Literature DB >> 2713165

HIV-1 core proteins expressed from recombinant vaccinia viruses.

G Rautmann1, M P Kieny, R Brandely, K Dott, M Girard, L Montagnier, J P Lecocq.   

Abstract

The sequences encoding the core proteins p55, p25, and p18 of the human immunodeficiency virus (HIV-1) have been inserted into the vaccinia virus genome. Infection of cultured cells with the live recombinant viruses led to the expression of proteins that were recognized by sera from HIV-seropositive individuals. Immunization of mice with the recombinant virus expressing the HIV p25 protein and the p55 precursor yielded high levels of antibodies directed against the corresponding HIV antigens. The data obtained are discussed in terms of the possible use of these live recombinant viruses in the development of a strategy toward an AIDS vaccine.

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Year:  1989        PMID： 2713165     DOI： 10.1089/aid.1989.5.147

Source DB:  PubMed          Journal:  AIDS Res Hum Retroviruses        ISSN： 0889-2229            Impact factor:   2.205


  7 in total

1.  Epstein-Barr virus-specific cytotoxic T cell responses in HIV-1 infection: different kinetics in patients progressing to opportunistic infection or non-Hodgkin's lymphoma.

Authors:  M J Kersten; M R Klein; A M Holwerda; F Miedema; M H van Oers
Journal:  J Clin Invest       Date:  1997-04-01       Impact factor: 14.808

2.  Enhanced presentation of major histocompatibility complex class I-restricted human immunodeficiency virus type 1 (HIV-1) Gag-specific epitopes after DNA immunization with vectors coding for vesicular stomatitis virus glycoprotein-pseudotyped HIV-1 Gag particles.

Authors:  D Marsac; D Loirat; C Petit; O Schwartz; M-L Michel
Journal:  J Virol       Date:  2002-08       Impact factor: 5.103

3.  Carboxyl-terminal and central regions of human immunodeficiency virus-1 NEF recognized by cytotoxic T lymphocytes from lymphoid organs. An in vitro limiting dilution analysis.

Authors:  F Hadida; A Parrot; M P Kieny; B Sadat-Sowti; C Mayaud; P Debre; B Autran
Journal:  J Clin Invest       Date:  1992-01       Impact factor: 14.808

4.  Oligoclonal expansion of HIV-specific cytotoxic CD8 T lymphocytes in the skin of HIV-1-infected patients with cutaneous pseudolymphoma.

Authors:  H Bachelez; F Hadida; C Parizot; B Flageul; M Kemula; L Dubertret; P Debree; G Gorochov
Journal:  J Clin Invest       Date:  1998-06-01       Impact factor: 14.808

5.  Gag-specific cytotoxic T lymphocytes from human immunodeficiency virus type 1-infected individuals: Gag epitopes are clustered in three regions of the p24gag protein.

Authors:  F Buseyne; M McChesney; F Porrot; S Kovarik; B Guy; Y Rivière
Journal:  J Virol       Date:  1993-02       Impact factor: 5.103

6.  Multispecific and heterogeneous recognition of the gag protein by cytotoxic T lymphocytes (CTL) from HIV-infected patients: factors other than the MHC control the epitopic specificities.

Authors:  F Buseyne; G Janvier; B Fleury; D Schmidt; Y Rivière
Journal:  Clin Exp Immunol       Date:  1994-09       Impact factor: 4.330

7.  Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics.

Authors:  M R Klein; C A van Baalen; A M Holwerda; S R Kerkhof Garde; R J Bende; I P Keet; J K Eeftinck-Schattenkerk; A D Osterhaus; H Schuitemaker; F Miedema
Journal:  J Exp Med       Date:  1995-04-01       Impact factor: 14.307
  7 in total

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