Guo-Xiang Fu1, Min Ji1, Li-Zhi Han1, Chan-Chan Xu1, Feng-Feng Pan1, Ting-Jun Hu1, Yuan Zhong2. 1. Department of Gerontology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600, Yi Shan Road, 200233, Shanghai, People's Republic of China. 2. Department of Gerontology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600, Yi Shan Road, 200233, Shanghai, People's Republic of China. zhongyuan60@126.com.
Abstract
OBJECTIVE: This study was carried out to determine whether changes in hemorheological parameters parallel the severity of essential hypertension. METHODS: A total of 198 older hypertensive patients were recruited and classified into 3 stages of hypertension according to the grading standard of hypertension. The whole blood viscosity (WBV) at various shear rates, plasma viscosity and erythrocyte rheology (including erythrocyte rigidity index, erythrocyte aggregation index and erythrocyte deformation index) were examined. RESULTS: Erythrocyte rheology paralleled the severity of essential hypertension and was significantly correlated to the average 24 h systolic blood pressure and diastolic blood pressure. Logistic analysis revealed that erythrocyte rigidity and the erythrocyte aggregation index were positively correlated with the severity of hypertension, while the erythrocyte deformation index was negatively correlated. No association was found between WBV, plasma viscosity and the severity of hypertension. CONCLUSION: The rheological properties of erythrocyte viscosity were correlated with the severity of hypertension in older people but the WBV and plasma viscosity were not.
OBJECTIVE: This study was carried out to determine whether changes in hemorheological parameters parallel the severity of essential hypertension. METHODS: A total of 198 older hypertensivepatients were recruited and classified into 3 stages of hypertension according to the grading standard of hypertension. The whole blood viscosity (WBV) at various shear rates, plasma viscosity and erythrocyte rheology (including erythrocyte rigidity index, erythrocyte aggregation index and erythrocyte deformation index) were examined. RESULTS: Erythrocyte rheology paralleled the severity of essential hypertension and was significantly correlated to the average 24 h systolic blood pressure and diastolic blood pressure. Logistic analysis revealed that erythrocyte rigidity and the erythrocyte aggregation index were positively correlated with the severity of hypertension, while the erythrocyte deformation index was negatively correlated. No association was found between WBV, plasma viscosity and the severity of hypertension. CONCLUSION: The rheological properties of erythrocyte viscosity were correlated with the severity of hypertension in older people but the WBV and plasma viscosity were not.
Authors: A Luquita; L Urli; M J Svetaz; A M Gennaro; M E Giorgetti; G Pistone; R Volpintesta; S Palatnik; M Rasia Journal: J Biomed Sci Date: 2010-02-12 Impact factor: 8.410
Authors: Beatriz Y Salazar Vázquez; Miguel A Salazar Vázquez; Marcos Intaglietta; Ulf de Faire; Bengt Fagrell; Pedro Cabrales Journal: Vasc Health Risk Manag Date: 2009-06-07
Authors: Aleksandr Y Shamanaev; Oleg I Aliev; Anna M Anishchenko; Anastasia V Sidehmenova; Mark B Plotnikov Journal: Indian J Pharmacol Date: 2017 Jul-Aug Impact factor: 1.200