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Literature DB >> 27119625

Treatment of an alopecia areata patient with tofacitinib results in regrowth of hair and changes in serum and skin biomarkers.

Ali Jabbari¹, Nhan Nguyen¹, Jane E Cerise¹, Grace Ulerio¹, Annemieke de Jong¹, Raphael Clynes¹, Angela M Christiano¹, Julian Mackay-Wiggan¹.

Abstract

Entities: Chemical Disease Gene Species

Keywords: JAK inhibitors; alopecia areata; biomarkers; tofacitinib

Mesh：

Substances：

Year: 2016 PMID： 27119625 PMCID： PMC4963264 DOI： 10.1111/exd.13060

Source DB: PubMed Journal: Exp Dermatol ISSN： 0906-6705 Impact factor: 3.960

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5 in total

1. Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.

Authors: Luzhou Xing; Zhenpeng Dai; Ali Jabbari; Jane E Cerise; Claire A Higgins; Weijuan Gong; Annemieke de Jong; Sivan Harel; Gina M DeStefano; Lisa Rothman; Pallavi Singh; Lynn Petukhova; Julian Mackay-Wiggan; Angela M Christiano; Raphael Clynes
Journal: Nat Med Date: 2014-08-17 Impact factor: 53.440

2. Killing two birds with one stone: oral tofacitinib reverses alopecia universalis in a patient with plaque psoriasis.

Authors: Brittany G Craiglow; Brett A King
Journal: J Invest Dermatol Date: 2014-06-18 Impact factor: 8.551

Review 3. Genetic basis of alopecia areata: a roadmap for translational research.

Authors: Ali Jabbari; Lynn Petukhova; Rita M Cabral; Raphael Clynes; Angela M Christiano
Journal: Dermatol Clin Date: 2012-10-23 Impact factor: 3.478

4. Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.

Authors: Regina C Betz; Lynn Petukhova; Stephan Ripke; Hailiang Huang; Androniki Menelaou; Silke Redler; Tim Becker; Stefanie Heilmann; Tarek Yamany; Madeliene Duvic; Maria Hordinsky; David Norris; Vera H Price; Julian Mackay-Wiggan; Annemieke de Jong; Gina M DeStefano; Susanne Moebus; Markus Böhm; Ulrike Blume-Peytavi; Hans Wolff; Gerhard Lutz; Roland Kruse; Li Bian; Christopher I Amos; Annette Lee; Peter K Gregersen; Bettina Blaumeiser; David Altshuler; Raphael Clynes; Paul I W de Bakker; Markus M Nöthen; Mark J Daly; Angela M Christiano
Journal: Nat Commun Date: 2015-01-22 Impact factor: 14.919

5. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib.

Authors: Ali Jabbari; Zhenpeng Dai; Luzhou Xing; Jane E Cerise; Yuval Ramot; Yackov Berkun; Gina A Montealegre Sanchez; Raphaela Goldbach-Mansky; Angela M Christiano; Raphael Clynes; Abraham Zlotogorski
Journal: EBioMedicine Date: 2015-02-26 Impact factor: 8.143

5 in total

15 in total

1. Integrative analysis of rare copy number variants and gene expression data in alopecia areata implicates an aetiological role for autophagy.

Authors: Lynn Petukhova; Aakash V Patel; Rachel K Rigo; Li Bian; Miguel Verbitsky; Simone Sanna-Cherchi; Stephanie O Erjavec; Alexa R Abdelaziz; Jane E Cerise; Ali Jabbari; Angela M Christiano
Journal: Exp Dermatol Date: 2019-07-09 Impact factor: 3.960

10. An excellent response to tofacitinib in a Brazilian adolescent patient with alopecia areata: A case report and a review of the literature.

Authors: Rachel Berbert Ferreira; Sineida Berbert Ferreira; Morton Aaron Scheinberg
Journal: Clin Case Rep Date: 2019-11-21

Treatment of an alopecia areata patient with tofacitinib results in regrowth of hair and changes in serum and skin biomarkers.

1. Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.

2. Killing two birds with one stone: oral tofacitinib reverses alopecia universalis in a patient with plaque psoriasis.

Review 3. Genetic basis of alopecia areata: a roadmap for translational research.

4. Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.

5. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib.

1. Integrative analysis of rare copy number variants and gene expression data in alopecia areata implicates an aetiological role for autophagy.

2. Treatment of Alopecia Areata With Tofacitinib.

3. Successful hair regrowth in a Korean patient with alopecia universalis following tofacitinib treatment.

Review 4. T-cell positioning by chemokines in autoimmune skin diseases.

5. CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata.

Review 6. JAK inhibitors in dermatology: The promise of a new drug class.

Review 7. Alopecia Areata: An Update on Treatment Options for Children.

8. High-throughput T cell receptor sequencing identifies clonally expanded CD8+ T cell populations in alopecia areata.

Review 9. An Imperative Need for Further Genetic Studies of Alopecia Areata.

10. An excellent response to tofacitinib in a Brazilian adolescent patient with alopecia areata: A case report and a review of the literature.