Susanne Rautiainen1, Pamela M Rist2, Robert J Glynn3, Julie E Buring2, J Michael Gaziano4, Howard D Sesso5. 1. Divisions of Preventive Medicine and Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; susanne.rautiainen@ki.se. 2. Divisions of Preventive Medicine and Department of Epidemiology, and. 3. Divisions of Preventive Medicine and Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA; and. 4. Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA; VA Boston Healthcare System, Boston, MA. 5. Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA; Department of Epidemiology, and.
Abstract
BACKGROUND: Although multivitamins are widely used by US adults, few prospective studies have investigated their association with the long- and short-term risks of cardiovascular disease (CVD). OBJECTIVE: The aim of this study was to investigate how multivitamin use is associated with the risk of CVD in initially healthy men at baseline. METHODS: We studied 18,530 male physicians aged ≥40 y from the Physicians' Health StudyI cohort who were free of CVD and cancer at baseline (1982). All men provided a wide range of self-reported lifestyle and clinical factors plus intake of selected foods and dietary supplements. Cox proportional hazards models were used to calculate multivariable-adjusted HRs (95% CIs). RESULTS: During a mean follow-up of 12.2 y (total of 225,287 person-years), there were 1697 incident cases of major CVD (defined as nonfatal myocardial infarction, nonfatal stroke, and CVD death). In multivariable-adjusted analyses, no significant associations were observed among baseline multivitamin users compared with nonusers for the risk of major CVD events (HR: 0.94; 95% CI: 0.84, 1.05), whereas a self-reported duration of ≥20 y at baseline was associated with lower risk (HR: 0.56; 95% CI: 0.35, 0.90; P-trend = 0.05). Baseline multivitamin use was also significantly inversely associated with the risk of cardiac revascularization (HR: 0.86; 95% CI: 0.75, 0.98). Baseline use of multivitamins was not significantly associated with other CVD endpoints. CONCLUSION: In this long-term prospective study in initially healthy men, multivitamin use for ≥20 y was associated with a lower risk of major CVD events.
RCT Entities:
BACKGROUND: Although multivitamins are widely used by US adults, few prospective studies have investigated their association with the long- and short-term risks of cardiovascular disease (CVD). OBJECTIVE: The aim of this study was to investigate how multivitamin use is associated with the risk of CVD in initially healthy men at baseline. METHODS: We studied 18,530 male physicians aged ≥40 y from the Physicians' Health Study I cohort who were free of CVD and cancer at baseline (1982). All men provided a wide range of self-reported lifestyle and clinical factors plus intake of selected foods and dietary supplements. Cox proportional hazards models were used to calculate multivariable-adjusted HRs (95% CIs). RESULTS: During a mean follow-up of 12.2 y (total of 225,287 person-years), there were 1697 incident cases of major CVD (defined as nonfatal myocardial infarction, nonfatal stroke, and CVD death). In multivariable-adjusted analyses, no significant associations were observed among baseline multivitamin users compared with nonusers for the risk of major CVD events (HR: 0.94; 95% CI: 0.84, 1.05), whereas a self-reported duration of ≥20 y at baseline was associated with lower risk (HR: 0.56; 95% CI: 0.35, 0.90; P-trend = 0.05). Baseline multivitamin use was also significantly inversely associated with the risk of cardiac revascularization (HR: 0.86; 95% CI: 0.75, 0.98). Baseline use of multivitamins was not significantly associated with other CVD endpoints. CONCLUSION: In this long-term prospective study in initially healthy men, multivitamin use for ≥20 y was associated with a lower risk of major CVD events.
Authors: Regan L Bailey; Jaime J Gahche; Cindy V Lentino; Johanna T Dwyer; Jody S Engel; Paul R Thomas; Joseph M Betz; Christopher T Sempos; Mary Frances Picciano Journal: J Nutr Date: 2010-12-22 Impact factor: 4.798
Authors: Marian L Neuhouser; Sylvia Wassertheil-Smoller; Cynthia Thomson; Aaron Aragaki; Garnet L Anderson; JoAnn E Manson; Ruth E Patterson; Thomas E Rohan; Linda van Horn; James M Shikany; Asha Thomas; Andrea LaCroix; Ross L Prentice Journal: Arch Intern Med Date: 2009-02-09
Authors: Howard D Sesso; William G Christen; Vadim Bubes; Joanne P Smith; Jean MacFadyen; Miriam Schvartz; JoAnn E Manson; Robert J Glynn; Julie E Buring; J Michael Gaziano Journal: JAMA Date: 2012-11-07 Impact factor: 56.272
Authors: Susanne Rautiainen; J Michael Gaziano; William G Christen; Vadim Bubes; Gregory Kotler; Robert J Glynn; JoAnn E Manson; Julie E Buring; Howard D Sesso Journal: JAMA Cardiol Date: 2017-06-01 Impact factor: 14.676
Authors: Pamela M Rist; Howard D Sesso; Lisa G Johnson; Aaron K Aragaki; Lu Wang; Susanne Rautiainen; Aditi Hazra; Deirdre K Tobias; Meryl S LeBoff; Hagen Schroeter; Georgina Friedenberg; Trisha Copeland; Allison Clar; Lesley F Tinker; Rebecca P Hunt; Shari S Bassuk; Ara Sarkissian; Douglas C Smith; Eduardo Pereira; William R Carrick; Emily S Wion; Jennifer Schoenberg; Garnet L Anderson; JoAnn E Manson Journal: Contemp Clin Trials Date: 2022-03-12 Impact factor: 2.261
Authors: Regan L Bailey; Tieraona Low Dog; Abbie E Smith-Ryan; Sai Krupa Das; Fiona C Baker; Zeynep Madak-Erdogan; Billy R Hammond; Howard D Sesso; Alex Eapen; Susan H Mitmesser; Andrea Wong; Haiuyen Nguyen Journal: J Nutr Date: 2022-07-06 Impact factor: 4.687
Authors: Howard D Sesso; Pamela M Rist; Aaron K Aragaki; Susanne Rautiainen; Lisa G Johnson; Georgina Friedenberg; Trisha Copeland; Allison Clar; Samia Mora; M Vinayaga Moorthy; Ara Sarkissian; Jean Wactawski-Wende; Lesley F Tinker; William R Carrick; Garnet L Anderson; JoAnn E Manson Journal: Am J Clin Nutr Date: 2022-06-07 Impact factor: 8.472
Authors: Xiaoyue Xu; Zumin Shi; Gang Liu; Dennis Chang; Sally C Inglis; John J Hall; Aletta E Schutte; Julie E Byles; Deborah Parker Journal: Nutrients Date: 2021-03-15 Impact factor: 5.717