Eun Jeong Gong1, Do Hoon Kim2, Hoonsub So1, Ji Yong Ahn1, Kee Wook Jung1, Jeong Hoon Lee1, Kee Don Choi1, Ho June Song1, Gin Hyug Lee1, Hwoon-Yong Jung1, Jin-Ho Kim1. 1. Department of Gastroenterology, Asan Digestive Disease Research Institute, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea. 2. Department of Gastroenterology, Asan Digestive Disease Research Institute, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea. dohoon.md@gmail.com.
Abstract
BACKGROUND AND AIMS: Endoscopic submucosal dissection (ESD) for adenocarcinoma in the esophagogastric junction (EGJ) is a technically difficult procedure. We analyzed the long-term clinical outcomes of ESD for adenocarcinoma in the EGJ to determine the feasibility of this treatment approach. METHODS: Subjects who underwent ESD for Siewert type II adenocarcinoma between December 2004 and December 2011 were eligible for this study. Clinical features and treatment outcomes were retrospectively reviewed using medical records. RESULTS: A total of 88 subjects underwent ESD at our institute. The median patient age was 66 years (interquartile range [IQR] 59-71 years), and the male-to-female ratio was 10.0:1. The median tumor diameter was 20 mm (IQR 14-25 mm), and the median procedure time was 40 min (IQR 30-60 min). Adverse events occurred in nine patients (10.2 %), namely bleeding (n = 6) and suspicious microperforation (n = 3). En bloc, complete, and curative resection rates were 88.6 % (78/88), 83.0 % (73/88), and 60.2 % (53/88), respectively. In multivariate analysis, undifferentiated histology (P = 0.009) and elevated lesions (P = 0.011) were factors associated with noncurative resection. During a median follow-up period of 68.5 months, local tumor recurrence was detected in two patients (2.4 %), and the 5-year overall and disease-specific survival rates were 96.6 and 100.0 %, respectively. CONCLUSIONS: ESD for the treatment of EGJ cancer may be an effective and safe treatment strategy based on favorable long-term outcomes.
BACKGROUND AND AIMS: Endoscopic submucosal dissection (ESD) for adenocarcinoma in the esophagogastric junction (EGJ) is a technically difficult procedure. We analyzed the long-term clinical outcomes of ESD for adenocarcinoma in the EGJ to determine the feasibility of this treatment approach. METHODS: Subjects who underwent ESD for Siewert type II adenocarcinoma between December 2004 and December 2011 were eligible for this study. Clinical features and treatment outcomes were retrospectively reviewed using medical records. RESULTS: A total of 88 subjects underwent ESD at our institute. The median patient age was 66 years (interquartile range [IQR] 59-71 years), and the male-to-female ratio was 10.0:1. The median tumor diameter was 20 mm (IQR 14-25 mm), and the median procedure time was 40 min (IQR 30-60 min). Adverse events occurred in nine patients (10.2 %), namely bleeding (n = 6) and suspicious microperforation (n = 3). En bloc, complete, and curative resection rates were 88.6 % (78/88), 83.0 % (73/88), and 60.2 % (53/88), respectively. In multivariate analysis, undifferentiated histology (P = 0.009) and elevated lesions (P = 0.011) were factors associated with noncurative resection. During a median follow-up period of 68.5 months, local tumor recurrence was detected in two patients (2.4 %), and the 5-year overall and disease-specific survival rates were 96.6 and 100.0 %, respectively. CONCLUSIONS: ESD for the treatment of EGJ cancer may be an effective and safe treatment strategy based on favorable long-term outcomes.
Authors: Y Seto; S Shimoyama; J Kitayama; K Mafune; M Kaminishi; T Aikou; K Arai; K Ohta; A Nashimoto; I Honda; H Yamagishi; Y Yamamura Journal: Gastric Cancer Date: 2001 Impact factor: 7.370