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Literature DB >> 27154744

GPER-novel membrane oestrogen receptor.

Margaret A Zimmerman¹, Rebecca A Budish¹, Shreya Kashyap¹, Sarah H Lindsey².

Abstract

The recent discovery of the G protein-coupled oestrogen receptor (GPER) presents new challenges and opportunities for understanding the physiology, pathophysiology and pharmacology of many diseases. This review will focus on the expression and function of GPER in hypertension, kidney disease, atherosclerosis, vascular remodelling, heart failure, reproduction, metabolic disorders, cancer, environmental health and menopause. Furthermore, this review will highlight the potential of GPER as a therapeutic target.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: GPR30; cancer; cardiovascular; menopause; metabolism; reproduction

Mesh：

Substances：

Year: 2016 PMID： 27154744 PMCID： PMC5125080 DOI： 10.1042/CS20160114

Source DB: PubMed Journal: Clin Sci (Lond) ISSN： 0143-5221 Impact factor: 6.124

159 in total

1. A novel estrogen receptor GPER inhibits mitochondria permeability transition pore opening and protects the heart against ischemia-reperfusion injury.

Authors: Jean Chrisostome Bopassa; Mansoureh Eghbali; Ligia Toro; Enrico Stefani
Journal: Am J Physiol Heart Circ Physiol Date: 2009-10-30 Impact factor: 4.733

Review 2. Copernicus Revisited: Overturning Ptolemy's View of the GPER Universe.

Authors: Ross D Feldman; Lee E Limbird
Journal: Trends Endocrinol Metab Date: 2015-10-16 Impact factor: 12.015

3. The nuclear localization signal is required for nuclear GPER translocation and function in breast Cancer-Associated Fibroblasts (CAFs).

Authors: Marco Pupo; Adele Vivacqua; Ida Perrotta; Assunta Pisano; Saveria Aquila; Sergio Abonante; Anna Gasperi-Campani; Vincenzo Pezzi; Marcello Maggiolini
Journal: Mol Cell Endocrinol Date: 2013-06-05 Impact factor: 4.102

4. GPR30 activation opposes estrogen-dependent uterine growth via inhibition of stromal ERK1/2 and estrogen receptor alpha (ERα) phosphorylation signals.

Authors: Fei Gao; Xinghong Ma; Alicia B Ostmann; Sanjoy K Das
Journal: Endocrinology Date: 2011-02-08 Impact factor: 4.736

5. Expression pattern of G protein-coupled receptor 30 in LacZ reporter mice.

Authors: Jörg Isensee; Luca Meoli; Valeria Zazzu; Christoph Nabzdyk; Henning Witt; Dian Soewarto; Karin Effertz; Helmut Fuchs; Valérie Gailus-Durner; Dirk Busch; Thure Adler; Martin Hrabé de Angelis; Markus Irgang; Christiane Otto; Patricia Ruiz Noppinger
Journal: Endocrinology Date: 2008-12-18 Impact factor: 4.736

6. G protein-coupled estrogen receptor inhibits vascular prostanoid production and activity.

Authors: Matthias R Meyer; Natalie C Fredette; Matthias Barton; Eric R Prossnitz
Journal: J Endocrinol Date: 2015-08-24 Impact factor: 4.286

7. Estrogen-eluting, phosphorylcholine-coated stent implantation is associated with reduced neointimal formation but no delay in vascular repair in a porcine coronary model.

Authors: Gishel New; Jeffrey W Moses; Gary S Roubin; Martin B Leon; Antonio Colombo; Sriram S Iyer; Fermin O Tio; Roxana Mehran; Nicholas Kipshidze
Journal: Catheter Cardiovasc Interv Date: 2002-10 Impact factor: 2.692

8. Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteries.

Authors: Brad R S Broughton; Alyson A Miller; Christopher G Sobey
Journal: Am J Physiol Heart Circ Physiol Date: 2010-01-08 Impact factor: 4.733

9. Vasodilation by GPER in mesenteric arteries involves both endothelial nitric oxide and smooth muscle cAMP signaling.

Authors: Sarah H Lindsey; Liu Liu; Mark C Chappell
Journal: Steroids Date: 2013-11-16 Impact factor: 2.668

10. The activation of G protein-coupled receptor 30 (GPR30) inhibits proliferation of estrogen receptor-negative breast cancer cells in vitro and in vivo.

Authors: W Wei; Z-J Chen; K-S Zhang; X-L Yang; Y-M Wu; X-H Chen; H-B Huang; H-L Liu; S-H Cai; J Du; H-S Wang
Journal: Cell Death Dis Date: 2014-10-02 Impact factor: 8.469

41 in total

1. Impaired estrogen signaling underlies regulatory T cell loss-of-function in the chronically inflamed intestine.

Authors: Wendy A Goodman; Sarah M Bedoyan; Hannah L Havran; Brian Richardson; Mark J Cameron; Theresa T Pizarro
Journal: Proc Natl Acad Sci U S A Date: 2020-07-06 Impact factor: 11.205

2. Role of GPER in estrogen-dependent nitric oxide formation and vasodilation.

Authors: Natalie C Fredette; Matthias R Meyer; Eric R Prossnitz
Journal: J Steroid Biochem Mol Biol Date: 2017-05-18 Impact factor: 4.292

3. A nongenomic mechanism for "metalloestrogenic" effects of cadmium in human uterine leiomyoma cells through G protein-coupled estrogen receptor.

Authors: Jingli Liu; Linda Yu; Lysandra Castro; Yitang Yan; Maria I Sifre; Carl D Bortner; Darlene Dixon
Journal: Arch Toxicol Date: 2019-08-29 Impact factor: 5.153

Review 4. Sex differences in mechanisms of arterial stiffness.

Authors: Jennifer J DuPont; Rachel M Kenney; Ayan R Patel; Iris Z Jaffe
Journal: Br J Pharmacol Date: 2019-05-11 Impact factor: 8.739

Review 5. Estrogen and thrombosis: A bench to bedside review.

Authors: Mouhamed Yazan Abou-Ismail; Divyaswathi Citla Sridhar; Lalitha Nayak
Journal: Thromb Res Date: 2020-05-11 Impact factor: 3.944

6. Cardiomyocyte-specific deletion of the G protein-coupled estrogen receptor (GPER) leads to left ventricular dysfunction and adverse remodeling: A sex-specific gene profiling analysis.

Authors: Hao Wang; Xuming Sun; Jeff Chou; Marina Lin; Carlos M Ferrario; Gisele Zapata-Sudo; Leanne Groban
Journal: Biochim Biophys Acta Mol Basis Dis Date: 2016-10-08 Impact factor: 5.187

10. Metabotropic glutamate receptor subtype 5 (mGlu₅) is necessary for estradiol mitigation of light-induced anxiety behavior in female rats.

Authors: Christiana K Miller; Amanda A Krentzel; Heather B Patisaul; John Meitzen
Journal: Physiol Behav Date: 2019-12-09