Rebecca K West1, Ramit Ravona-Springer2, Anthony Heymann3, James Schmeidler4, Derek Leroith5, Keren Koifman2, Ryan C N D'Arcy6, Xiaowei Song6, Elizabeth Guerrero-Berroa7, Rachel Preiss2, Hadas Hoffman2, Mary Sano7, Jeremy M Silverman7, Michal Schnaider-Beeri8. 1. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: rebecca.west@mssm.edu. 2. The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Israel. 3. Maccabi Healthcare Services, Tel-Aviv, Israel; Department of Family Medicine, The Sackler School of Medicine Tel Aviv University, Tel Aviv, Israel. 4. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 5. Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 6. Simon Fraser University, Metro Vancouver, British Columbia, Canada; Surrey Memorial Hospital, Fraser Health, Metro Vancouver, British Columbia, Canada. 7. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA. 8. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Israel.
Abstract
INTRODUCTION: Waist circumference is associated with type 2 diabetes (T2D) and cognition, yet the relationship between waist circumference and cognition in individuals with T2D is not well understood. METHODS: We studied the relationship of waist circumference with five cognitive outcomes (executive functioning, language/semantic categorization, attention/working memory, episodic memory, and an overall cognition measure) in 845 cognitively normal elderly with type 2 diabetes (T2D). RESULTS: In women, waist circumference was correlated with significantly lower language and/or semantic categorization performance (P < .0001), executive functioning (P = .026), and overall cognition (P = .003) after controlling for age, education, BMI, and cardiovascular, diabetes-related, APOE ε4, and inflammatory potential confounders. Attention/working memory (P = .532) and episodic memory (P = .144) were not associated with waist circumference. These correlations were not found in men. DISCUSSION: These results suggest that central adiposity in elderly women with T2D may increase their risk for dementia.
INTRODUCTION: Waist circumference is associated with type 2 diabetes (T2D) and cognition, yet the relationship between waist circumference and cognition in individuals with T2D is not well understood. METHODS: We studied the relationship of waist circumference with five cognitive outcomes (executive functioning, language/semantic categorization, attention/working memory, episodic memory, and an overall cognition measure) in 845 cognitively normal elderly with type 2 diabetes (T2D). RESULTS: In women, waist circumference was correlated with significantly lower language and/or semantic categorization performance (P < .0001), executive functioning (P = .026), and overall cognition (P = .003) after controlling for age, education, BMI, and cardiovascular, diabetes-related, APOE ε4, and inflammatory potential confounders. Attention/working memory (P = .532) and episodic memory (P = .144) were not associated with waist circumference. These correlations were not found in men. DISCUSSION: These results suggest that central adiposity in elderly women with T2D may increase their risk for dementia.
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