Literature DB >> 2714444

Distribution of serotonin 5-HT1C receptor mRNA in adult rat brain.

B J Hoffman1, E Mezey.   

Abstract

Based on in situ hybridization histochemistry (ISHH), we describe the anatomical distribution of the serotonin 5-HT1C receptor mRNA. In addition to the very high levels in epithelial cells of the choroid plexus, 5-HT1C receptor mRNA is found throughout the limbic system, in catecholaminergic cells and in serotonergic neurons. Receptor transcripts are also present in the hypothalamus, numerous motor nuclei and the subthalamus. Our results correlate well with serotonin (5-HT) innervation and receptor binding. Receptor mRNA is present in many brain structures in addition to regions previously shown to have 5-HT1C receptor binding. The distribution of this receptor mRNA suggests that the 5-HT1C receptor may mediate a number of the central effects of 5-HT.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2714444     DOI： 10.1016/0014-5793(89)81390-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  34 in total

1.  Serotonin 5-HT2C receptor protein expression is enriched in synaptosomal and post-synaptic compartments of rat cortex.

Authors:  Noelle C Anastasio; Maria Fe Lanfranco; Marcy J Bubar; Patricia K Seitz; Sonja J Stutz; Andrew G McGinnis; Cheryl S Watson; Kathryn A Cunningham
Journal:  J Neurochem       Date:  2010-03-24       Impact factor: 5.372

Review 2.  A short history of the 5-HT2C receptor: from the choroid plexus to depression, obesity and addiction treatment.

Authors:  Jose M Palacios; Angel Pazos; Daniel Hoyer
Journal:  Psychopharmacology (Berl)       Date:  2017-03-07       Impact factor: 4.530

Review 3.  Autoradiographical and immunohistochemical analysis of receptor localization in the central nervous system.

Authors:  J G Chabot; S Kar; R Quirion
Journal:  Histochem J       Date:  1996-11

4.  Meta-chlorophenylpiperazine enhances leptin sensitivity in diet-induced obese mice.

Authors:  Chunling Yan; Yongjie Yang; Kenji Saito; Pingwen Xu; Chunmei Wang; Antentor Othrell Hinton; Xiaofeng Yan; Qi Wu; Qingchun Tong; Joel K Elmquist; Makoto Fukuda; Yong Xu
Journal:  Br J Pharmacol       Date:  2015-05-11       Impact factor: 8.739

5.  Choroid plexus epithelial cells in primary culture: a model of 5HT1C receptor activation by hallucinogenic drugs.

Authors:  E Sanders-Bush; M Breeding
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

6.  A conserved asparagine residue in transmembrane segment 1 (TM1) of serotonin transporter dictates chloride-coupled neurotransmitter transport.

Authors:  L Keith Henry; Hideki Iwamoto; Julie R Field; Kristian Kaufmann; Eric S Dawson; Miriam T Jacobs; Chelsea Adams; Bruce Felts; Igor Zdravkovic; Vanessa Armstrong; Steven Combs; Ernesto Solis; Gary Rudnick; Sergei Y Noskov; Louis J DeFelice; Jens Meiler; Randy D Blakely
Journal:  J Biol Chem       Date:  2011-07-05       Impact factor: 5.157

Review 7.  Multiple controls exerted by 5-HT2C receptors upon basal ganglia function: from physiology to pathophysiology.

Authors:  P De Deurwaerdère; M Lagière; M Bosc; S Navailles
Journal:  Exp Brain Res       Date:  2013-04-25       Impact factor: 1.972

Review 8.  Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission.

Authors:  K D Alex; E A Pehek
Journal:  Pharmacol Ther       Date:  2006-10-17       Impact factor: 12.310

9.  Effects of serotonergic agents on apomorphine-induced locomotor activity.

Authors:  K A Young; R Zavodny; P B Hicks
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

10.  5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis.

Authors:  Yong Xu; Juli E Jones; Daisuke Kohno; Kevin W Williams; Charlotte E Lee; Michelle J Choi; Jason G Anderson; Lora K Heisler; Jeffrey M Zigman; Bradford B Lowell; Joel K Elmquist
Journal:  Neuron       Date:  2008-11-26       Impact factor: 17.173
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.