Literature DB >> 27152172

Thermogenic potential and physiological relevance of human epicardial adipose tissue.

K Chechi1, D Richard1.   

Abstract

Epicardial adipose tissue is a unique fat depot around the heart that shares a close anatomic proximity and vascular supply with the myocardium and coronary arteries. Its accumulation around the heart, measured using various imaging modalities, has been associated with the onset and progression of coronary artery disease in humans. Epicardial adipose tissue is also the only fat depot around the heart that is known to express uncoupling protein 1 at both mRNA and protein levels in the detectable range. Recent advances have further indicated that human epicardial fat exhibits beige fat-like features. Here we provide an overview of the physiological and pathophysiological relevance of human epicardial fat, and further discuss whether its thermogenic properties can serve as a target for the therapeutic management of coronary heart disease in humans.

Entities:  

Year:  2015        PMID： 27152172      PMCID： PMC4850577          DOI： 10.1038/ijosup.2015.8

Source DB:  PubMed          Journal:  Int J Obes Suppl        ISSN： 2046-2166


  79 in total

1.  Porcine intrinsic cardiac ganglia.

Authors:  R C Arora; M Waldmann; D A Hopkins; J A Armour
Journal:  Anat Rec A Discov Mol Cell Evol Biol       Date:  2003-03

2.  Epicardial and pericardial fat: close, but very different.

Authors:  Gianluca Iacobellis
Journal:  Obesity (Silver Spring)       Date:  2009-04       Impact factor: 5.002

3.  Uncoupling protein-1 and related messenger ribonucleic acids in human epicardial and other adipose tissues: epicardial fat functioning as brown fat.

Authors:  Harold S Sacks; John N Fain; Ben Holman; Paramjeet Cheema; Aron Chary; Frank Parks; James Karas; Robert Optican; Suleiman W Bahouth; Edward Garrett; Rodney Y Wolf; Russell A Carter; Todd Robbins; David Wolford; Joseph Samaha
Journal:  J Clin Endocrinol Metab       Date:  2009-06-30       Impact factor: 5.958

4.  How brown is brown fat? It depends where you look.

Authors:  Jan Nedergaard; Barbara Cannon
Journal:  Nat Med       Date:  2013-05       Impact factor: 53.440

5.  Brown adipose tissue activity controls triglyceride clearance.

Authors:  Alexander Bartelt; Oliver T Bruns; Rudolph Reimer; Heinz Hohenberg; Harald Ittrich; Kersten Peldschus; Michael G Kaul; Ulrich I Tromsdorf; Horst Weller; Christian Waurisch; Alexander Eychmüller; Philip L S M Gordts; Franz Rinninger; Karoline Bruegelmann; Barbara Freund; Peter Nielsen; Martin Merkel; Joerg Heeren
Journal:  Nat Med       Date:  2011-01-23       Impact factor: 53.440

6.  Adipose tissue in the mammalian heart and pericardium: structure, foetal development and biochemical properties.

Authors:  J M Marchington; C A Mattacks; C M Pond
Journal:  Comp Biochem Physiol B       Date:  1989

7.  Pericardial fat is more abundant in patients with coronary atherosclerosis and even in the non-obese patients: evaluation with cardiac CT angiography.

Authors:  Hwan Seok Yong; Eung Ju Kim; Hong Seog Seo; Eun-Young Kang; Yun Kyung Kim; Ok Hee Woo; Heon Han
Journal:  Int J Cardiovasc Imaging       Date:  2010-02       Impact factor: 2.357

8.  Role of epicardial adipose tissue in coronary artery disease in non-obese patients.

Authors:  Tadateru Iwayama; Joji Nitobe; Tetsu Watanabe; Mitsunori Ishino; Harutoshi Tamura; Satoshi Nishiyama; Hiroki Takahashi; Takanori Arimoto; Tetsuro Shishido; Takehiko Miyashita; Takuya Miyamoto; Shuji Toyama; Mitsuaki Sadahiro; Isao Kubota
Journal:  J Cardiol       Date:  2013-11-11       Impact factor: 3.159

9.  Epicardial adipose tissue as a predictor of coronary artery disease in asymptomatic subjects.

Authors:  Gil N Bachar; Dror Dicker; Ran Kornowski; Eli Atar
Journal:  Am J Cardiol       Date:  2012-05-10       Impact factor: 2.778

Review 10.  Perivascular adipose tissue and its role in type 2 diabetes and cardiovascular disease.

