Michael Jonathan Plaza1, Elizabeth A Morris2, Sunitha B Thakur3. 1. Department of Radiology, Memorial Sloan Kettering Cancer Center, 300 East 66th Street, New York, NY 10065. Electronic address: Michael.j.plaza@gmail.com. 2. Department of Radiology, Memorial Sloan Kettering Cancer Center, 300 East 66th Street, New York, NY 10065. Electronic address: morrise@mskcc.org. 3. Department of Radiology, Memorial Sloan Kettering Cancer Center, 300 East 66th Street, New York, NY 10065. Electronic address: thakurs@mskcc.org.
Abstract
OBJECTIVE: To evaluate effects of fibroglandular tissue (FGT) composition and background parenchymal enhancement (BPE) on diffusion tensor imaging (DTI) parameters in normal breast tissue. METHODS: DTI analysis was performed on 35 breasts with regions of interest drawn to include only normal tissue. Breasts were dichotomized by FGT composition and by BPE; DTI parameters were compared. RESULTS: The λ1 principal diffusion coefficient was lower in breasts with moderate/marked BPE versus those with minimal/mild BPE (P=.039). All other parameters were unaffected. CONCLUSION: λ1 is sensitive to differences in BPE within normal breast tissue that should be taken into account in DTI evaluation.
OBJECTIVE: To evaluate effects of fibroglandular tissue (FGT) composition and background parenchymal enhancement (BPE) on diffusion tensor imaging (DTI) parameters in normal breast tissue. METHODS: DTI analysis was performed on 35 breasts with regions of interest drawn to include only normal tissue. Breasts were dichotomized by FGT composition and by BPE; DTI parameters were compared. RESULTS: The λ1 principal diffusion coefficient was lower in breasts with moderate/marked BPE versus those with minimal/mild BPE (P=.039). All other parameters were unaffected. CONCLUSION: λ1 is sensitive to differences in BPE within normal breast tissue that should be taken into account in DTI evaluation.
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