Literature DB >> 2712547

Zidovudine antagonizes the action of pyrimethamine in experimental infection with Toxoplasma gondii.

D M Israelski1, C Tom, J S Remington.   

Abstract

The effect of zidovudine (azidothymidine; AZT) on the action of pyrimethamine against Toxoplasma gondii was investigated. Zidovudine was found to antagonize the toxoplasmacidal effect of low concentrations of pyrimethamine in vitro, and in vitro synergism of pyrimethamine and sulfadiazine against T. gondii was reversed by zidovudine. Zidovudine also antagonized the therapeutic effect of pyrimethamine in mice acutely infected with T. gondii.

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Year:  1989        PMID： 2712547      PMCID： PMC171416          DOI： 10.1128/AAC.33.1.30

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Pyrimethamine concentrations in serum and cerebrospinal fluid during treatment of acute Toxoplasma encephalitis in patients with AIDS.

Authors:  L M Weiss; C Harris; M Berger; H B Tanowitz; M Wittner
Journal:  J Infect Dis       Date:  1988-03       Impact factor: 5.226

2.  Treatment of central nervous system toxoplasmosis with pyrimethamine/sulfadiazine combination in 35 patients with the acquired immunodeficiency syndrome. Efficacy of long-term continuous therapy.

Authors:  C Leport; F Raffi; S Matheron; C Katlama; B Regnier; A G Saimot; C Marche; C Vedrenne; J L Vilde
Journal:  Am J Med       Date:  1988-01       Impact factor: 4.965

Review 3.  AIDS commentary. Azidothymidine.

Authors:  M S Hirsch
Journal:  J Infect Dis       Date:  1988-03       Impact factor: 5.226

4.  New micromethod to study the effect of antimicrobial agents on Toxoplasma gondii: comparison of sulfadoxine and sulfadiazine individually and in combination with pyrimethamine and study of clindamycin, metronidazole, and cyclosporin A.

Authors:  D G Mack; R McLeod
Journal:  Antimicrob Agents Chemother       Date:  1984-07       Impact factor: 5.191

5.  Broad spectrum antiretroviral activity of 2',3'-dideoxynucleosides.

Authors:  J E Dahlberg; H Mitsuya; S B Blam; S Broder; S A Aaronson
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205

6.  Central-nervous-system toxoplasmosis in homosexual men and parenteral drug abusers.

Authors:  B Wong; J W Gold; A E Brown; M Lange; R Fried; M Grieco; D Mildvan; J Giron; M L Tapper; C W Lerner
Journal:  Ann Intern Med       Date:  1984-01       Impact factor: 25.391

7.  Suppression of mouse viraemia and retroviral disease by 3'-azido-3'-deoxythymidine.

Authors:  R M Ruprecht; L G O'Brien; L D Rossoni; S Nusinoff-Lehrman
Journal:  Nature       Date:  1986 Oct 2-8       Impact factor: 49.962

8.  Potent effect of trimetrexate, a lipid-soluble antifolate, on Toxoplasma gondii.

Authors:  J A Kovacs; C J Allegra; B A Chabner; J C Swan; J Drake; M Lunde; J E Parrillo; H Masur
Journal:  J Infect Dis       Date:  1987-05       Impact factor: 5.226

9.  Cerebral toxoplasmosis complicating the acquired immune deficiency syndrome: clinical and neuropathological findings in 27 patients.

Authors:  B A Navia; C K Petito; J W Gold; E S Cho; B D Jordan; R W Price
Journal:  Ann Neurol       Date:  1986-03       Impact factor: 10.422

10.  Potent in vitro and in vivo antitoxoplasma activity of the lipid-soluble antifolate trimetrexate.

Authors:  C J Allegra; J A Kovacs; J C Drake; J C Swan; B A Chabner; H Masur
Journal:  J Clin Invest       Date:  1987-02       Impact factor: 14.808
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  8 in total

1.  Anti-toxoplasma activities of antiretroviral drugs and interactions with pyrimethamine and sulfadiazine in vitro.

Authors:  F Derouin; M Santillana-Hayat
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

Review 2.  Adverse effects and drug interactions of medications commonly used in the treatment of adult HIV positive patients.

Authors:  R Heylen; R Miller
Journal:  Genitourin Med       Date:  1996-08

3.  Activity of gamma interferon in combination with pyrimethamine or clindamycin in treatment of murine toxoplasmosis.

Authors:  D Israelski; J Remington
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1990-05       Impact factor: 3.267

4.  Effects of 2',3'-dideoxyinosine on Toxoplasma gondii cysts in mice.

Authors:  M E Sarciron; P Lawton; C Saccharin; A F Petavy; F Peyron
Journal:  Antimicrob Agents Chemother       Date:  1997-07       Impact factor: 5.191

5.  Efficacy of pyrimethamine/sulfadoxine in the prevention of toxoplasmic encephalitis relapses and Pneumocystis carinii pneumonia in HIV-infected patients.

Authors:  B Ruf; D Schürmann; F Bergmann; W Schüler-Maué; T Grünewald; H J Gottschalk; H Witt; H D Pohle
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1993-05       Impact factor: 3.267

6.  Treatment of acute experimental toxoplasmosis with investigational poloxamers.

Authors:  J L Krahenbuhl; Y Fukutomi; L Gu
Journal:  Antimicrob Agents Chemother       Date:  1993-11       Impact factor: 5.191

7.  Evaluation of risk and diagnostic value of quantitative assays for anti-Toxoplasma gondii immunoglobulin A (IgA), IgE, and IgM and analytical study of specific IgG in immunodeficient patients.

Authors:  J M Pinon; F Foudrinier; G Mougeot; C Marx; D Aubert; O Toupance; G Niel; M Danis; P Camerlynck; G Remy
Journal:  J Clin Microbiol       Date:  1995-04       Impact factor: 5.948

8.  Activities of antifolate, antiviral, and other drugs in an immunosuppressed rat model of Pneumocystis carinii pneumonia.

Authors:  P D Walzer; J Foy; P Steele; C K Kim; M White; R S Klein; B A Otter; C Allegra
Journal:  Antimicrob Agents Chemother       Date:  1992-09       Impact factor: 5.191
  8 in total

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