Literature DB >> 27134664

What goes around comes around: novel pharmacological targets in the gut-brain axis.

Camila González-Arancibia1, Jorge Escobar-Luna1, Camila Barrera-Bugueño1, Camilo Díaz-Zepeda1, María P González-Toro1, Loreto Olavarría-Ramírez1, Francesca Zanelli-Massai1, Martin Gotteland2, Javier A Bravo1, Marcela Julio-Pieper3.   

Abstract

The gut and the brain communicate bidirectionally through anatomic and humoral pathways, establishing what is known as the gut-brain axis. Therefore, interventions affecting one system will impact on the other, giving the opportunity to investigate and develop future therapeutic strategies that target both systems. Alterations in the gut-brain axis may arise as a consequence of changes in microbiota composition (dysbiosis), modifications in intestinal barrier function, impairment of enteric nervous system, unbalanced local immune response and exaggerated responses to stress, to mention a few. In this review we analyze and discuss several novel pharmacological targets within the gut-brain axis, with potential applications to improve intestinal and mental health.

Entities:  

Keywords:  enteric nervous system; gut–brain axis; interleukin 22; intestinal microbiota; serotonin; vagus nerve

Year:  2016        PMID： 27134664      PMCID： PMC4830101          DOI： 10.1177/1756283X16630718

Source DB:  PubMed          Journal:  Therap Adv Gastroenterol        ISSN： 1756-283X            Impact factor:   4.409


  108 in total

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3.  Psychological and physiological responses to postprandial mental stress in women with the irritable bowel syndrome.

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Review 6.  Role of serotonin in the pathophysiology of the irritable bowel syndrome.

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Authors:  Sophie Leclercq; Sébastien Matamoros; Patrice D Cani; Audrey M Neyrinck; François Jamar; Peter Stärkel; Karen Windey; Valentina Tremaroli; Fredrik Bäckhed; Kristin Verbeke; Philippe de Timary; Nathalie M Delzenne
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8.  Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses.

Authors:  Siobhain M O'Mahony; Julian R Marchesi; Paul Scully; Caroline Codling; Anne-Marie Ceolho; Eamonn M M Quigley; John F Cryan; Timothy G Dinan
Journal:  Biol Psychiatry       Date:  2008-08-23       Impact factor: 13.382

9.  The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress.

Authors:  Michael Lutter; Ichiro Sakata; Sherri Osborne-Lawrence; Sherry A Rovinsky; Jason G Anderson; Saendy Jung; Shari Birnbaum; Masashi Yanagisawa; Joel K Elmquist; Eric J Nestler; Jeffrey M Zigman
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2.  The Gut Microbiota of Healthy Chilean Subjects Reveals a High Abundance of the Phylum Verrucomicrobia.

Authors:  Sayaka Fujio-Vejar; Yessenia Vasquez; Pamela Morales; Fabien Magne; Patricia Vera-Wolf; Juan A Ugalde; Paola Navarrete; Martin Gotteland
Journal:  Front Microbiol       Date:  2017-06-30       Impact factor: 5.640

3.  Investigating Gut Permeability in Animal Models of Disease.

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Journal:  Front Physiol       Date:  2019-01-15       Impact factor: 4.566

Review 4.  Ethnic differences in genetic polymorphism associated with irritable bowel syndrome.

Authors:  Qi-Yun Xiao; Xiu-Cai Fang; Xiao-Qing Li; Gui-Jun Fei
Journal:  World J Gastroenterol       Date:  2020-05-07       Impact factor: 5.742

5.  Involvement of serotonergic pathways in gastric dysmotility induced by fat burning nutritional supplements in mice.

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Journal:  Curr Res Pharmacol Drug Discov       Date:  2021-02-05

6.  Comparative Analysis of the Impact of Urolithins on the Composition of the Gut Microbiota in Normal-Diet Fed Rats.

Authors:  Ali Khalaf Al Khalaf; Abdulrasheed O Abdulrahman; Mohammed Kaleem; Suza Mohammad Nur; Amer H Asseri; Hani Choudhry; Mohammad Imran Khan
Journal:  Nutrients       Date:  2021-10-29       Impact factor: 5.717

7.  Blocking the Hepatic Branch of the Vagus Aggravates Hepatic Ischemia-Reperfusion Injury via Inhibiting the Expression of IL-22 in the Liver.

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Journal:  J Immunol Res       Date:  2021-05-08       Impact factor: 4.818
  7 in total

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