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Literature DB >> 27117331

Fibroblasts form a hospitable metastatic niche in the liver.

Abstract

The liver is the most common metastatic route of pancreatic cancer. Early recruitment of granulin-secreting inflammatory monocytes to the liver is now shown to reprogram hepatic stellate cells into myofibroblasts that modulate the liver microenvironment to support the growth of metastasizing tumour cells.

Entities: Disease Gene

Mesh：

Year: 2016 PMID： 27117331 DOI： 10.1038/ncb3352

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

15 in total

1. Cancer: Fibroblasts for all seasons.

Authors: Erwin F Wagner
Journal: Nature Date: 2016-02-04 Impact factor: 49.962

2. Cancer: Angiogenic awakening.

Authors: Neta Erez
Journal: Nature Date: 2013-07-24 Impact factor: 49.962

3. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival.

Authors: Berna C Özdemir; Tsvetelina Pentcheva-Hoang; Julienne L Carstens; Xiaofeng Zheng; Chia-Chin Wu; Tyler R Simpson; Hanane Laklai; Hikaru Sugimoto; Christoph Kahlert; Sergey V Novitskiy; Ana De Jesus-Acosta; Padmanee Sharma; Pedram Heidari; Umar Mahmood; Lynda Chin; Harold L Moses; Valerie M Weaver; Anirban Maitra; James P Allison; Valerie S LeBleu; Raghu Kalluri
Journal: Cancer Cell Date: 2014-05-22 Impact factor: 31.743

4. Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice.

Authors: Moshe Elkabets; Ann M Gifford; Christina Scheel; Bjorn Nilsson; Ferenc Reinhardt; Mark-Anthony Bray; Anne E Carpenter; Karin Jirström; Kristina Magnusson; Benjamin L Ebert; Fredrik Pontén; Robert A Weinberg; Sandra S McAllister
Journal: J Clin Invest Date: 2011-01-25 Impact factor: 14.808

Review 5. From sentinel cells to inflammatory culprits: cancer-associated fibroblasts in tumour-related inflammation.

Authors: Charlotte Servais; Neta Erez
Journal: J Pathol Date: 2012-11-20 Impact factor: 7.996

6. Interactions between cancer stem cells and their niche govern metastatic colonization.

Authors: Ilaria Malanchi; Albert Santamaria-Martínez; Evelyn Susanto; Hong Peng; Hans-Anton Lehr; Jean-Francois Delaloye; Joerg Huelsken
Journal: Nature Date: 2011-12-07 Impact factor: 49.962

7. LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis.

Authors: Thomas R Cox; Demelza Bird; Ann-Marie Baker; Holly E Barker; Melisa W-Y Ho; Georgina Lang; Janine T Erler
Journal: Cancer Res Date: 2013-01-23 Impact factor: 12.701

8. Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis.

Authors: Sebastian R Nielsen; Valeria Quaranta; Andrea Linford; Perpetua Emeagi; Carolyn Rainer; Almudena Santos; Lucy Ireland; Takao Sakai; Keiko Sakai; Yong-Sam Kim; Dannielle Engle; Fiona Campbell; Daniel Palmer; Jeong Heon Ko; David A Tuveson; Emilio Hirsch; Ainhoa Mielgo; Michael C Schmid
Journal: Nat Cell Biol Date: 2016-04-18 Impact factor: 28.824

Review 9. Fibroblast heterogeneity in the cancer wound.

Authors: Daniel Öhlund; Ela Elyada; David Tuveson
Journal: J Exp Med Date: 2014-07-28 Impact factor: 14.307

Review 10. Genetics and biology of pancreatic ductal adenocarcinoma.

Authors: Haoqiang Ying; Prasenjit Dey; Wantong Yao; Alec C Kimmelman; Giulio F Draetta; Anirban Maitra; Ronald A DePinho
Journal: Genes Dev Date: 2016-02-15 Impact factor: 11.361

2 in total

1. A Plasma-Derived Protein-Metabolite Multiplexed Panel for Early-Stage Pancreatic Cancer.

Authors: Johannes F Fahrmann; Leonidas E Bantis; Michela Capello; Ghislaine Scelo; Jennifer B Dennison; Nikul Patel; Eunice Murage; Jody Vykoukal; Deepali L Kundnani; Lenka Foretova; Eleonora Fabianova; Ivana Holcatova; Vladimir Janout; Ziding Feng; Michele Yip-Schneider; Jianjun Zhang; Randall Brand; Ayumu Taguchi; Anirban Maitra; Paul Brennan; C Max Schmidt; Samir Hanash
Journal: J Natl Cancer Inst Date: 2019-04-01 Impact factor: 13.506

Review 2. The hepatic pre-metastatic niche in pancreatic ductal adenocarcinoma.

Authors: Demi S Houg; Maarten F Bijlsma
Journal: Mol Cancer Date: 2018-06-14 Impact factor: 27.401

2 in total