Literature DB >> 7521806

Multispecific and heterogeneous recognition of the gag protein by cytotoxic T lymphocytes (CTL) from HIV-infected patients: factors other than the MHC control the epitopic specificities.

F Buseyne1, G Janvier, B Fleury, D Schmidt, Y Rivière.   

Abstract

The HIV gag polyprotein is a major target for recognition by CTL in infected humans. Using recombinant vaccinia viruses (rVV) expressing truncations of the p24gag, and the p18gag, p15gag and HIV-2 p56gag proteins, the characterization of epitope regions recognized by in vitro-stimulated peripheral blood mononuclear cells (PBMC) from 18 infected patients has been studied. The gag-specific response of most individuals is polyclonal and multispecific, and interindividual variations between target epitope regions were frequently observed, despite shared MHC alleles. As CTL may play an important role in the control of HIV replication in infected hosts, these results have important implications for designing vaccine strategies.

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Year:  1994        PMID： 7521806      PMCID： PMC1534855          DOI： 10.1111/j.1365-2249.1994.tb06094.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  53 in total

1.  Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule.

Authors:  S J Powis; E V Deverson; W J Coadwell; A Ciruela; N S Huskisson; H Smith; G W Butcher; J C Howard
Journal:  Nature       Date:  1992-05-21       Impact factor: 49.962

2.  HIV-1 gag-specific cytotoxic T lymphocytes recognize multiple highly conserved epitopes. Fine specificity of the gag-specific response defined by using unstimulated peripheral blood mononuclear cells and cloned effector cells.

Authors:  R P Johnson; A Trocha; L Yang; G P Mazzara; D L Panicali; T M Buchanan; B D Walker
Journal:  J Immunol       Date:  1991-09-01       Impact factor: 5.422

3.  Protection against lethal cytomegalovirus infection by a recombinant vaccine containing a single nonameric T-cell epitope.

Authors:  M Del Val; H J Schlicht; H Volkmer; M Messerle; M J Reddehase; U H Koszinowski
Journal:  J Virol       Date:  1991-07       Impact factor: 5.103

4.  Epitope recognition of conserved HIV envelope sequences by human cytotoxic T lymphocytes.

Authors:  G Dadaglio; A Leroux; P Langlade-Demoyen; E M Bahraoui; F Traincard; R Fisher; F Plata
Journal:  J Immunol       Date:  1991-10-01       Impact factor: 5.422

5.  Multiple subsets of HIV-specific cytotoxic T lymphocytes in humans and in mice.

Authors:  N Chenciner; F Michel; G Dadaglio; P Langlade-Demoyen; A Hoffenbach; A Leroux; F Garcia-Pons; G Rautmann; B Guy; J M Guillon
Journal:  Eur J Immunol       Date:  1989-09       Impact factor: 5.532

6.  An HLA-C-restricted CD8+ cytotoxic T-lymphocyte clone recognizes a highly conserved epitope on human immunodeficiency virus type 1 gag.

Authors:  R A Littaua; M B Oldstone; A Takeda; C Debouck; J T Wong; C U Tuazon; B Moss; F Kievits; F A Ennis
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

7.  In vivo persistence of a HIV-1-encoded HLA-B27-restricted cytotoxic T lymphocyte epitope despite specific in vitro reactivity.

Authors:  A Meyerhans; G Dadaglio; J P Vartanian; P Langlade-Demoyen; R Frank; B Asjö; F Plata; S Wain-Hobson
Journal:  Eur J Immunol       Date:  1991-10       Impact factor: 5.532

8.  Detection of a vigorous HIV-1-specific cytotoxic T lymphocyte response in cerebrospinal fluid from infected persons with AIDS dementia complex.

Authors:  C Jassoy; R P Johnson; B A Navia; J Worth; B D Walker
Journal:  J Immunol       Date:  1992-11-01       Impact factor: 5.422

9.  Recognition of a highly conserved region of human immunodeficiency virus type 1 gp120 by an HLA-Cw4-restricted cytotoxic T-lymphocyte clone.

Authors:  R P Johnson; A Trocha; T M Buchanan; B D Walker
Journal:  J Virol       Date:  1993-01       Impact factor: 5.103

10.  Long-term culture and fine specificity of human cytotoxic T-lymphocyte clones reactive with human immunodeficiency virus type 1.

Authors:  B D Walker; C Flexner; K Birch-Limberger; L Fisher; T J Paradis; A Aldovini; R Young; B Moss; R T Schooley
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205
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  3 in total

1.  Patient-specific cytotoxic T-lymphocyte cross-recognition of naturally occurring variants of a human immunodeficiency virus type 1 (HIV-1) p24gag epitope by HIV-1-infected children.

Authors:  F Buseyne; M L Chaix; C Rouzioux; S Blanche; Y Rivière
Journal:  J Virol       Date:  2001-05       Impact factor: 5.103

2.  Identification of HIV protein-derived cytotoxic T lymphocyte (CTL) epitopes for their possible use as synthetic vaccine.

Authors:  C Brander; W J Pichler; G Corradin
Journal:  Clin Exp Immunol       Date:  1995-07       Impact factor: 4.330

3.  LAMP-1 Chimeric to HIV-1 p55Gag in the Immunization of Neonate Mice Induces an Early Germinal Center Formation and AID Expression.

Authors:  Franciane Mouradian Emidio Teixeira; Luana de Mendonça Oliveira; Anna Julia Pietrobon; Érika Machado de Salles; Maria Regina D'Império Lima; Isabelle Freire Tabosa Viana; Roberto Dias Lins; Paula Ordonhez Rigato; Ernesto Torres de Azevedo Marques; Alberto José da Silva Duarte; Maria Notomi Sato
Journal:  Vaccines (Basel)       Date:  2022-08-03
  3 in total

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