Literature DB >> 27125241

The Effect of Depressive Symptoms on Adherence to Daily Oral PrEP in Men who have Sex with Men and Transgender Women: A Marginal Structural Model Analysis of The iPrEx OLE Study.

Megha L Mehrotra1,2, David V Glidden3, Vanessa McMahan4, K Rivet Amico5, Sybil Hosek6, Patricia Defechereux4, Kenneth H Mayer7, Valdilea G Veloso8, Linda-Gail Bekker9, Vivian I Avelino-Silva10, Mauro Schechter11, Robert M Grant4,3.   

Abstract

We assessed the role of depressive symptoms on adherence to daily oral FTC/TDF for HIV PrEP in cisgender men who have sex with men (MSM) and transgender women who have sex with men (TGW) using data from the iPrEx OLE study. A marginal structural logistic regression model was used to estimate the effect of time-varying CES-D scores on having protective levels of drug concentration, adjusting for confounding by sexual practices over time, prior adherence, and baseline demographic characteristics. We found a non-monotonic relationship between CES-D score and odds of protective FTC/TDF levels in MSM. We found evidence that the effect of depression on adherence varied between MSM and TGW, and that depressive symptoms did not contribute greatly to decreased adherence on a population scale. We recommend that depressive symptoms not preclude the prescription of PrEP, and that MSM and TGW be studied separately.

Entities:  

Keywords:  Adherence; Depression; HIV prevention; Marginal structural model; Men who have sex with men; PrEP; Preexposure prophylaxis; Transgender women; iPrEx OLE

Mesh：

Substances：

Year:  2016        PMID： 27125241      PMCID： PMC4912836          DOI： 10.1007/s10461-016-1415-9

Source DB:  PubMed          Journal:  AIDS Behav        ISSN： 1090-7165


  33 in total

1.  Uptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: a cohort study.

Authors:  Robert M Grant; Peter L Anderson; Vanessa McMahan; Albert Liu; K Rivet Amico; Megha Mehrotra; Sybil Hosek; Carlos Mosquera; Martin Casapia; Orlando Montoya; Susan Buchbinder; Valdilea G Veloso; Kenneth Mayer; Suwat Chariyalertsak; Linda-Gail Bekker; Esper G Kallas; Mauro Schechter; Juan Guanira; Lane Bushman; David N Burns; James F Rooney; David V Glidden
Journal:  Lancet Infect Dis       Date:  2014-07-22       Impact factor: 25.071

2.  The relationship between depression, anxiety and medication adherence among patients receiving antiretroviral treatment in South Africa.

Authors:  Adriaan Nel; Ashraf Kagee
Journal:  AIDS Care       Date:  2012-12-11

3.  Emtricitabine-tenofovir concentrations and pre-exposure prophylaxis efficacy in men who have sex with men.

Authors:  Peter L Anderson; David V Glidden; Albert Liu; Susan Buchbinder; Javier R Lama; Juan Vicente Guanira; Vanessa McMahan; Lane R Bushman; Martín Casapía; Orlando Montoya-Herrera; Valdilea G Veloso; Kenneth H Mayer; Suwat Chariyalertsak; Mauro Schechter; Linda-Gail Bekker; Esper Georges Kallás; Robert M Grant
Journal:  Sci Transl Med       Date:  2012-09-12       Impact factor: 17.956

4.  Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana.

Authors:  Michael C Thigpen; Poloko M Kebaabetswe; Lynn A Paxton; Dawn K Smith; Charles E Rose; Tebogo M Segolodi; Faith L Henderson; Sonal R Pathak; Fatma A Soud; Kata L Chillag; Rodreck Mutanhaurwa; Lovemore Ian Chirwa; Michael Kasonde; Daniel Abebe; Evans Buliva; Roman J Gvetadze; Sandra Johnson; Thom Sukalac; Vasavi T Thomas; Clyde Hart; Jeffrey A Johnson; C Kevin Malotte; Craig W Hendrix; John T Brooks
Journal:  N Engl J Med       Date:  2012-07-11       Impact factor: 91.245

5.  Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.

Authors:  Jared M Baeten; Deborah Donnell; Patrick Ndase; Nelly R Mugo; James D Campbell; Jonathan Wangisi; Jordan W Tappero; Elizabeth A Bukusi; Craig R Cohen; Elly Katabira; Allan Ronald; Elioda Tumwesigye; Edwin Were; Kenneth H Fife; James Kiarie; Carey Farquhar; Grace John-Stewart; Aloysious Kakia; Josephine Odoyo; Akasiima Mucunguzi; Edith Nakku-Joloba; Rogers Twesigye; Kenneth Ngure; Cosmas Apaka; Harrison Tamooh; Fridah Gabona; Andrew Mujugira; Dana Panteleeff; Katherine K Thomas; Lara Kidoguchi; Meighan Krows; Jennifer Revall; Susan Morrison; Harald Haugen; Mira Emmanuel-Ogier; Lisa Ondrejcek; Robert W Coombs; Lisa Frenkel; Craig Hendrix; Namandjé N Bumpus; David Bangsberg; Jessica E Haberer; Wendy S Stevens; Jairam R Lingappa; Connie Celum
Journal:  N Engl J Med       Date:  2012-07-11       Impact factor: 91.245

6.  Prevalence of mental disorders, psychological distress, and mental health services use among lesbian, gay, and bisexual adults in the United States.