Authors:  Rick I Meijer; Erik H Serne; Yvo M Smulders; Victor W M van Hinsbergh; John S Yudkin; Etto C Eringa
Journal:  Curr Diab Rep       Date:  2011-06       Impact factor: 4.810
View more
  11 in total

1.  UCP1 expression-associated gene signatures of human epicardial adipose tissue.

Authors:  Kanta Chechi; Jinchu Vijay; Pierre Voisine; Patrick Mathieu; Yohan Bossé; Andre Tchernof; Elin Grundberg; Denis Richard
Journal:  JCI Insight       Date:  2019-04-18

Review 2.  Epicardial and pericardial fat analysis on CT images and artificial intelligence: a literature review.

Authors:  Federico Greco; Rodrigo Salgado; Wim Van Hecke; Romualdo Del Buono; Paul M Parizel; Carlo Augusto Mallio
Journal:  Quant Imaging Med Surg       Date:  2022-03

3.  The Isolation and Culture of Primary Epicardial Cells Derived from Human Adult and Fetal Heart Specimens.

Authors:  Esther Dronkers; Asja T Moerkamp; Tessa van Herwaarden; Marie-José Goumans; Anke M Smits
Journal:  J Vis Exp       Date:  2018-04-24       Impact factor: 1.355

Review 4.  Investigating interactions between epicardial adipose tissue and cardiac myocytes: what can we learn from different approaches?

Authors:  Katja Rietdorf; Hilary MacQueen
Journal:  Br J Pharmacol       Date:  2017-01-22       Impact factor: 8.739

Review 5.  The Flexibility of Ectopic Lipids.

Authors:  Hannah Loher; Roland Kreis; Chris Boesch; Emanuel Christ
Journal:  Int J Mol Sci       Date:  2016-09-14       Impact factor: 5.923

6.  Susceptibilities of epicardial and subcutaneous fat tissue for browning-gene expression and diet-induced volume reduction are different.

Authors:  Hiroshi Mikamo; Meizi Jiang; Mahito Noro; Yasuo Suzuki; Nobuyuki Hiruta; Hiroyuki Unoki-Kubota; Wolfgang J Schneider; Hideaki Bujo
Journal:  Mol Med Rep       Date:  2018-03-06       Impact factor: 2.952

7.  Functional characterization of the Ucp1-associated oxidative phenotype of human epicardial adipose tissue.

Authors:  Kanta Chechi; Pierre Voisine; Patrick Mathieu; Mathieu Laplante; Sébastian Bonnet; Frédéric Picard; Philippe Joubert; Denis Richard
Journal:  Sci Rep       Date:  2017-11-14       Impact factor: 4.379

8.  Regulation of Brown Adipose Tissue Activity by Interoceptive CNS Pathways: The interaction between Brain and Periphery.

Authors:  Otto Muzik; Vaibhav A Diwadkar
Journal:  Front Neurosci       Date:  2017-11-16       Impact factor: 4.677

Review 9.  Hypothalamic control of brown adipose tissue thermogenesis.

Authors:  Sebastien M Labbé; Alexandre Caron; Damien Lanfray; Boris Monge-Rofarello; Timothy J Bartness; Denis Richard
Journal:  Front Syst Neurosci       Date:  2015-11-03

10.  Association of serum concentrations of irisin and the adipokines adiponectin and leptin with epicardial fat in cardiovascular surgery patients.

Authors:  Hiroyuki Kaneda; Toshiaki Nakajima; Akiko Haruyama; Ikuko Shibasaki; Takaaki Hasegawa; Tatsuya Sawaguchi; Toshiyuki Kuwata; Syoutarou Obi; Takuo Arikawa; Masashi Sakuma; Hirohisa Amano; Shigeru Toyoda; Hirotsugu Fukuda; Teruo Inoue
Journal:  PLoS One       Date:  2018-08-02       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.