BACKGROUND: Increased breast density is a strong risk factor for breast cancer and also decreases the sensitivity of mammographic screening. The purpose of our study was to compare breast density for black and white women using quantitative measures. METHODS: Breast density was assessed among 5282 black and 4216 white women screened using digital mammography. Breast Imaging-Reporting and Data System (BI-RADS) density was obtained from radiologists' reports. Quantitative measures for dense area, area percent density (PD), dense volume, and volume percent density were estimated using validated, automated software. Breast density was categorized as dense or nondense based on BI-RADS categories or based on values above and below the median for quantitative measures. Logistic regression was used to estimate the odds of having dense breasts by race, adjusted for age, body mass index (BMI), age at menarche, menopause status, family history of breast or ovarian cancer, parity and age at first birth, and current hormone replacement therapy (HRT) use. All statistical tests were two-sided. RESULTS: There was a statistically significant interaction of race and BMI on breast density. After accounting for age, BMI, and breast cancer risk factors, black women had statistically significantly greater odds of high breast density across all quantitative measures (eg, PD nonobese odds ratio [OR] = 1.18, 95% confidence interval [CI] = 1.02 to 1.37, P = .03, PD obese OR = 1.26, 95% CI = 1.04 to 1.53, P = .02). There was no statistically significant difference in BI-RADS density by race. CONCLUSIONS: After accounting for age, BMI, and other risk factors, black women had higher breast density than white women across all quantitative measures previously associated with breast cancer risk. These results may have implications for risk assessment and screening.
BACKGROUND: Increased breast density is a strong risk factor for breast cancer and also decreases the sensitivity of mammographic screening. The purpose of our study was to compare breast density for black and white women using quantitative measures. METHODS: Breast density was assessed among 5282 black and 4216 white women screened using digital mammography. Breast Imaging-Reporting and Data System (BI-RADS) density was obtained from radiologists' reports. Quantitative measures for dense area, area percent density (PD), dense volume, and volume percent density were estimated using validated, automated software. Breast density was categorized as dense or nondense based on BI-RADS categories or based on values above and below the median for quantitative measures. Logistic regression was used to estimate the odds of having dense breasts by race, adjusted for age, body mass index (BMI), age at menarche, menopause status, family history of breast or ovarian cancer, parity and age at first birth, and current hormone replacement therapy (HRT) use. All statistical tests were two-sided. RESULTS: There was a statistically significant interaction of race and BMI on breast density. After accounting for age, BMI, and breast cancer risk factors, black women had statistically significantly greater odds of high breast density across all quantitative measures (eg, PD nonobese odds ratio [OR] = 1.18, 95% confidence interval [CI] = 1.02 to 1.37, P = .03, PD obese OR = 1.26, 95% CI = 1.04 to 1.53, P = .02). There was no statistically significant difference in BI-RADS density by race. CONCLUSIONS: After accounting for age, BMI, and other risk factors, black women had higher breast density than white women across all quantitative measures previously associated with breast cancer risk. These results may have implications for risk assessment and screening.
Authors: Johanna Holm; Keith Humphreys; Jingmei Li; Alexander Ploner; Abbas Cheddad; Mikael Eriksson; Sven Törnberg; Per Hall; Kamila Czene Journal: J Clin Oncol Date: 2015-02-02 Impact factor: 44.544
Authors: Charlotte C Gard; Erin J Aiello Bowles; Diana L Miglioretti; Stephen H Taplin; Carolyn M Rutter Journal: Breast J Date: 2015-07-01 Impact factor: 2.431
Authors: Etta D Pisano; Constantine Gatsonis; Edward Hendrick; Martin Yaffe; Janet K Baum; Suddhasatta Acharyya; Emily F Conant; Laurie L Fajardo; Lawrence Bassett; Carl D'Orsi; Roberta Jong; Murray Rebner Journal: N Engl J Med Date: 2005-09-16 Impact factor: 91.245
Authors: Linda E Kelemen; V Shane Pankratz; Thomas A Sellers; Kathy R Brandt; Alice Wang; Carol Janney; Zachary S Fredericksen; James R Cerhan; Celine M Vachon Journal: Am J Epidemiol Date: 2008-04-02 Impact factor: 4.897
Authors: Jane Ding; Ruth Warren; Iqbal Warsi; Nick Day; Deborah Thompson; Michael Brady; Christopher Tromans; Ralph Highnam; Douglas Easton Journal: Cancer Epidemiol Biomarkers Prev Date: 2008-05 Impact factor: 4.254
Authors: Norman Boyd; Lisa Martin; Anoma Gunasekara; Olga Melnichouk; Gord Maudsley; Chris Peressotti; Martin Yaffe; Salomon Minkin Journal: Cancer Epidemiol Biomarkers Prev Date: 2009-06 Impact factor: 4.254
Authors: Linda Titus-Ernstoff; Anna N A Tosteson; Claudia Kasales; Julia Weiss; Martha Goodrich; Elizabeth E Hatch; Patricia A Carney Journal: Cancer Causes Control Date: 2006-12 Impact factor: 2.506
Authors: Amanda Eng; Zoe Gallant; John Shepherd; Valerie McCormack; Jingmei Li; Mitch Dowsett; Sarah Vinnicombe; Steve Allen; Isabel dos-Santos-Silva Journal: Breast Cancer Res Date: 2014-09-20 Impact factor: 6.466
Authors: Christine Gunn; Ariel Maschke; Timothy Bickmore; Mark Kennedy; Margaret F Hopkins; Michael D C Fishman; Michael K Paasche-Orlow; Erica T Warner Journal: J Gen Intern Med Date: 2020-01-09 Impact factor: 5.128
Authors: Aimilia Gastounioti; Christine Damases Kasi; Christopher G Scott; Kathleen R Brandt; Matthew R Jensen; Carrie B Hruska; Fang F Wu; Aaron D Norman; Emily F Conant; Stacey J Winham; Karla Kerlikowske; Despina Kontos; Celine M Vachon Journal: Radiology Date: 2020-05-12 Impact factor: 11.105
Authors: Karla Kerlikowske; Christopher G Scott; Amir P Mahmoudzadeh; Lin Ma; Stacey Winham; Matthew R Jensen; Fang Fang Wu; Serghei Malkov; V Shane Pankratz; Steven R Cummings; John A Shepherd; Kathleen R Brandt; Diana L Miglioretti; Celine M Vachon Journal: Ann Intern Med Date: 2018-05-01 Impact factor: 25.391
Authors: Karen J Wernli; Erin A Bowles; Sarah Knerr; Kathleen A Leppig; Kelly Ehrlich; Hongyuan Gao; Marc D Schwartz; Suzanne C O'Neill Journal: Perm J Date: 2020-12
Authors: Michael C S Bissell; Karla Kerlikowske; Brian L Sprague; Jeffery A Tice; Charlotte C Gard; Katherine Y Tossas; Garth H Rauscher; Amy Trentham-Dietz; Louise M Henderson; Tracy Onega; Theresa H M Keegan; Diana L Miglioretti Journal: Cancer Epidemiol Biomarkers Prev Date: 2020-07-29 Impact factor: 4.254
Authors: Louise M Henderson; Mary W Marsh; Kathryn Earnhardt; Michael Pritchard; Thad S Benefield; Robert P Agans; Sheila S Lee Journal: Cancer Date: 2020-09-14 Impact factor: 6.860
Authors: Tara M Friebel-Klingner; Sarah Ehsan; Emily F Conant; Despina Kontos; Susan M Domchek; Anne Marie McCarthy Journal: Breast Cancer Res Treat Date: 2021-08-03 Impact factor: 4.872