

Authors:  Linjiang Yang; Xixia Hu; Anchun Cheng; Mingshu Wang; Renyong Jia; Qiao Yang; Ying Wu; Shun Chen; Mafeng Liu; Dekang Zhu; Xumin Ou; XingJian Wen; Sai Mao; Di Sun; Shaqiu Zhang; Xinxin Zhao; Juan Huang; Qun Gao; Yunya Liu; Yanling Yu; Ling Zhang; Bin Tian; Leichang Pan; Xiaoyue Chen
Journal:  Poult Sci       Date:  2020-10-08       Impact factor: 3.352

4.  The LORF5 Gene Is Non-essential for Replication but Important for Duck Plague Virus Cell-to-Cell Spread Efficiently in Host Cells.

Authors:  Bingjie Shen; Yunjiao Li; Anchun Cheng; Mingshu Wang; Ying Wu; Qiao Yang; Renyong Jia; Bin Tian; Xumin Ou; Sai Mao; Di Sun; Shaqiu Zhang; Dekang Zhu; Shun Chen; Mafeng Liu; Xin-Xin Zhao; Juan Huang; Qun Gao; Yunya Liu; Yanling Yu; Ling Zhang; Leichang Pan
Journal:  Front Microbiol       Date:  2021-12-02       Impact factor: 5.640

5.  Duck enteritis virus (DEV) UL54 protein, a novel partner, interacts with DEV UL24 protein.

Authors:  Xinghong Gao; Renyong Jia; Mingshu Wang; Qiao Yang; Shun Chen; Mafeng Liu; Zhongqiong Yin; Anchun Cheng
Journal:  Virol J       Date:  2017-08-29       Impact factor: 4.099

6.  Regulation of viral gene expression by duck enteritis virus UL54.

Authors:  Chaoyue Liu; Anchun Cheng; Mingshu Wang; Shun Chen; Renyong Jia; Dekang Zhu; Mafeng Liu; Kunfeng Sun; Qiao Yang; Ying Wu; Xinxin Zhao; Xiaoyue Chen
Journal:  Sci Rep       Date:  2017-04-21       Impact factor: 4.379

7.  Duck Enteritis Virus VP16 Antagonizes IFN-β-Mediated Antiviral Innate Immunity.

Authors:  Yang Li; Mingshu Wang; Anchun Cheng; Renyong Jia; Qiao Yang; Shun Chen; Dekang Zhu; Mafeng Liu; Xinxin Zhao; Shaqiu Zhang; Juan Huang; Xumin Ou; Sai Mao; Yanling Yu; Ling Zhang; Yunya Liu; Leichang Pan; Bin Tian; Mujeeb Ur Rehman; Xiaoyue Chen
Journal:  J Immunol Res       Date:  2020-05-15       Impact factor: 4.818

8.  Duplicate US1 Genes of Duck Enteritis Virus Encode a Non-essential Immediate Early Protein Localized to the Nucleus.

Authors:  Yangguang Li; Ying Wu; Mingshu Wang; YunChao Ma; Renyong Jia; Shun Chen; Dekang Zhu; Mafeng Liu; Qiao Yang; Xinxin Zhao; Shaqiu Zhang; Juan Huang; Xumin Ou; Sai Mao; Ling Zhang; Yunya Liu; Yanling Yu; Leichang Pan; Bin Tian; Mujeeb Ur Rehman; Xiaoyue Chen; Anchun Cheng
Journal:  Front Cell Infect Microbiol       Date:  2020-01-17       Impact factor: 5.293

9.  Duck enteritis virus pUL47, as a late structural protein localized in the nucleus, mainly depends on residues 40 to 50 and 768 to 777 and inhibits IFN-β signalling by interacting with STAT1.

Authors:  Tianqiong He; Mingshu Wang; Anchun Cheng; Qiao Yang; Renyong Jia; Ying Wu; Juan Huang; Shun Chen; Xin-Xin Zhao; Mafeng Liu; Dekang Zhu; Shaqiu Zhang; Xuming Ou; Sai Mao; Qun Gao; Di Sun; XinJian Wen; Bin Tian; Yunya Liu; Yanling Yu; Ling Zhang; Leichang Pan; Xiaoyue Chen
Journal:  Vet Res       Date:  2020-11-11       Impact factor: 3.683
  9 in total

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