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Literature DB >> 27152252

PTH Signaling and Epigenetic Control of Bone Remodeling.

Florante Ricarte¹, Teruyo Nakatani², Nicola Partridge³.

Abstract

As our understanding of the mechanisms that govern bone development advance, the role of epigenetic modifications in these processes become increasingly evident. Interestingly, in parathyroid hormone (PTH)-induced bone metabolism and remodeling, recent evidence shows that PTH signaling employs a particular facet of the epigenetic machinery to elicit its desired effects. In this review, we briefly discuss the known epigenetic events occurring in cells of the osteoblast lineage. More specifically, we elaborate on current findings that reveal the utilization of histone deacetylating enzymes (HDACs) in PTH-regulated modulation of gene expression in bone.

Entities: Chemical Disease Gene Species

Keywords: HDAC; PTH; bone remodeling; transcriptional regulation

Year: 2016 PMID： 27152252 PMCID： PMC4853160 DOI： 10.1007/s40610-016-0033-7

Source DB: PubMed Journal: Curr Mol Biol Rep ISSN： 2198-6428

75 in total

1. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation.

Authors: Donald A Glass; Peter Bialek; Jong Deok Ahn; Michael Starbuck; Millan S Patel; Hans Clevers; Mark M Taketo; Fanxin Long; Andrew P McMahon; Richard A Lang; Gerard Karsenty
Journal: Dev Cell Date: 2005-05 Impact factor: 12.270

Review 2. Functions of site-specific histone acetylation and deacetylation.

Authors: Mona D Shahbazian; Michael Grunstein
Journal: Annu Rev Biochem Date: 2007 Impact factor: 23.643

3. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide.

Authors: H Jüppner; A B Abou-Samra; M Freeman; X F Kong; E Schipani; J Richards; L F Kolakowski; J Hock; J T Potts; H M Kronenberg
Journal: Science Date: 1991-11-15 Impact factor: 47.728

4. The Proteasome Inhibitor Carfilzomib Suppresses Parathyroid Hormone-induced Osteoclastogenesis through a RANKL-mediated Signaling Pathway.

Authors: Yanmei Yang; Harry C Blair; Irving M Shapiro; Bin Wang
Journal: J Biol Chem Date: 2015-05-15 Impact factor: 5.157

5. Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.

Authors: Jong Seok Kang; Tamara Alliston; Rachel Delston; Rik Derynck
Journal: EMBO J Date: 2005-06-30 Impact factor: 11.598

6. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts.

Authors: T Komori; H Yagi; S Nomura; A Yamaguchi; K Sasaki; K Deguchi; Y Shimizu; R T Bronson; Y H Gao; M Inada; M Sato; R Okamoto; Y Kitamura; S Yoshiki; T Kishimoto
Journal: Cell Date: 1997-05-30 Impact factor: 41.582

7. Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation.

Authors: Tania M Schroeder; Rachel A Kahler; Xiaodong Li; Jennifer J Westendorf
Journal: J Biol Chem Date: 2004-08-02 Impact factor: 5.157

PTH Signaling and Epigenetic Control of Bone Remodeling.

1. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation.

Review 2. Functions of site-specific histone acetylation and deacetylation.

3. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide.

4. The Proteasome Inhibitor Carfilzomib Suppresses Parathyroid Hormone-induced Osteoclastogenesis through a RANKL-mediated Signaling Pathway.

5. Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.

6. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts.

7. Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation.

8. Class I and IIa histone deacetylases have opposite effects on sclerostin gene regulation.

Review 9. Conserved metabolic regulatory functions of sirtuins.

10. Expression of the Runt domain-encoding PEBP2 alpha genes in T cells during thymic development.

1. Mussel-Inspired Multifunctional Hydrogel Coating for Prevention of Infections and Enhanced Osteogenesis.

Review 2. CCL2/Monocyte Chemoattractant Protein 1 and Parathyroid Hormone Action on Bone.