Literature DB >> 27111524

Older age may offset genetic influence on affect: The COMT polymorphism and affective well-being across the life span.

Bulent Turan1, Tamara Sims2, Sasha E Best3, Laura L Carstensen2.   

Abstract

The catechol-O-methyltransferase (COMT_Val158Met) genetic polymorphism has been linked to variation in affective well-being. Compared with Val carriers, Met carriers experience lower affective well-being. In parallel, research on aging and affective experience finds that younger adults experience poorer affective well-being than older adults. This study examined how COMT and age may interact to shape daily affective experience across the life span. Results suggest that Met (vs. Val) carriers experience lower levels of affective well-being in younger but not in older ages. These findings suggest that age-related improvements in emotional functioning may offset genetic vulnerabilities to negative affective experience. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

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Year:  2016        PMID： 27111524      PMCID： PMC4850911          DOI： 10.1037/pag0000085

Source DB:  PubMed          Journal:  Psychol Aging        ISSN： 0882-7974


  40 in total

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Authors:  L L Carstensen; M Pasupathi; U Mayr; J R Nesselroade
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4.  Warriors versus worriers: the role of COMT gene variants.

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5.  Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia.

Authors:  M F Egan; T E Goldberg; B S Kolachana; J H Callicott; C M Mazzanti; R E Straub; D Goldman; D R Weinberger
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-29       Impact factor: 11.205

6.  COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor.

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7.  Selectivity as an Emotion Regulation Strategy: Lessons from Older Adults.

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8.  COMT but not serotonin-related genes modulates the influence of childhood abuse on anger traits.

Authors:  N Perroud; I Jaussent; S Guillaume; F Bellivier; P Baud; F Jollant; M Leboyer; C M Lewis; A Malafosse; P Courtet
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Review 10.  Gene × environment interaction studies have not properly controlled for potential confounders: the problem and the (simple) solution.

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Journal:  Biol Psychiatry       Date:  2013-10-15       Impact factor: 13.382
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3.  A Re-evaluation of Candidate Gene Studies for Well-Being in Light of Genome-Wide Evidence.

Authors:  Margot P van de Weijer; Dirk H M Pelt; Lianne P de Vries; Bart M L Baselmans; Meike Bartels
Journal:  J Happiness Stud       Date:  2022-05-17
  3 in total

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