Authors:  Susan D Cochran; Vickie M Mays; J Greer Sullivan
Journal:  J Consult Clin Psychol       Date:  2003-02

7.  Risk factors for HIV infection among men who have sex with men.

Authors:  Beryl A Koblin; Marla J Husnik; Grant Colfax; Yijian Huang; Maria Madison; Kenneth Mayer; Patrick J Barresi; Thomas J Coates; Margaret A Chesney; Susan Buchbinder
Journal:  AIDS       Date:  2006-03-21       Impact factor: 4.177

8.  Functional impairment and health care utilization among HIV-infected men who have sex with men: the relationship with depression and post-traumatic stress.

Authors:  Conall O'Cleirigh; Margie Skeer; Kenneth H Mayer; Steven A Safren
Journal:  J Behav Med       Date:  2009-06-13

9.  Preexposure prophylaxis for HIV infection among African women.

Authors:  Lut Van Damme; Amy Corneli; Khatija Ahmed; Kawango Agot; Johan Lombaard; Saidi Kapiga; Mookho Malahleha; Fredrick Owino; Rachel Manongi; Jacob Onyango; Lucky Temu; Modie Constance Monedi; Paul Mak'Oketch; Mankalimeng Makanda; Ilse Reblin; Shumani Elsie Makatu; Lisa Saylor; Haddie Kiernan; Stella Kirkendale; Christina Wong; Robert Grant; Angela Kashuba; Kavita Nanda; Justin Mandala; Katrien Fransen; Jennifer Deese; Tania Crucitti; Timothy D Mastro; Douglas Taylor
Journal:  N Engl J Med       Date:  2012-07-11       Impact factor: 91.245

Review 10.  An Overview of Depression among Transgender Women.

Authors:  Beth Hoffman
Journal:  Depress Res Treat       Date:  2014-03-13
View more
  18 in total

1.  Syndemics and the PrEP Cascade: Results from a Sample of Young Latino Men Who Have Sex with Men.

Authors:  Aaron J Blashill; John P Brady; Benjamin M Rooney; Carlos E Rodriguez-Diaz; Keith J Horvath; Jill Blumenthal; Sheldon Morris; David J Moore; Steven A Safren
Journal:  Arch Sex Behav       Date:  2019-10-07

2.  HIV PrEP services for MSM in China: a mixed-methods study.

Authors:  Chunqing Lin; Li Li; Jun Liu; Xiaobing Fu; Jun Chen; Wei Cao; Yan Li
Journal:  AIDS Care       Date:  2021-03-02

3.  Community Legal Systems: Targeting PrEP and HIV Education to Decrease Risk of HIV Transmission.

Authors:  Leanne Whiteside-Mansell; LaTunja Sockwell; Daniel Knight; Cynthia Crone
Journal:  AIDS Behav       Date:  2021-03-19

Review 4.  Pre-exposure prophylaxis for HIV prevention in women: current perspectives.

Authors:  Charlene A Flash; Sannisha K Dale; Douglas S Krakower
Journal:  Int J Womens Health       Date:  2017-05-31

5.  Skating on thin ice: stimulant use and sub-optimal adherence to HIV pre-exposure prophylaxis.

Authors:  J Carlo Hojilla; David Vlahov; David V Glidden; K Rivet Amico; Megha Mehrotra; Robert Hance; Robert M Grant; Adam W Carrico
Journal:  J Int AIDS Soc       Date:  2018-03       Impact factor: 5.396

6.  Effect of Depression on Adherence to Oral PrEP Among Men and Women in East Africa.

Authors:  Jennifer Velloza; Jared M Baeten; Jessica Haberer; Kenneth Ngure; Elizabeth Irungu; Nelly R Mugo; Connie Celum; Renee Heffron
Journal:  J Acquir Immune Defic Syndr       Date:  2018-11-01       Impact factor: 3.731

7.  Mental Health, Social Influences, and HIV Pre-exposure Prophylaxis (PrEP) Utilization Among Men and Transgender Individuals Screening for HIV Prevention Trials.

Authors:  Sarah M Wood; Knashawn H Morales; David Metzger; Annet Davis; Danielle Fiore; Danielle Petsis; Kezia Barnett; Helen C Koenig; Nadia Dowshen; Robert Gross; Ian Frank
Journal:  AIDS Behav       Date:  2021-02

Review 8.  Intervening for HIV prevention and mental health: a review of global literature.

Authors:  Pamela Y Collins; Jennifer Velloza; Tessa Concepcion; Linda Oseso; Lydia Chwastiak; Christopher G Kemp; Jane Simoni; Bradley H Wagenaar
Journal:  J Int AIDS Soc       Date:  2021-06       Impact factor: 5.396

9.  Profiles of Depressive Symptoms Among Men Who Have Sex With Men and Transgender Women During the COVID-19 Outbreak in Mexico: A Latent Class Analysis.

Authors:  Diego Cerecero-Garcia; Heleen Vermandere; Ietza Bojorquez; José Gómez-Castro; José Arturo Sánchez-Ochoa; Araczy Martínez-Dávalos; Ivonne Huerta-Icelo; Sergio Bautista-Arredondo
Journal:  Front Public Health       Date:  2021-06-07

10.  The Effect of Depression on Adherence to HIV Pre-exposure Prophylaxis Among High-Risk South African Women in HPTN 067/ADAPT.

Authors:  Jennifer Velloza; Renee Heffron; K Rivet Amico; Ali Rowhani-Rahbar; James P Hughes; Maoji Li; Bonnie J Dye; Connie Celum; Linda-Gail Bekker; Robert M Grant
Journal:  AIDS Behav       Date:  2020-07
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.