Literature DB >> 17041892

The Wnt/beta-catenin pathway: master regulator of liver zonation?

Zoë D Burke1, David Tosh.   

Abstract

The liver contains two systems for the removal of ammonia - the urea cycle and the enzyme glutamine synthetase. These systems are expressed in a complementary fashion in two distinct populations of hepatocytes, referred to as periportal and perivenous cells. One of the unresolved problems in hepatology has been to elucidate the molecular mechanisms responsible for induction and maintenance of the cellular heterogeneity for ammonia detoxification. There is now a potential molecular explanation for the zonation of the urea cycle and glutamine synthetase based on the Wnt/beta-catenin pathway. (c) 2006 Wiley Periodicals, Inc.

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Year:  2006        PMID： 17041892     DOI： 10.1002/bies.20485

Source DB:  PubMed          Journal:  Bioessays        ISSN： 0265-9247            Impact factor:   4.345


  22 in total

1.  Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems.

Authors:  Felipe T Lee-Montiel; Subin M George; Albert H Gough; Anup D Sharma; Juanfang Wu; Richard DeBiasio; Lawrence A Vernetti; D Lansing Taylor
Journal:  Exp Biol Med (Maywood)       Date:  2017-04-14

2.  Wnt/beta-catenin signaling in hepatic organogenesis.

Authors:  Kari Nejak-Bowen; Satdarshan Ps Monga
Journal:  Organogenesis       Date:  2008-04       Impact factor: 2.500

Review 3.  Liver zonation: Novel aspects of its regulation and its impact on homeostasis.

Authors:  Rolf Gebhardt; Madlen Matz-Soja
Journal:  World J Gastroenterol       Date:  2014-07-14       Impact factor: 5.742

4.  Orchestrating Wnt signalling for metabolic liver zonation.

Authors:  Walter Birchmeier
Journal:  Nat Cell Biol       Date:  2016-04-27       Impact factor: 28.824

5.  Calpain induces N-terminal truncation of β-catenin in normal murine liver development: diagnostic implications in hepatoblastomas.

Authors:  Abigale Lade; Sarangarajan Ranganathan; Jianhua Luo; Satdarshan P S Monga
Journal:  J Biol Chem       Date:  2012-05-21       Impact factor: 5.157

Review 6.  Beta-catenin signaling in hepatic development and progenitors: which way does the WNT blow?

Authors:  Abigale G Lade; Satdarshan P S Monga
Journal:  Dev Dyn       Date:  2010-12-23       Impact factor: 3.780

Review 7.  Wnt signaling in liver cancer.

Authors:  Yutaka Takigawa; Anthony M C Brown
Journal:  Curr Drug Targets       Date:  2008-11       Impact factor: 3.465

Review 8.  Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Authors:  Patricio Godoy; Nicola J Hewitt; Ute Albrecht; Melvin E Andersen; Nariman Ansari; Sudin Bhattacharya; Johannes Georg Bode; Jennifer Bolleyn; Christoph Borner; Jan Böttger; Albert Braeuning; Robert A Budinsky; Britta Burkhardt; Neil R Cameron; Giovanni Camussi; Chong-Su Cho; Yun-Jaie Choi; J Craig Rowlands; Uta Dahmen; Georg Damm; Olaf Dirsch; María Teresa Donato; Jian Dong; Steven Dooley; Dirk Drasdo; Rowena Eakins; Karine Sá Ferreira; Valentina Fonsato; Joanna Fraczek; Rolf Gebhardt; Andrew Gibson; Matthias Glanemann; Chris E P Goldring; María José Gómez-Lechón; Geny M M Groothuis; Lena Gustavsson; Christelle Guyot; David Hallifax; Seddik Hammad; Adam Hayward; Dieter Häussinger; Claus Hellerbrand; Philip Hewitt; Stefan Hoehme; Hermann-Georg Holzhütter; J Brian Houston; Jens Hrach; Kiyomi Ito; Hartmut Jaeschke; Verena Keitel; Jens M Kelm; B Kevin Park; Claus Kordes; Gerd A Kullak-Ublick; Edward L LeCluyse; Peng Lu; Jennifer Luebke-Wheeler; Anna Lutz; Daniel J Maltman; Madlen Matz-Soja; Patrick McMullen; Irmgard Merfort; Simon Messner; Christoph Meyer; Jessica Mwinyi; Dean J Naisbitt; Andreas K Nussler; Peter Olinga; Francesco Pampaloni; Jingbo Pi; Linda Pluta; Stefan A Przyborski; Anup Ramachandran; Vera Rogiers; Cliff Rowe; Celine Schelcher; Kathrin Schmich; Michael Schwarz; Bijay Singh; Ernst H K Stelzer; Bruno Stieger; Regina Stöber; Yuichi Sugiyama; Ciro Tetta; Wolfgang E Thasler; Tamara Vanhaecke; Mathieu Vinken; Thomas S Weiss; Agata Widera; Courtney G Woods; Jinghai James Xu; Kathy M Yarborough; Jan G Hengstler
Journal:  Arch Toxicol       Date:  2013-08-23       Impact factor: 5.153

Review 9.  Spatial heterogeneity in the mammalian liver.

Authors:  Shani Ben-Moshe; Shalev Itzkovitz
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2019-07       Impact factor: 46.802

10.  Modeling Wnt/β-Catenin Target Gene Expression in APC and Wnt Gradients Under Wild Type and Mutant Conditions.

Authors:  Uwe Benary; Bente Kofahl; Andreas Hecht; Jana Wolf
Journal:  Front Physiol       Date:  2013-02-25       Impact factor: 4.566
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