Masayoshi Yamada1, Ichiro Oda, Satoru Nonaka, Haruhisha Suzuki, Shigetaka Yoshinaga, Hirokazu Taniguchi, Shigeki Sekine, Ryoji Kushima, Yutaka Saito, Takuji Gotoda.
Abstract
BACKGROUND AND STUDY AIM: Endoscopic resection has been favored for the management of intramucosal adenocarcinoma of the esophagogastric junction (AEGJ) over standard treatment with surgical resection. Several previous studies have reported only short-term outcomes. The aim of the present study was to report the long-term follow-up and outcomes of endoscopic submucosal dissection (ESD), a representative endoscopic resection method, for the management of superficial AEGJ. PATIENTS AND METHODS: A retrospective cohort study included 53 consecutive patients with superficial AEGJ who underwent ESD between 2001 and 2007 at the National Cancer Center Hospital, Tokyo, Japan. Rates of overall survival, recurrence-free survival, and cause-specific survival of patients with AEGJ after endoscopic resection were analyzed.
RESULTS: The 5-year overall, recurrence-free, and cause-specific survival rates in the 53 patients were 94.2%, 92.3% and 96.1%, respectively. The median follow-up was 6.1 years. En bloc, R0, and curative resection rates were 100 %, 79 %, 68 %, respectively. In 36 patients with curative resection, the cause-specific survival rate was 100 % and no recurrence or metastases were detected. In 17 patients with non-curative resection, recurrence was found in three patients (17 %); two of the three patients died of their disease whilst one patient received chemotherapy.
CONCLUSIONS: Superficial AEGJ can be well controlled by ESD when curative resection is achieved. © Georg Thieme Verlag KG Stuttgart · New York.
BACKGROUND AND STUDY AIM: Endoscopic resection has been favored for the management of intramucosal adenocarcinoma of the esophagogastric junction (AEGJ) over standard treatment with surgical resection. Several previous studies have reported only short-term outcomes. The aim of the present study was to report the long-term follow-up and outcomes of endoscopic submucosal dissection (ESD), a representative endoscopic resection method, for the management of superficial AEGJ. PATIENTS AND METHODS: A retrospective cohort study included 53 consecutive patients with superficial AEGJ who underwent ESD between 2001 and 2007 at the National Cancer Center Hospital, Tokyo, Japan. Rates of overall survival, recurrence-free survival, and cause-specific survival of patients with AEGJ after endoscopic resection were analyzed.
RESULTS: The 5-year overall, recurrence-free, and cause-specific survival rates in the 53 patients were 94.2%, 92.3% and 96.1%, respectively. The median follow-up was 6.1 years. En bloc, R0, and curative resection rates were 100 %, 79 %, 68 %, respectively. In 36 patients with curative resection, the cause-specific survival rate was 100 % and no recurrence or metastases were detected. In 17 patients with non-curative resection, recurrence was found in three patients (17 %); two of the three patients died of their disease whilst one patient received chemotherapy.
CONCLUSIONS: Superficial AEGJ can be well controlled by ESD when curative resection is achieved. © Georg Thieme Verlag KG Stuttgart · New York.
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Mesh：
Year: 2013
PMID： 24288219 DOI： 10.1055/s-0033-1344862
Source DB: PubMed Journal: Endoscopy ISSN： 0013-726X Impact factor: 10.093