Literature DB >> 28258087

The role of APOE on lipid homeostasis and inflammation in normal brains.

G William Rebeck1.   

Abstract

The role of APOE in the risk of Alzheimer's disease (AD) has largely focused on its effects on AD pathological processes. However, there are increasing data that APOE genotype affects processes in normal brains. Studies of young cognitively normal humans show effects of APOE genotype on brain structure and activity. Studies of normal APOE knock-in mice show effects of APOE genotype on brain structure, neuronal markers, and behavior. APOE interactions with molecules important for lipid efflux and lipid endocytosis underlie effects of APOE genotype on neuroinflammation and lipoprotein composition. These effects provide important targets for new therapies for reduction of the risk of AD before any signs of pathogenesis.
Copyright © 2017 by the American Society for Biochemistry and Molecular Biology, Inc.

Entities:  

Keywords:  ATP binding cassette transporter A1; Alzheimer’s disease; apolipoprotein E; apolipoproteins; inflammation; lipids/efflux

Mesh：

Substances：

Year:  2017        PMID： 28258087      PMCID： PMC5538293          DOI： 10.1194/jlr.R075408

Source DB:  PubMed          Journal:  J Lipid Res        ISSN： 0022-2275            Impact factor:   5.922


  114 in total

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