Literature DB >> 27135911

The Four Layers of Aging.

Ran Zhang1, Hou-Zao Chen2, De-Pei Liu3.   

Abstract

Instead of considering aging in terms of discrete hallmarks, we suggest that it operates in four layers, each at a different biological scale. Malfunctions within each layer-and connections between them-produce the aged phenotype and its associated susceptibility to disease.
Copyright © 2015 Elsevier Inc. All rights reserved.

Keywords:  Aging; adaptive response; age-related diseases; dietary/caloric restriction; evolutionary fitness

Year:  2015        PMID： 27135911     DOI： 10.1016/j.cels.2015.09.002

Source DB:  PubMed          Journal:  Cell Syst        ISSN： 2405-4712            Impact factor:   10.304


  23 in total

Review 1.  The Aging Epigenome.

Authors:  Lauren N Booth; Anne Brunet
Journal:  Mol Cell       Date:  2016-06-02       Impact factor: 17.970

2.  Asynchronous, contagious and digital aging.

Authors:  Thomas A Rando; Tony Wyss-Coray
Journal:  Nat Aging       Date:  2021-01-14

Review 3.  Epigenetic regulation in cell senescence.

Authors:  Li-Qin Cheng; Zhu-Qin Zhang; Hou-Zao Chen; De-Pei Liu
Journal:  J Mol Med (Berl)       Date:  2017-09-08       Impact factor: 4.599

4.  Ghrelin-mediated pathway in Apolipoprotein-E deficient mice: a survival system.

Authors:  Rita Rezzani; Caterina Franco; Gaia Favero; Luigi F Rodella
Journal:  Am J Transl Res       Date:  2019-07-15       Impact factor: 4.060

Review 5.  Targeting the "hallmarks of aging" to slow aging and treat age-related disease: fact or fiction?

Authors:  Maryam Keshavarz; Kan Xie; Kristina Schaaf; Daniele Bano; Dan Ehninger
Journal:  Mol Psychiatry       Date:  2022-07-15       Impact factor: 13.437

6.  Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm.

Authors:  Hou-Zao Chen; Fang Wang; Peng Gao; Jian-Fei Pei; Yue Liu; Ting-Ting Xu; Xiaoqiang Tang; Wen-Yan Fu; Jie Lu; Yun-Fei Yan; Xiao-Man Wang; Lei Han; Zhu-Qin Zhang; Ran Zhang; Ming-Hui Zou; De-Pei Liu
Journal:  Circ Res       Date:  2016-09-20       Impact factor: 17.367

Review 7.  Enhancer reprogramming in tumor progression: a new route towards cancer cell plasticity.

Authors:  Luca Fagnocchi; Vittoria Poli; Alessio Zippo
Journal:  Cell Mol Life Sci       Date:  2018-04-24       Impact factor: 9.261

8.  Comprehensive assessment of cellular senescence in the tumor microenvironment.

Authors:  Xiaoman Wang; Lifei Ma; Xiaoya Pei; Heping Wang; Xiaoqiang Tang; Jian-Fei Pei; Yang-Nan Ding; Siyao Qu; Zi-Yu Wei; Hui-Yu Wang; Xiaoyue Wang; Gong-Hong Wei; De-Pei Liu; Hou-Zao Chen
Journal:  Brief Bioinform       Date:  2022-05-13       Impact factor: 13.994

Review 9.  Influence of Age on Skeletal Muscle Hypertrophy and Atrophy Signaling: Established Paradigms and Unexpected Links.

Authors:  Eun-Joo Lee; Ronald L Neppl
Journal:  Genes (Basel)       Date:  2021-05-03       Impact factor: 4.096

10.  Novel regional age-associated DNA methylation changes within human common disease-associated loci.

Authors:  Christopher G Bell; Yudong Xia; Wei Yuan; Fei Gao; Kirsten Ward; Leonie Roos; Massimo Mangino; Pirro G Hysi; Jordana Bell; Jun Wang; Timothy D Spector
Journal:  Genome Biol       Date:  2016-09-23       Impact factor: 13.583
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