Literature DB >> 18552842

The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress.

Michael Lutter1, Ichiro Sakata, Sherri Osborne-Lawrence, Sherry A Rovinsky, Jason G Anderson, Saendy Jung, Shari Birnbaum, Masashi Yanagisawa, Joel K Elmquist, Eric J Nestler, Jeffrey M Zigman.   

Abstract

We found that increasing ghrelin levels, through subcutaneous injections or calorie restriction, produced anxiolytic- and antidepressant-like responses in the elevated plus maze and forced swim test. Moreover, chronic social defeat stress, a rodent model of depression, persistently increased ghrelin levels, whereas growth hormone secretagogue receptor (Ghsr) null mice showed increased deleterious effects of chronic defeat. Together, these findings demonstrate a previously unknown function for ghrelin in defending against depressive-like symptoms of chronic stress.

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Year:  2008        PMID： 18552842      PMCID： PMC2765052          DOI： 10.1038/nn.2139

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  12 in total

Review 1.  Minireview: From anorexia to obesity--the yin and yang of body weight control.

Authors:  Jeffrey M Zigman; Joel K Elmquist
Journal:  Endocrinology       Date:  2003-09       Impact factor: 4.736

2.  Mice lacking ghrelin receptors resist the development of diet-induced obesity.

Authors:  Jeffrey M Zigman; Yoshihide Nakano; Roberto Coppari; Nina Balthasar; Jacob N Marcus; Charlotte E Lee; Juli E Jones; Amy E Deysher; Amanda R Waxman; Ryan D White; Todd D Williams; Jennifer L Lachey; Randy J Seeley; Bradford B Lowell; Joel K Elmquist
Journal:  J Clin Invest       Date:  2005-12       Impact factor: 14.808

3.  Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions.

Authors:  Vaishnav Krishnan; Ming-Hu Han; Danielle L Graham; Olivier Berton; William Renthal; Scott J Russo; Quincey Laplant; Ami Graham; Michael Lutter; Diane C Lagace; Subroto Ghose; Robin Reister; Paul Tannous; Thomas A Green; Rachael L Neve; Sumana Chakravarty; Arvind Kumar; Amelia J Eisch; David W Self; Francis S Lee; Carol A Tamminga; Donald C Cooper; Howard K Gershenfeld; Eric J Nestler
Journal:  Cell       Date:  2007-10-19       Impact factor: 41.582

4.  Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite.

Authors:  Alfonso Abizaid; Zhong-Wu Liu; Zane B Andrews; Marya Shanabrough; Erzsebet Borok; John D Elsworth; Robert H Roth; Mark W Sleeman; Marina R Picciotto; Matthias H Tschöp; Xiao-Bing Gao; Tamas L Horvath
Journal:  J Clin Invest       Date:  2006-10-19       Impact factor: 14.808

5.  A role of ghrelin in neuroendocrine and behavioral responses to stress in mice.

Authors:  A Asakawa; A Inui; T Kaga; H Yuzuriha; T Nagata; M Fujimiya; G Katsuura; S Makino; M A Fujino; M Kasuga
Journal:  Neuroendocrinology       Date:  2001-09       Impact factor: 4.914

6.  Orexin signaling mediates the antidepressant-like effect of calorie restriction.

Authors:  Michael Lutter; Vaishnav Krishnan; Scott J Russo; Saendy Jung; Colleen A McClung; Eric J Nestler
Journal:  J Neurosci       Date:  2008-03-19       Impact factor: 6.167

Review 7.  Neuropeptides in eating disorders.

Authors:  David C Jimerson; Barbara E Wolfe
Journal:  CNS Spectr       Date:  2004-07       Impact factor: 3.790

8.  Ghrelin controls hippocampal spine synapse density and memory performance.

Authors:  Sabrina Diano; Susan A Farr; Stephen C Benoit; Ewan C McNay; Ivaldo da Silva; Balazs Horvath; F Spencer Gaskin; Naoko Nonaka; Laura B Jaeger; William A Banks; John E Morley; Shirly Pinto; Robert S Sherwin; Lin Xu; Kelvin A Yamada; Mark W Sleeman; Matthias H Tschöp; Tamas L Horvath
Journal:  Nat Neurosci       Date:  2006-02-19       Impact factor: 24.884

