Literature DB >> 27149279

YAP controls transcriptional elongation through CKD9 recruitment for proximal pause release: "Hippo-thetical", new therapeutic targets?

Fiorina Kyritsi1, Douglas K Price1, William D Figg1.   

Abstract

The Hippo-YAP signaling pathway has been established as a crucial regulator of tissue growth and tumorigenesis but the mechanism for transcriptional control remains unclear. In their study, Galli et al. show that YAP/TAZ binding is restricted to a small number of gene enhancers and that YAP/TAZ regulates transcriptional elongation by recruiting the Mediator complex.

Entities:  

Keywords:  Hippo/YAP pathway; YAP-bound regulatory elements; mediator complex; transcriptional elongation; tumorigenesis

Mesh：

Substances：

Year:  2016        PMID： 27149279      PMCID： PMC4990395          DOI： 10.1080/15384047.2016.1178883

Source DB:  PubMed          Journal:  Cancer Biol Ther        ISSN： 1538-4047            Impact factor:   4.742


  16 in total

Review 1.  The RNA polymerase II core promoter: a key component in the regulation of gene expression.

Authors:  Jennifer E F Butler; James T Kadonaga
Journal:  Genes Dev       Date:  2002-10-15       Impact factor: 11.361

Review 2.  The transition from transcriptional initiation to elongation.

Authors:  Joseph T Wade; Kevin Struhl
Journal:  Curr Opin Genet Dev       Date:  2008-02-20       Impact factor: 5.578

3.  Super-enhancers in the control of cell identity and disease.

Authors:  Denes Hnisz; Brian J Abraham; Tong Ihn Lee; Ashley Lau; Violaine Saint-André; Alla A Sigova; Heather A Hoke; Richard A Young
Journal:  Cell       Date:  2013-10-10       Impact factor: 41.582

4.  YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers.

Authors:  Giorgio G Galli; Matteo Carrara; Wei-Chien Yuan; Christian Valdes-Quezada; Basanta Gurung; Brian Pepe-Mooney; Tinghu Zhang; Geert Geeven; Nathanael S Gray; Wouter de Laat; Raffaele A Calogero; Fernando D Camargo
Journal:  Mol Cell       Date:  2015-10-01       Impact factor: 17.970

Review 5.  Regulation of the Hippo pathway and implications for anticancer drug development.

Authors:  Hyun Woo Park; Kun-Liang Guan
Journal:  Trends Pharmacol Sci       Date:  2013-09-16       Impact factor: 14.819

6.  The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation.

Authors:  Ian Lian; Joungmok Kim; Hideki Okazawa; Jiagang Zhao; Bin Zhao; Jindan Yu; Arul Chinnaiyan; Mason A Israel; Lawrence S B Goldstein; Ramzey Abujarour; Sheng Ding; Kun-Liang Guan
Journal:  Genes Dev       Date:  2010-06-01       Impact factor: 11.361

Review 7.  The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation.

Authors:  Sohail Malik; Robert G Roeder
Journal:  Nat Rev Genet       Date:  2010-10-13       Impact factor: 53.242

8.  Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP.

Authors:  Yi Liu-Chittenden; Bo Huang; Joong Sup Shim; Qian Chen; Se-Jin Lee; Robert A Anders; Jun O Liu; Duojia Pan
Journal:  Genes Dev       Date:  2012-06-07       Impact factor: 11.361

9.  Mediator requirement for both recruitment and postrecruitment steps in transcription initiation.

Authors:  Gang Wang; Michael A Balamotis; Jennitte L Stevens; Yuki Yamaguchi; Hiroshi Handa; Arnold J Berk
Journal:  Mol Cell       Date:  2005-03-04       Impact factor: 17.970

10.  The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis.

Authors:  Kieran F Harvey; Cathie M Pfleger; Iswar K Hariharan
Journal:  Cell       Date:  2003-08-22       Impact factor: 41.582
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