| Literature DB >> 27143445 |
Filipe Tenorio Lira Neto1, Phil Vu Bach1, Bobby B Najari1, Philip S Li1, Marc Goldstein2.
Abstract
Spermatogenesis is an extraordinary complex process. The differentiation of spermatogonia into spermatozoa requires the participation of several cell types, hormones, paracrine factors, genes and epigenetic regulators. Recent researches in animals and humans have furthered our understanding of the male gamete differentiation, and led to clinical tools for the better management of male infertility. There is still much to be learned about this intricate process. In this review, the critical steps of human spermatogenesis are discussed together with its main affecting factors. Copyright ÂEntities:
Keywords: Genetics; Germ cells; Human spermatogenesis; Male infertility; Reproduction; Sperm; Testis; Testosterone; Varicocele
Mesh:
Year: 2016 PMID: 27143445 DOI: 10.1016/j.semcdb.2016.04.009
Source DB: PubMed Journal: Semin Cell Dev Biol ISSN: 1084-9521 Impact factor: 7.727