Pengfei Qu1,2,3, Doudou Zhao1,2, Yang Mi4, Shaonong Dang5, Juanzi Shi6,7, Wenhao Shi8,9. 1. Translational Medicine Center, Northwest Women's and Children's Hospital, Xi'an, 710061, Shaanxi, People's Republic of China. 2. Assisted Reproduction Center, Northwest Women's and Children's Hospital, Xi'an, 710003, Shaanxi, People's Republic of China. 3. Departments of Pediatrics and Neonatology, Children's Hospital of Fudan University, Shanghai, People's Republic of China. 4. Department of obstetrics, Northwest Women's and Children's Hospital, Xi'an, 710003, Shaanxi, People's Republic of China. 5. Department of Epidemiology and Health Statistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, Shaanxi, People's Republic of China. 6. Translational Medicine Center, Northwest Women's and Children's Hospital, Xi'an, 710061, Shaanxi, People's Republic of China. shijuanzi123@126.com. 7. Assisted Reproduction Center, Northwest Women's and Children's Hospital, Xi'an, 710003, Shaanxi, People's Republic of China. shijuanzi123@126.com. 8. Translational Medicine Center, Northwest Women's and Children's Hospital, Xi'an, 710061, Shaanxi, People's Republic of China. swihao@yeah.net. 9. Assisted Reproduction Center, Northwest Women's and Children's Hospital, Xi'an, 710003, Shaanxi, People's Republic of China. swihao@yeah.net.
Abstract
BACKGROUND/ OBJECTIVES: To examine the effect of pre-pregnancy maternal body mass index (BMI) on neonatal weight outcomes of twin infants who were conceived by assisted reproductive technology (ART). SUBJECTS/ METHODS: A 10-year (2006-2015) Chinese sample of 3431 mothers and their twin infants conceived by ART from a retrospective cohort were included. The effects of pre-pregnancy maternal BMI on gestational age and birth weight were assessed by generalized linear model and generalized estimating equation model. RESULTS: Compared with a normal weight group, pre-pregnancy maternal underweight was associated with lower birth weight and increased risk of small for gestational age (SGA) in twins conceived by ART (birth weight: difference -59.22 g, 95% CI -93.16 to -25.27 g; SGA: RR 1.25, 95% CI 1.09 to 1.43). Pre-pregnancy maternal obesity was associated with higher birth weight and increased risk of preterm birth (birth weight: difference 65.82 g, 95% CI 10.66 to 120.99 g; preterm birth: RR 1.19, 95% CI 1.03-1.37). A nonlinear relationship between pre-pregnancy maternal BMI and SGA was observed. The risk of SGA decreased with the pre-pregnancy maternal BMI up to the turning point (BMI = 21) (RR 0.90, 95% CI 0.86-0.95). CONCLUSIONS: Among mothers undergoing ART, pre-pregnancy maternal obesity is associated with higher birth weight and higher risk of preterm birth for twin pregnancy, and pre-pregnancy maternal underweight is associated with lower birth weight and higher risk of SGA. Women preparing for ART should maintain a normal BMI to lower the chances of adverse neonatal outcomes.
BACKGROUND/ OBJECTIVES: To examine the effect of pre-pregnancy maternal body mass index (BMI) on neonatal weight outcomes of twin infants who were conceived by assisted reproductive technology (ART). SUBJECTS/ METHODS: A 10-year (2006-2015) Chinese sample of 3431 mothers and their twin infants conceived by ART from a retrospective cohort were included. The effects of pre-pregnancy maternal BMI on gestational age and birth weight were assessed by generalized linear model and generalized estimating equation model. RESULTS: Compared with a normal weight group, pre-pregnancy maternal underweight was associated with lower birth weight and increased risk of small for gestational age (SGA) in twins conceived by ART (birth weight: difference -59.22 g, 95% CI -93.16 to -25.27 g; SGA: RR 1.25, 95% CI 1.09 to 1.43). Pre-pregnancy maternal obesity was associated with higher birth weight and increased risk of preterm birth (birth weight: difference 65.82 g, 95% CI 10.66 to 120.99 g; preterm birth: RR 1.19, 95% CI 1.03-1.37). A nonlinear relationship between pre-pregnancy maternal BMI and SGA was observed. The risk of SGA decreased with the pre-pregnancy maternal BMI up to the turning point (BMI = 21) (RR 0.90, 95% CI 0.86-0.95). CONCLUSIONS: Among mothers undergoing ART, pre-pregnancy maternal obesity is associated with higher birth weight and higher risk of preterm birth for twin pregnancy, and pre-pregnancy maternal underweight is associated with lower birth weight and higher risk of SGA. Women preparing for ART should maintain a normal BMI to lower the chances of adverse neonatal outcomes.
Authors: Aniket D Kulkarni; Eli Y Adashi; Denise J Jamieson; Sara B Crawford; Saswati Sunderam; Dmitry M Kissin Journal: Paediatr Perinat Epidemiol Date: 2017-08-01 Impact factor: 3.980
Authors: Ch De Geyter; C Calhaz-Jorge; M S Kupka; C Wyns; E Mocanu; T Motrenko; G Scaravelli; J Smeenk; S Vidakovic; V Goossens Journal: Hum Reprod Date: 2018-09-01 Impact factor: 6.918
Authors: Saswati Sunderam; Dmitry M Kissin; Sara B Crawford; Suzanne G Folger; Sheree L Boulet; Lee Warner; Wanda D Barfield Journal: MMWR Surveill Summ Date: 2018-02-16