Jeffrey M Engelmann1, Francesco Versace2, Jonathan C Gewirtz3, Paul M Cinciripini4. 1. Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, United States. Electronic address: jmengelmann@mdanderson.org. 2. Oklahoma Tobacco Research Center, Stephenson Cancer Center, and Department of Family & Preventive Medicine, University of Oklahoma Health Sciences Center, United States. 3. Department of Psychology, University of Minnesota, United States. 4. Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, United States.
Abstract
BACKGROUND: Decreased sensitivity to pleasant stimuli is associated with a higher vulnerability to nicotine dependence in youths and with difficulty quitting in adult smokers. Recently, we showed that smokers showing lower brain reactivity to non-cigarette-related pleasant images than to cigarette-related ones have lower chances of achieving long-term abstinence during a quit attempt. METHODS: We tested whether individual differences in brain responses to cigarette-related and pleasant stimuli require a long history of smoking to develop by measuring the late positive potential (LPP) to cigarette cues, emotional, and neutral stimuli in 45 young, light smokers (ages 18-25). k-means cluster analysis was used to partition smokers into two groups based on the magnitude of their LPPs. RESULTS: Group 1 was characterized by larger LPPs to pleasant pictures than cigarette-related pictures whereas Group 2 showed the opposite pattern. CONCLUSIONS: Our results suggest that individual differences in brain responses to cigarette-related and pleasant cues do not require a long smoking history to develop.
RCT Entities:
BACKGROUND: Decreased sensitivity to pleasant stimuli is associated with a higher vulnerability to nicotine dependence in youths and with difficulty quitting in adult smokers. Recently, we showed that smokers showing lower brain reactivity to non-cigarette-related pleasant images than to cigarette-related ones have lower chances of achieving long-term abstinence during a quit attempt. METHODS: We tested whether individual differences in brain responses to cigarette-related and pleasant stimuli require a long history of smoking to develop by measuring the late positive potential (LPP) to cigarette cues, emotional, and neutral stimuli in 45 young, light smokers (ages 18-25). k-means cluster analysis was used to partition smokers into two groups based on the magnitude of their LPPs. RESULTS: Group 1 was characterized by larger LPPs to pleasant pictures than cigarette-related pictures whereas Group 2 showed the opposite pattern. CONCLUSIONS: Our results suggest that individual differences in brain responses to cigarette-related and pleasant cues do not require a long smoking history to develop.
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