Literature DB >> 27113081

LXR Regulation of Brain Cholesterol: From Development to Disease.

Rebecca Courtney1, Gary E Landreth2.   

Abstract

Liver X receptors (LXRs) are master regulators of cholesterol homeostasis and inflammation in the central nervous system (CNS). The brain, which contains a disproportionately large amount of the body's total cholesterol (∼25%), requires a complex and delicately balanced cholesterol metabolism to maintain neuronal function. Dysregulation of cholesterol metabolism has been implicated in numerous neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD). Due to their cholesterol-sensing and anti-inflammatory activities, LXRs are positioned centrally in the everyday maintenance of CNS function. This review focuses on recent research into the role of LXRs in the CNS during normal development and homeostasis and in disease states.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  brain; cholesterol; lipoprotein; liver X receptor; neurodegenerative disease

Mesh：

Substances：

Year:  2016        PMID： 27113081      PMCID： PMC4986614          DOI： 10.1016/j.tem.2016.03.018

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  82 in total

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8.  Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake.

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