Literature DB >> 20510870

Alternative activation of macrophages: mechanism and functions.

Siamon Gordon1, Fernando O Martinez.   

Abstract

The concept of an alternative pathway of macrophage activation has stimulated interest in its definition, mechanism, and functional significance in homeostasis and disease. We assess recent research in this field, argue for a restricted definition, and explore pathways by which the T helper 2 (Th2) cell cytokines interleukin-4 (IL-4) and IL-13 mediate their effects on macrophage cell biology, their biosynthesis, and responses to a normal and pathological microenvironment. The stage is now set to gain deeper insights into the role of alternatively activated macrophages in immunobiology. Copyright 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20510870     DOI： 10.1016/j.immuni.2010.05.007

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  1479 in total

1.  Protective role of NKT cells and macrophage M2-driven phenotype in bleomycin-induced pulmonary fibrosis.

Authors:  Felipe Grabarz; Cristhiane Favero Aguiar; Matheus Correa-Costa; Tárcio Teodoro Braga; Meire I Hyane; Vinícius Andrade-Oliveira; Maristella Almeida Landgraf; Niels Olsen Saraiva Câmara
Journal:  Inflammopharmacology       Date:  2017-08-04       Impact factor: 4.473

2.  Cutting edge: microRNA regulation of macrophage fusion into multinucleated giant cells.

Authors:  James R Sissons; Jacques J Peschon; Frank Schmitz; Rosa Suen; Mark Gilchrist; Alan Aderem
Journal:  J Immunol       Date:  2012-06-01       Impact factor: 5.422

3.  Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection.

Authors:  Simeone Marino; Nicholas A Cilfone; Joshua T Mattila; Jennifer J Linderman; JoAnne L Flynn; Denise E Kirschner
Journal:  Infect Immun       Date:  2014-11-03       Impact factor: 3.441

4.  Early macrophage recruitment and alternative activation are critical for the later development of hypoxia-induced pulmonary hypertension.

Authors:  Eleni Vergadi; Mun Seog Chang; Changjin Lee; Olin D Liang; Xianlan Liu; Angeles Fernandez-Gonzalez; S Alex Mitsialis; Stella Kourembanas
Journal:  Circulation       Date:  2011-04-25       Impact factor: 29.690

5.  Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11b(high)Gr1(low) macrophages.

Authors:  Gabriela Schiechl; Bernhard Bauer; Ivan Fuss; Sven A Lang; Christian Moser; Petra Ruemmele; Stefan Rose-John; Markus F Neurath; Edward K Geissler; Hans-Jürgen Schlitt; Warren Strober; Stefan Fichtner-Feigl
Journal:  J Clin Invest       Date:  2011-04-25       Impact factor: 14.808

6.  STING Activation Reverses Lymphoma-Mediated Resistance to Antibody Immunotherapy.

Authors:  Lekh N Dahal; Lang Dou; Khiyam Hussain; Rena Liu; Alexander Earley; Kerry L Cox; Salome Murinello; Ian Tracy; Francesco Forconi; Andrew J Steele; Patrick J Duriez; Diego Gomez-Nicola; Jessica L Teeling; Martin J Glennie; Mark S Cragg; Stephen A Beers
Journal:  Cancer Res       Date:  2017-05-16       Impact factor: 12.701

7.  Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitis.

Authors:  Yudong Liu; Andrew T Holdbrooks; Patrizia De Sarno; Amber L Rowse; Lora L Yanagisawa; Braden C McFarland; Laurie E Harrington; Chander Raman; Steffanie Sabbaj; Etty N Benveniste; Hongwei Qin
Journal:  J Immunol       Date:  2013-12-09       Impact factor: 5.422

8.  Depletion of GR-1-Positive Cells Is Associated with Reduced Neutrophil Inflammation and Astrocyte Reactivity after Experimental Intracerebral Hemorrhage.

Authors:  Matthew C Loftspring; Holly L Johnson; Aaron J Johnson; Joseph F Clark
Journal:  Transl Stroke Res       Date:  2012-05-02       Impact factor: 6.829

9.  Proteomic and bioinformatics profile of paired human alveolar macrophages and peripheral blood monocytes.

Authors:  Sara E Tomechko; Kathleen C Lundberg; Jessica Jarvela; Gurkan Bebek; Nicole G Chesnokov; Daniela Schlatzer; Rob M Ewing; W Henry Boom; Mark R Chance; Richard F Silver
Journal:  Proteomics       Date:  2015-11       Impact factor: 3.984

Review 10.  Pro- and anti-inflammatory cytokines in cutaneous leishmaniasis: a review.

Authors:  Nahid Maspi; Amir Abdoli; Fathemeh Ghaffarifar
Journal:  Pathog Glob Health       Date:  2016-09-23       Impact factor: 2.894
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