Xiaodan Wang1, Jiayuan Hao2, Fuli Zhang1, Jing Li1, Huijuan Kong1, Yihong Guo3. 1. Reproductive Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China. 2. Reproductive Medicine Center, Hainan Provincial Nongken General Hospital, Haikou, People's Republic of China. 3. Reproductive Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China. Electronic address: 13613863710@163.com.
Abstract
OBJECTIVE: To investigate the combined effects of Chinese couples' body mass indices (BMIs) on the outcomes of IVF or intracytoplasmic sperm injection (ICSI) and the clinical characteristics of their neonates. DESIGN: Retrospective cohort study. SETTING: University-affiliated reproductive medicine center. PATIENT(S): A total of 12,061 first fresh IVF/ICSI cycles with autologous oocytes from September 1, 2009 to December 31, 2014. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The primary treatment outcome was live birth, and the primary outcome for the neonates was neonatal birth weight (NBW). RESULT(S): After adjusting for confounders, our study showed that in IVF cycles, couples with a female BMI ≥25 kg/m(2) had a significantly higher odds of abortion and a significantly lower odds of live birth than couples with both male and female BMIs <25 kg/m(2). Regarding ICSI cycles, no significant relationship was found between the couples' BMIs and the live birth rate. The NBWs of singletons conceived via IVF/ICSI cycles was significantly higher when their parents' BMIs were greater; however, no significant differences were observed in the NBWs of twins conceived via IVF/ICSI cycles. CONCLUSION(S): Increased female BMI negatively affected live births conceived via IVF. Regarding ICSI, no significant differences were found in the outcomes in terms of parental BMI. The singleton neonates' NBWs increased with parental BMI conceived via IVF/ICSI. However, parental BMI did not significantly affect the NBWs of twins conceived via IVF/ICSI.
OBJECTIVE: To investigate the combined effects of Chinese couples' body mass indices (BMIs) on the outcomes of IVF or intracytoplasmic sperm injection (ICSI) and the clinical characteristics of their neonates. DESIGN: Retrospective cohort study. SETTING: University-affiliated reproductive medicine center. PATIENT(S): A total of 12,061 first fresh IVF/ICSI cycles with autologous oocytes from September 1, 2009 to December 31, 2014. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The primary treatment outcome was live birth, and the primary outcome for the neonates was neonatal birth weight (NBW). RESULT(S): After adjusting for confounders, our study showed that in IVF cycles, couples with a female BMI ≥25 kg/m(2) had a significantly higher odds of abortion and a significantly lower odds of live birth than couples with both male and female BMIs <25 kg/m(2). Regarding ICSI cycles, no significant relationship was found between the couples' BMIs and the live birth rate. The NBWs of singletons conceived via IVF/ICSI cycles was significantly higher when their parents' BMIs were greater; however, no significant differences were observed in the NBWs of twins conceived via IVF/ICSI cycles. CONCLUSION(S): Increased female BMI negatively affected live births conceived via IVF. Regarding ICSI, no significant differences were found in the outcomes in terms of parental BMI. The singleton neonates' NBWs increased with parental BMI conceived via IVF/ICSI. However, parental BMI did not significantly affect the NBWs of twins conceived via IVF/ICSI.