Literature DB >> 26482875

Copernicus Revisited: Overturning Ptolemy's View of the GPER Universe.

Ross D Feldman1, Lee E Limbird2.   

Abstract

Whether aldosterone activates the G-protein-coupled estrogen receptor (GPER) has been questioned, recently, in the name of Copernicus. However, for G-protein-coupled receptors (GPCRs) multiple hormone activators are common. Further, studies in mineralocorticoid receptor (MR)-deficient systems, with pharmacological GPER-selective antagonists or regulation of GPER expression, consistently show that some aldosterone effects can be GPER mediated.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  GPCR; GPER; aldosterone; estrogen

Mesh：

Substances：

Year:  2015        PMID： 26482875     DOI： 10.1016/j.tem.2015.09.002

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  6 in total

Review 1.  GPER-novel membrane oestrogen receptor.

Authors:  Margaret A Zimmerman; Rebecca A Budish; Shreya Kashyap; Sarah H Lindsey
Journal:  Clin Sci (Lond)       Date:  2016-06-01       Impact factor: 6.124

2.  Rapid Aldosterone-Mediated Signaling in the DCT Increases Activity of the Thiazide-Sensitive NaCl Cotransporter.

Authors:  Lei Cheng; Søren Brandt Poulsen; Qi Wu; Cristina Esteva-Font; Emma T B Olesen; Li Peng; Björn Olde; L M Fredrik Leeb-Lundberg; Trairak Pisitkun; Timo Rieg; Henrik Dimke; Robert A Fenton
Journal:  J Am Soc Nephrol       Date:  2019-06-28       Impact factor: 10.121

Review 3.  Genomic and rapid effects of aldosterone: what we know and do not know thus far.

Authors:  Milla Marques Hermidorff; Leonardo Vinícius Monteiro de Assis; Mauro César Isoldi
Journal:  Heart Fail Rev       Date:  2017-01       Impact factor: 4.214

Review 4.  The Interface of Nuclear and Membrane Steroid Signaling.

Authors:  Lindsey S Treviño; Daniel A Gorelick
Journal:  Endocrinology       Date:  2021-08-01       Impact factor: 4.736

5.  GPER is involved in the stimulatory effects of aldosterone in breast cancer cells and breast tumor-derived endothelial cells.

Authors:  Damiano Cosimo Rigiracciolo; Andrea Scarpelli; Rosamaria Lappano; Assunta Pisano; Maria Francesca Santolla; Silvia Avino; Paola De Marco; Benedetta Bussolati; Marcello Maggiolini; Ernestina Marianna De Francesco
Journal:  Oncotarget       Date:  2016-01-05

6.  Extracellular matrix induced by steroids and aging through a G-protein-coupled receptor in a Drosophila model of renal fibrosis.

Authors:  Wenjing Zheng; Karen Ocorr; Marc Tatar
Journal:  Dis Model Mech       Date:  2020-06-24       Impact factor: 5.732
  6 in total

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