Akiko Furuya1, Shigeru Suzuki2, Miho Oshima3, Satoshi Amamiya3, Atsushi Nakao4, Mariko Araki5, Kayo Mizutani6, Satoshi Hayano7, Katsumi Ushijima8, Aya Imamoto9, Nobuhiko Nagano10, Tatsuhiko Urakami11, Kumihiro Matsuo1, Yusuke Tanahashi1, Hiroshi Azuma1, Masafumi Koga12. 1. Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan. 2. Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan. shige5p@asahikawa-med.ac.jp. 3. Department of Pediatrics, Sapporo Tokushukai Hospital, Sapporo, Japan. 4. Department of Neonatology, Japanese Red Cross Medical Center, Tokyo, Japan. 5. Department of Pediatrics, Kochi Medical School, Kochi, Japan. 6. Department of Neonatology, Kameda Medical Center, Kamogawa, Japan. 7. Department of Pediatrics, Anjo Kosei Hospital, Anjo, Japan. 8. Department of Pediatrics, Yokkaichi Municipal Hospital, Yokkaichi, Japan. 9. Department of Pediatrics and Perinatology, Tottori University Faculty of Medicine, Tottori, Japan. 10. Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan. 11. Department of Pediatrics, Surugadai Nihon University Hospital, Tokyo, Japan. 12. Department of Internal Medicine, Kawanishi City Hospital, Kawanishi, Japan.
Abstract
BACKGROUND: We previously showed that glycated albumin (GA) is a useful glycemic control indicator in patients with neonatal diabetes mellitus (NDM), and that age-adjusted GA (Aa-GA) can reflect more accurately glycemic control status. Here, we investigated whether the age at diagnosis influences Aa-GA at diagnosis of NDM. METHODS: Eight patients with NDM whose GA was measured at diagnosis (age at diagnosis: 39 ± 18 days; GA: 31.3 ± 7.6%; Aa-GA: 47.1 ± 10.3%; plasma glucose: 525 ± 194 mg/dl) were included. Aa-GA was calculated as follows: Aa-GA = GA × 14.0/[1.77 × log-age (days) + 6.65]. Correlations of GA or Aa-GA at diagnosis with its logarithmically transformed age in days (log-age), plasma glucose, and their product were investigated. RESULTS: GA at diagnosis was not significantly correlated with log-age or plasma glucose. On the other hand, Aa-GA at diagnosis was significantly positively correlated with plasma glucose (R = 0.75, P = 0.031) and was more strongly positively correlated with the product of plasma glucose and log-age (R = 0.82, P = 0.012) although it was not correlated with log-age. CONCLUSION: Aa-GA at diagnosis is influenced by both age in days and plasma glucose. This finding is likely to show the aspect that age in days is almost equal to diabetes duration because glycemic control indicators including GA reflect the weighted mean of plasma glucose.
BACKGROUND: We previously showed that glycated albumin (GA) is a useful glycemic control indicator in patients with neonatal diabetes mellitus (NDM), and that age-adjusted GA (Aa-GA) can reflect more accurately glycemic control status. Here, we investigated whether the age at diagnosis influences Aa-GA at diagnosis of NDM. METHODS: Eight patients with NDM whose GA was measured at diagnosis (age at diagnosis: 39 ± 18 days; GA: 31.3 ± 7.6%; Aa-GA: 47.1 ± 10.3%; plasma glucose: 525 ± 194 mg/dl) were included. Aa-GA was calculated as follows: Aa-GA = GA × 14.0/[1.77 × log-age (days) + 6.65]. Correlations of GA or Aa-GA at diagnosis with its logarithmically transformed age in days (log-age), plasma glucose, and their product were investigated. RESULTS: GA at diagnosis was not significantly correlated with log-age or plasma glucose. On the other hand, Aa-GA at diagnosis was significantly positively correlated with plasma glucose (R = 0.75, P = 0.031) and was more strongly positively correlated with the product of plasma glucose and log-age (R = 0.82, P = 0.012) although it was not correlated with log-age. CONCLUSION: Aa-GA at diagnosis is influenced by both age in days and plasma glucose. This finding is likely to show the aspect that age in days is almost equal to diabetes duration because glycemic control indicators including GA reflect the weighted mean of plasma glucose.
Authors: Anna L Gloyn; Ewan R Pearson; Jennifer F Antcliff; Peter Proks; G Jan Bruining; Annabelle S Slingerland; Neville Howard; Shubha Srinivasan; José M C L Silva; Janne Molnes; Emma L Edghill; Timothy M Frayling; I Karen Temple; Deborah Mackay; Julian P H Shield; Zdenek Sumnik; Adrian van Rhijn; Jerry K H Wales; Penelope Clark; Shaun Gorman; Javier Aisenberg; Sian Ellard; Pål R Njølstad; Frances M Ashcroft; Andrew T Hattersley Journal: N Engl J Med Date: 2004-04-29 Impact factor: 91.245