Literature DB >> 27117330

Orchestrating Wnt signalling for metabolic liver zonation.

Walter Birchmeier1.   

Abstract

Wnt/β-catenin signalling is an important regulator of liver development, zonation and regeneration. The cell surface complex RSPO-LGR4/5-ZNF3/RNF43 is now shown to direct Wnt/β-catenin signalling in orchestrating the division of the liver into functionally distinct metabolic zones, providing insights into the mechanisms that influence organ development and regeneration.

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Year:  2016        PMID： 27117330     DOI： 10.1038/ncb3349

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  15 in total

1.  Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer.

Authors:  Joan Font-Burgada; Shabnam Shalapour; Suvasini Ramaswamy; Brian Hsueh; David Rossell; Atsushi Umemura; Koji Taniguchi; Hayato Nakagawa; Mark A Valasek; Li Ye; Janel L Kopp; Maike Sander; Hannah Carter; Karl Deisseroth; Inder M Verma; Michael Karin
Journal:  Cell       Date:  2015-08-13       Impact factor: 41.582

Review 2.  Transcriptional control in the mammalian liver: liver development, perinatal repression, and zonal gene regulation.

Authors:  B T Spear; L Jin; S Ramasamy; A Dobierzewska
Journal:  Cell Mol Life Sci       Date:  2006-12       Impact factor: 9.261

Review 3.  Organogenesis and development of the liver.

Authors:  Karim Si-Tayeb; Frédéric P Lemaigre; Stephen A Duncan
Journal:  Dev Cell       Date:  2010-02-16       Impact factor: 12.270

4.  Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.

Authors:  Wim de Lau; Nick Barker; Teck Y Low; Bon-Kyoung Koo; Vivian S W Li; Hans Teunissen; Pekka Kujala; Andrea Haegebarth; Peter J Peters; Marc van de Wetering; Daniel E Stange; Johan E van Es; Daniele Guardavaccaro; Richard B M Schasfoort; Yasuaki Mohri; Katsuhiko Nishimori; Shabaz Mohammed; Albert J R Heck; Hans Clevers
Journal:  Nature       Date:  2011-07-04       Impact factor: 49.962

5.  Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.

Authors:  Bon-Kyoung Koo; Maureen Spit; Ingrid Jordens; Teck Y Low; Daniel E Stange; Marc van de Wetering; Johan H van Es; Shabaz Mohammed; Albert J R Heck; Madelon M Maurice; Hans Clevers
Journal:  Nature       Date:  2012-08-30       Impact factor: 49.962

6.  Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice.

Authors:  Shigeki Sekine; Billy Yu-Ang Lan; Melanie Bedolli; Sandy Feng; Matthias Hebrok
Journal:  Hepatology       Date:  2006-04       Impact factor: 17.425

7.  The WNT/β-catenin pathway is a transcriptional regulator of CYP2E1, CYP1A2, and aryl hydrocarbon receptor gene expression in primary human hepatocytes.

Authors:  Sabine Gerbal-Chaloin; Anne-Sophie Dumé; Philippe Briolotti; Sylvie Klieber; Edith Raulet; Cédric Duret; Jean-Michel Fabre; Jeanne Ramos; Patrick Maurel; Martine Daujat-Chavanieu
Journal:  Mol Pharmacol       Date:  2014-09-16       Impact factor: 4.436

8.  ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.

Authors:  Huai-Xiang Hao; Yang Xie; Yue Zhang; Olga Charlat; Emma Oster; Monika Avello; Hong Lei; Craig Mickanin; Dong Liu; Heinz Ruffner; Xiaohong Mao; Qicheng Ma; Raffaella Zamponi; Tewis Bouwmeester; Peter M Finan; Marc W Kirschner; Jeffery A Porter; Fabrizio C Serluca; Feng Cong
Journal:  Nature       Date:  2012-04-29       Impact factor: 49.962

9.  The Wnt/beta-catenin pathway: master regulator of liver zonation?

Authors:  Zoë D Burke; David Tosh
Journal:  Bioessays       Date:  2006-11       Impact factor: 4.345

