Literature DB >> 27141329

Lactic acid polarizes macrophages to a tumor-promoting state.

Oscar R Colegio1.   

Abstract

Tumor-associated macrophages have been associated with a poor prognosis in most types of tumors. However, tumor-derived signals that activate macrophages have not been well defined. We review our recent finding that tumor-derived lactic acid is necessary and sufficient to polarize tumor-associated macrophages to a tumor-promoting state.

Entities:  

Year:  2015        PMID： 27141329      PMCID： PMC4839384          DOI： 10.1080/2162402X.2015.1014774

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

1.  On the origin of cancer cells.

Authors:  O WARBURG
Journal:  Science       Date:  1956-02-24       Impact factor: 47.728

Review 2.  Immunity, inflammation, and cancer.

Authors:  Sergei I Grivennikov; Florian R Greten; Michael Karin
Journal:  Cell       Date:  2010-03-19       Impact factor: 41.582

Review 3.  Macrophage diversity enhances tumor progression and metastasis.

Authors:  Bin-Zhi Qian; Jeffrey W Pollard
Journal:  Cell       Date:  2010-04-02       Impact factor: 41.582

Review 4.  Tumors as organs: complex tissues that interface with the entire organism.

Authors:  Mikala Egeblad; Elizabeth S Nakasone; Zena Werb
Journal:  Dev Cell       Date:  2010-06-15       Impact factor: 12.270

5.  Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis.

Authors:  Huasheng Lu; Robert A Forbes; Ajay Verma
Journal:  J Biol Chem       Date:  2002-04-09       Impact factor: 5.157

Review 6.  Alternative activation of macrophages: mechanism and functions.

Authors:  Siamon Gordon; Fernando O Martinez
Journal:  Immunity       Date:  2010-05-28       Impact factor: 31.745

Review 7.  Trophic macrophages in development and disease.

Authors:  Jeffrey W Pollard
Journal:  Nat Rev Immunol       Date:  2009-04       Impact factor: 53.106

8.  Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis.

Authors:  D Shweiki; A Itin; D Soffer; E Keshet
Journal:  Nature       Date:  1992-10-29       Impact factor: 49.962

Review 9.  Cancer-related inflammation.

Authors:  Alberto Mantovani; Paola Allavena; Antonio Sica; Frances Balkwill
Journal:  Nature       Date:  2008-07-24       Impact factor: 49.962

10.  Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.

Authors:  Oscar R Colegio; Ngoc-Quynh Chu; Alison L Szabo; Thach Chu; Anne Marie Rhebergen; Vikram Jairam; Nika Cyrus; Carolyn E Brokowski; Stephanie C Eisenbarth; Gillian M Phillips; Gary W Cline; Andrew J Phillips; Ruslan Medzhitov
Journal:  Nature       Date:  2014-07-13       Impact factor: 69.504
  10 in total
  13 in total

Review 1.  Lactic acid alleviates stress: good for female genital tract homeostasis, bad for protection against malignancy.

Authors:  Steven S Witkin
Journal:  Cell Stress Chaperones       Date:  2017-10-23       Impact factor: 3.667

2.  Remodeling "cold" tumor immune microenvironment via epigenetic-based therapy using targeted liposomes with in situ formed albumin corona.

Authors:  Yang He; Yuefei Fang; Meng Zhang; Yuge Zhao; Bin Tu; Mingjie Shi; Bahtiyor Muhitdinov; Akmal Asrorov; Qin Xu; Yongzhuo Huang
Journal:  Acta Pharm Sin B       Date:  2021-09-30       Impact factor: 14.903

3.  Metabolism in tumor-associated macrophages.

Authors:  Jie Li; Gina M DeNicola; Brian Ruffell
Journal:  Int Rev Cell Mol Biol       Date:  2022-02-21       Impact factor: 6.420

4.  Polyamine Blocking Therapy Decreases Survival of Tumor-Infiltrating Immunosuppressive Myeloid Cells and Enhances the Antitumor Efficacy of PD-1 Blockade.

Authors:  Eric T Alexander; Kelsey Mariner; Julia Donnelly; Otto Phanstiel; Susan K Gilmour
Journal:  Mol Cancer Ther       Date:  2020-08-03       Impact factor: 6.261

Review 5.  The reciprocal function and regulation of tumor vessels and immune cells offers new therapeutic opportunities in cancer.

Authors:  Rindert Missiaen; Massimiliano Mazzone; Gabriele Bergers
Journal:  Semin Cancer Biol       Date:  2018-06-20       Impact factor: 15.707

Review 6.  Chemotherapy and tumor microenvironment of pancreatic cancer.

Authors:  Qiaofei Liu; Quan Liao; Yupei Zhao
Journal:  Cancer Cell Int       Date:  2017-07-05       Impact factor: 5.722

Review 7.  Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy.

Authors:  Seema Gupta; Amrita Roy; Bilikere S Dwarakanath
Journal:  Front Oncol       Date:  2017-04-12       Impact factor: 6.244

Review 8.  Metabolic Symbiosis and Immunomodulation: How Tumor Cell-Derived Lactate May Disturb Innate and Adaptive Immune Responses.

Authors:  Alexandre Morrot; Leonardo Marques da Fonseca; Eduardo J Salustiano; Luciana Boffoni Gentile; Luciana Conde; Alessandra Almeida Filardy; Tatiany Nunes Franklim; Kelli Monteiro da Costa; Celio Geraldo Freire-de-Lima; Leonardo Freire-de-Lima
Journal:  Front Oncol       Date:  2018-03-23       Impact factor: 6.244

Review 9.  From Friend to Enemy: Dissecting the Functional Alteration of Immunoregulatory Components during Pancreatic Tumorigenesis.

Authors:  Hui-Ching Wang; Wen-Chun Hung; Li-Tzong Chen; Mei-Ren Pan
Journal:  Int J Mol Sci       Date:  2018-11-13       Impact factor: 5.923

10.  Human keratinocyte carcinomas have distinct differences in their tumor-associated macrophages.

Authors:  Xiaodong Jiang; Mike Wang; Nika Cyrus; Diana A Yanez; Richard K Lacher; Anne Marie Rhebergen; Carolyn Brokowski; Anjela Galan; Samuel Book; Oscar R Colegio
Journal:  Heliyon       Date:  2019-08-13
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