Shigeru Suzuki1, Akiko Furuya2, Miho Oshima3, Satoshi Amamiya4, Atsushi Nakao5, Keiko Wada6, Koji Okuhara7, Satoshi Hayano8, Aya Imamoto9, Kumihiro Matsuo2, Yusuke Tanahashi2, Hiroshi Azuma2, Masafumi Koga10. 1. Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan shige5p@asahikawa-med.ac.jp. 2. Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan. 3. Department of Pediatrics, Sapporo Tokushukai Hospital, Sapporo, Japan. 4. Department of Pediatrics, Sapporo Tokushukai Hospital, Sapporo, Japan Amamiya Shounika Clinic, Sapporo, Japan. 5. Department of Neonatology, Japanese Red Cross Medical Center, Tokyo, Japan. 6. Department of Neonatology, Hyogo Prefectural Kobe Children's Hospital Perinatal Center, Kobe, Japan. 7. Department of Pediatrics, Tenshi Hospital, Sapporo, Japan. 8. Department of Pediatrics, Anjo Kosei Hospital, Anjo, Japan Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan. 9. Department of Pediatrics and Perinatology, Tottori University Faculty of Medicine, Yonago, Japan. 10. Department of Internal Medicine, Kawanishi City Hospital, Kawanishi, Japan.
Abstract
BACKGROUND: Glycated albumin is a useful glycaemic control indicator for neonatal diabetes mellitus. However, glycated albumin concentrations in infants are lower than those in adults and increase in an age-dependent manner. Based on our investigation of non-diabetic subjects, we proposed the possibility that the reference range for adults may be used regardless of age, provided that age-adjusted glycated albumin is employed. In the present study, we evaluate the usefulness of age-adjusted glycated albumin in neonatal diabetes mellitus patients. METHODS: Six neonatal diabetes mellitus patients (four patients with permanent neonatal diabetes mellitus and two patients with transient neonatal diabetes mellitus) were included. Measured glycated albumin or age-adjusted glycated albumin was compared to calculated glycated albumin, which was determined using calculation formulae we had reported based on past blood glucose over the 50 days before measurement of glycated albumin. RESULTS: Measured glycated albumin was significantly lower than calculated glycated albumin (20.5 ± 4.9% versus 28.2 ± 6.1%; p < 0.0001), whereas age-adjusted glycated albumin was equivalent to calculated glycated albumin, showing no significant difference (27.5 ± 6.8% versus 28.2 ± 6.1%). Measured glycated albumin concentrations in patients with transient neonatal diabetes mellitus in remission were lower than the reference range for adults, whereas age-adjusted glycated albumin concentrations were within the reference range for adults. CONCLUSION: We demonstrated that age-adjusted glycated albumin concentrations were consistent with calculated glycated albumin. Age-adjusted glycated albumin is therefore a useful glycaemic control indicator for neonatal diabetes mellitus patients.
BACKGROUND: Glycated albumin is a useful glycaemic control indicator for neonatal diabetes mellitus. However, glycated albumin concentrations in infants are lower than those in adults and increase in an age-dependent manner. Based on our investigation of non-diabetic subjects, we proposed the possibility that the reference range for adults may be used regardless of age, provided that age-adjusted glycated albumin is employed. In the present study, we evaluate the usefulness of age-adjusted glycated albumin in neonatal diabetes mellituspatients. METHODS: Six neonatal diabetes mellituspatients (four patients with permanent neonatal diabetes mellitus and two patients with transient neonatal diabetes mellitus) were included. Measured glycated albumin or age-adjusted glycated albumin was compared to calculated glycated albumin, which was determined using calculation formulae we had reported based on past blood glucose over the 50 days before measurement of glycated albumin. RESULTS: Measured glycated albumin was significantly lower than calculated glycated albumin (20.5 ± 4.9% versus 28.2 ± 6.1%; p < 0.0001), whereas age-adjusted glycated albumin was equivalent to calculated glycated albumin, showing no significant difference (27.5 ± 6.8% versus 28.2 ± 6.1%). Measured glycated albumin concentrations in patients with transient neonatal diabetes mellitus in remission were lower than the reference range for adults, whereas age-adjusted glycated albumin concentrations were within the reference range for adults. CONCLUSION: We demonstrated that age-adjusted glycated albumin concentrations were consistent with calculated glycated albumin. Age-adjusted glycated albumin is therefore a useful glycaemic control indicator for neonatal diabetes mellituspatients.