9.  Acute psychological stress raises plasma ghrelin in the rat.

Authors:  Elin Kristenssson; Monika Sundqvist; Maria Astin; Marita Kjerling; Hillevi Mattsson; Charlotta Dornonville de la Cour; Rolf Håkanson; Erik Lindström
Journal:  Regul Pept       Date:  2006-03-06

10.  Hypothalamic orexin neurons regulate arousal according to energy balance in mice.

Authors:  Akihiro Yamanaka; Carsten T Beuckmann; Jon T Willie; Junko Hara; Natsuko Tsujino; Michihiro Mieda; Makoto Tominaga; Ken ichi Yagami; Fumihiro Sugiyama; Katsutoshi Goto; Masashi Yanagisawa; Takeshi Sakurai
Journal:  Neuron       Date:  2003-06-05       Impact factor: 17.173
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  214 in total

Review 1.  Linking molecules to mood: new insight into the biology of depression.

Authors:  Vaishnav Krishnan; Eric J Nestler
Journal:  Am J Psychiatry       Date:  2010-09-15       Impact factor: 18.112

2.  Hypothalamic oxytocin mediates adaptation mechanism against chronic stress in rats.

Authors:  Jun Zheng; Reji Babygirija; Mehmet Bülbül; Diana Cerjak; Kirk Ludwig; Toku Takahashi
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2010-08-05       Impact factor: 4.052

Review 3.  Circadian rhythms and mood regulation: insights from pre-clinical models.

Authors:  Colleen A McClung
Journal:  Eur Neuropsychopharmacol       Date:  2011-08-11       Impact factor: 4.600

4.  Postprandial ghrelin response is reduced in patients with Parkinson's disease and idiopathic REM sleep behaviour disorder: a peripheral biomarker for early Parkinson's disease?

Authors:  Marcus M Unger; Jens C Möller; Katharina Mankel; Karla M Eggert; Katharina Bohne; Maren Bodden; Karin Stiasny-Kolster; Peter H Kann; Geert Mayer; Johannes J Tebbe; Wolfgang H Oertel
Journal:  J Neurol       Date:  2010-12-24       Impact factor: 4.849

Review 5.  Homeostatic and hedonic signals interact in the regulation of food intake.

Authors:  Michael Lutter; Eric J Nestler
Journal:  J Nutr       Date:  2009-01-28       Impact factor: 4.798

Review 6.  Functional biomarkers of depression: diagnosis, treatment, and pathophysiology.

Authors:  Heath D Schmidt; Richard C Shelton; Ronald S Duman
Journal:  Neuropsychopharmacology       Date:  2011-08-03       Impact factor: 7.853

7.  Analysis of brain nuclei accessible to ghrelin present in the cerebrospinal fluid.

Authors:  A Cabral; G Fernandez; M Perello
Journal:  Neuroscience       Date:  2013-09-13       Impact factor: 3.590

8.  Variant BDNF-Val66Met Polymorphism is Associated with Layer-Specific Alterations in GABAergic Innervation of Pyramidal Neurons, Elevated Anxiety and Reduced Vulnerability of Adolescent Male Mice to Activity-Based Anorexia.

Authors:  Yi-Wen Chen; Olivia Surgent; Barkha S Rana; Francis Lee; Chiye Aoki
Journal:  Cereb Cortex       Date:  2017-08-01       Impact factor: 5.357

9.  Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism.

Authors:  Zane B Andrews; Derek Erion; Rudolph Beiler; Zhong-Wu Liu; Alfonso Abizaid; Jeffrey Zigman; John D Elsworth; Joseph M Savitt; Richard DiMarchi; Matthias Tschoep; Robert H Roth; Xiao-Bing Gao; Tamas L Horvath
Journal:  J Neurosci       Date:  2009-11-11       Impact factor: 6.167

Review 10.  Neurobiology of resilience.

Authors:  Scott J Russo; James W Murrough; Ming-Hu Han; Dennis S Charney; Eric J Nestler
Journal:  Nat Neurosci       Date:  2012-10-14       Impact factor: 24.884
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