| Literature DB >> 27122600 |
Giuseppe Patti1, Vittorio Pengo2, Rossella Marcucci3, Plinio Cirillo4, Giulia Renda5, Francesca Santilli6, Paolo Calabrò7, Alberto Ranieri De Caterina5,8, Ilaria Cavallari1, Elisabetta Ricottini1, Vito Maurizio Parato9,10, Giacomo Zoppellaro2, Giuseppe Di Gioia1, Pietro Sedati1, Vincenzo Cicchitti9, Giovanni Davì6, Enrica Golia7, Ivana Pariggiano7, Paola Simeone6, Rosanna Abbate3, Domenico Prisco3, Marco Zimarino5, Francesco Sofi3,11, Felicita Andreotti12, Raffaele De Caterina.
Abstract
The left atrial appendage (LAA) is the main source of thromboembolism in patients with non-valvular atrial fibrillation (AF). As such, the LAA can be the target of specific occluding device therapies. Optimal management of patients with AF includes a comprehensive knowledge of the many aspects related to LAA structure and thrombosis. Here we provide baseline notions on the anatomy and function of the LAA, and then focus on current imaging tools for the identification of anatomical varieties. We also describe pathogenetic mechanisms of LAA thrombosis in AF patients, and examine the available evidence on treatment strategies for LAA thrombosis, including the use of non-vitamin K antagonist oral anticoagulants and interventional approaches. Published on behalf of the European Society of Cardiology. All rights reserved.Entities:
Keywords: Anticoagulants; Atrial fibrillation; Left atrial appendage; NOACs; Non-vitamin K antagonist oral anticoagulants; Occlusion devices; Stroke; Systemic embolism; Thromboembolism
Mesh：
Year: 2017 PMID： 27122600 DOI： 10.1093/eurheartj/ehw159
Source DB: PubMed Journal: Eur Heart J ISSN： 0195-668X Impact factor: 29.983