Elizabeth C Graham1, Yuyi You2, Con Yiannikas3, Raymond Garrick4, John Parratt3, Michael H Barnett5, Alexander Klistorner6. 1. Save Sight Institute, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia. 2. Save Sight Institute, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia 2Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia. 3. Royal North Shore Hospital, Sydney, New South Wales, Australia. 4. St Vincent Hospital, Sydney, New South Wales, Australia. 5. Brain and Mind Research Institute, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia. 6. Save Sight Institute, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia 2Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia 5Brain and Mind Research Institute, Sydney Medical Sch.
Abstract
PURPOSE: To examine the rate of retinal ganglion cell (RGC) layer and retinal nerve fiber layer (RNFL) changes in nonoptic neuritis (NON) eyes of relapsing remitting multiple sclerosis (RRMS) patients, and to find a specific imaging parameter useful for identifying disease progression. METHODS: Forty-five consecutive RRMS patients and 20 age- and sex-matched healthy subjects were enrolled. All patients were followed up for 3 years with annual optical coherence tomography (OCT) scans, which included a peripapillary ring scan protocol for RNFL analysis and a macular radial star-like scan to obtain RGC/inner plexiform layer (IPL) thickness measures. Healthy controls were scanned twice, 3 years apart. RESULTS: Retinal ganglion cell/inner plexiform layer and temporal RNFL (tRNFL) demonstrated highly significant thinning (P < 0.01), but all nasal segments and global RNFL (gRNFL) were not significantly different from normal controls. While receiver operating characteristics (ROC) analysis showed no advantage of RGC/IPL over tRNFL in cross-sectional detection of thinning, cut-off point based of fifth percentile in healthy controls demonstrated higher rate of abnormality for RGC/IPL. There was a significant progressive loss of RGC/IPL and tRNFL during the follow-up period. The largest thickness reduction was observed in tRNFL. ROC analysis demonstrated that tRNFL provided better sensitivity/specificity for detecting change over time than RGC/IPL (area under the curve [AUC] 0.78 vs. 0.52), which was confirmed by higher detection rate when 95th percentile of progression in healthy controls was used as a cut-off. CONCLUSIONS: This study confirmed significant thinning of RGC/IPL and tRNFL in NON eyes of RRMS patients. Progressive losses were more apparent on tRNFL, while RGC/IPL showed less change over the follow-up period.
PURPOSE: To examine the rate of retinal ganglion cell (RGC) layer and retinal nerve fiber layer (RNFL) changes in nonoptic neuritis (NON) eyes of relapsing remitting multiple sclerosis (RRMS) patients, and to find a specific imaging parameter useful for identifying disease progression. METHODS: Forty-five consecutive RRMS patients and 20 age- and sex-matched healthy subjects were enrolled. All patients were followed up for 3 years with annual optical coherence tomography (OCT) scans, which included a peripapillary ring scan protocol for RNFL analysis and a macular radial star-like scan to obtain RGC/inner plexiform layer (IPL) thickness measures. Healthy controls were scanned twice, 3 years apart. RESULTS: Retinal ganglion cell/inner plexiform layer and temporal RNFL (tRNFL) demonstrated highly significant thinning (P < 0.01), but all nasal segments and global RNFL (gRNFL) were not significantly different from normal controls. While receiver operating characteristics (ROC) analysis showed no advantage of RGC/IPL over tRNFL in cross-sectional detection of thinning, cut-off point based of fifth percentile in healthy controls demonstrated higher rate of abnormality for RGC/IPL. There was a significant progressive loss of RGC/IPL and tRNFL during the follow-up period. The largest thickness reduction was observed in tRNFL. ROC analysis demonstrated that tRNFL provided better sensitivity/specificity for detecting change over time than RGC/IPL (area under the curve [AUC] 0.78 vs. 0.52), which was confirmed by higher detection rate when 95th percentile of progression in healthy controls was used as a cut-off. CONCLUSIONS: This study confirmed significant thinning of RGC/IPL and tRNFL in NON eyes of RRMS patients. Progressive losses were more apparent on tRNFL, while RGC/IPL showed less change over the follow-up period.
Authors: Anna M Pietroboni; Tiziana Carandini; Laura Dell'Arti; Francesca Bovis; Annalisa Colombi; Milena A De Riz; Elena Casazza; Elisa Scola; Chiara Fenoglio; Andrea Arighi; Giorgio G Fumagalli; Fabio Triulzi; Daniela Galimberti; Francesco Viola; Elio Scarpini Journal: Neurol Sci Date: 2020-04-30 Impact factor: 3.307
Authors: Yuyi You; Elizabeth C Graham; Ting Shen; Con Yiannikas; John Parratt; Vivek Gupta; Joshua Barton; Michael Dwyer; Michael H Barnett; Clare L Fraser; Stuart L Graham; Alexander Klistorner Journal: Neurol Neuroimmunol Neuroinflamm Date: 2017-12-15
Authors: Ulrika Birkeldh; Ali Manouchehrinia; Max Albert Hietala; Jan Hillert; Tomas Olsson; Fredrik Piehl; Ingrid Skelton Kockum; Lou Brundin; Ori Zahavi; Marika Wahlberg-Ramsay; Rune Brautaset; Maria Nilsson Journal: Front Neurol Date: 2017-12-13 Impact factor: 4.003