10.  The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.

Authors:  Lara Planas-Paz; Vanessa Orsini; Luke Boulter; Diego Calabrese; Monika Pikiolek; Florian Nigsch; Yang Xie; Guglielmo Roma; Adriana Donovan; Patricia Marti; Nicolau Beckmann; Michael T Dill; Walter Carbone; Sebastian Bergling; Andrea Isken; Matthias Mueller; Bernd Kinzel; Yi Yang; Xiaohong Mao; Thomas B Nicholson; Raffaella Zamponi; Paola Capodieci; Reginald Valdez; Daniel Rivera; Andreas Loew; Chinweike Ukomadu; Luigi M Terracciano; Tewis Bouwmeester; Feng Cong; Markus H Heim; Stuart J Forbes; Heinz Ruffner; Jan S Tchorz
Journal:  Nat Cell Biol       Date:  2016-04-18       Impact factor: 28.824
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  16 in total

Review 1.  CBP/Catenin antagonists: Targeting LSCs' Achilles heel.

Authors:  Yong-Mi Kim; Eun-Ji Gang; Michael Kahn
Journal:  Exp Hematol       Date:  2017-05-04       Impact factor: 3.084

2.  Clinical implications of WNT/β-catenin signaling for hepatocellular carcinoma.

Authors:  Yoshinari Asaoka; Atsushi Tanaka
Journal:  Glob Health Med       Date:  2020-10-31

Review 3.  Pre-clinical and clinical investigations of metabolic zonation in liver diseases: The potential of microphysiology systems.

Authors:  Alejandro Soto-Gutierrez; Albert Gough; Lawrence A Vernetti; D L Taylor; Satdarshan P Monga
Journal:  Exp Biol Med (Maywood)       Date:  2017-05-03

Review 4.  Principles and functions of metabolic compartmentalization.

Authors:  Liron Bar-Peled; Nora Kory
Journal:  Nat Metab       Date:  2022-10-20

5.  Optogenetic Control of the Canonical Wnt Signaling Pathway During Xenopus laevis Embryonic Development.

Authors:  Vishnu V Krishnamurthy; Hyojeong Hwang; Jia Fu; Jing Yang; Kai Zhang
Journal:  J Mol Biol       Date:  2021-05-19       Impact factor: 6.151

Review 6.  Wnt target genes and where to find them.

Authors:  Aravinda-Bharathi Ramakrishnan; Ken M Cadigan
Journal:  F1000Res       Date:  2017-05-24

7.  Identification and characterization of long noncoding RNAs and mRNAs expression profiles related to postnatal liver maturation of breeder roosters using Ribo-zero RNA sequencing.

Authors:  Shengru Wu; Yanli Liu; Wei Guo; Xi Cheng; Xiaochun Ren; Si Chen; Xueyuan Li; Yongle Duan; Qingzhu Sun; Xiaojun Yang
Journal:  BMC Genomics       Date:  2018-06-27       Impact factor: 3.969

Review 8.  Regenerating the liver: not so simple after all?

Authors:  Malcolm R Alison; Wey-Ran Lin
Journal:  F1000Res       Date:  2016-07-26

9.  Molecular signatures of liver dysfunction are distinct in fungal and bacterial infections in mice.

Authors:  Barbara Schaarschmidt; Sebastian Vlaic; Anna Medyukhina; Sophie Neugebauer; Sandor Nietzsche; Falk A Gonnert; Jürgen Rödel; Mervyn Singer; Michael Kiehntopf; Marc Thilo Figge; Ilse D Jacobsen; Michael Bauer; Adrian T Press
Journal:  Theranostics       Date:  2018-06-13       Impact factor: 11.556

10.  Holistic characterization of single-hepatocyte transcriptome responses to high-fat diet.

Authors:  Sung Rye Park; Chun-Seok Cho; Jingyue Xi; Hyun Min Kang; Jun Hee Lee
Journal:  Am J Physiol Endocrinol Metab       Date:  2020-10-26       Impact factor: 4.310
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