Annika Karch1, Claus Vogelmeier2, Tobias Welte3, Robert Bals4, Hans-Ulrich Kauczor5, Jürgen Biederer5, Joachim Heinrich6, Holger Schulz6, Sven Gläser7, Rolf Holle8, Henrik Watz9, Stephanie Korn10, Nina Adaskina1, Frank Biertz1, Charlotte Vogel1, Jørgen Vestbo11, Emiel F M Wouters12, Klaus Friedrich Rabe9, Sandra Söhler13, Armin Koch14, Rudolf A Jörres15. 1. Institute for Biostatistics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. 2. Department of Respiratory Medicine, University of Marburg, University Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research, Baldingerstraße, 35043 Marburg, Germany. 3. Clinic for Pneumology, Hannover Medical School, Member of the German Center for Lung Research, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. 4. Department of Internal Medicine V - Pulmonology, Allergology, Respiratory Intensive Care Medicine, Saarland University Hospital, Kirrberger Straße 1, 66424 Homburg, Germany. 5. Department of Diagnostic and Interventional Radiology, University of Heidelberg, Translational Lung Research Center (TLRC), Member of the German Center for Lung Research, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany. 6. Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Member of the German Center for Lung Research, Comprehensive Pneumology Center Munich (CPC-M), Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany. 7. Department of Internal Medicine B - Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, University Medicine Greifswald, Scientific Division of Pneumology and Pneumological Epidemiology, Ferdinand-Sauerbruch-Strasse, 17475 Greifswald, Germany. 8. Institute of Health Economics and Health Care Management, Helmholtz Zentrum München (GmbH), German Research Center for Environmental Health, Member of the German Center for Lung Research, Comprehensive Pneumology Center Munich (CPC-M), Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany. 9. LungenClinic Grosshansdorf, Pulmonary Research Institute, Airway Research Center North, Member of the German Center for Lung Research, Woehrendamm 80, 22927 Grosshansdorf, Germany. 10. Pulmonary Department, Mainz University Hospital, Langenbeckstrasse 1, 55131 Mainz, Germany. 11. Centre for Respiratory Medicine and Allergy, Institute for Inflammation and Repair, University of Manchester, Southmoor Rd, Manchester M23 9LT, UK. 12. Department of Respiratory Medicine, Maastricht University Medical Center, P. Debyelaan 25, 6202 AZ Maastricht, The Netherlands. 13. ASCONET Study Coordination Office, University of Marburg, Baldingerstraße, 35043 Marburg, Germany. 14. Institute for Biostatistics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. Electronic address: koch.armin@mh-hannover.de. 15. Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität München, Ziemssenstr. 1, 80336 Munich, Germany. Electronic address: rudolf.joerres@med.uni-muenchen.de.
Abstract
BACKGROUND: The German COPD cohort study COSYCONET ("COPD and SYstemic consequences-COmorbidities NETwork") investigates the interaction of lung disease, comorbidities and systemic inflammation. Recruitment took place from 2010 to 2013 in 31 study centers. In addition to the baseline visit, follow-up visits are scheduled at 6, 18, 36 and 54 months after baseline. The study also comprises a biobank, image bank, and includes health economic data. Here we describe the study design of COSYCONET and present baseline data of our COPD cohort. METHODS: Inclusion criteria were broad in order to cover a wide range of patterns of the disease. In each visit, patients undergo a large panel of assessments including e.g. clinical history, spirometry, body plethysmography, diffusing capacity, blood samples, 6-min walk-distance, electrocardiogram and echocardiography. Chest CTs are collected if available and CTs and MRIs are performed in a subcohort. Data are entered into eCRFs and subjected to several stages of quality control. RESULTS: Overall, 2741 subjects with a clinical diagnosis of COPD were included (59% male; mean age 65 ± 8.6 years (range 40-90)). Of these, 8/35/32/9% presented with GOLD stages I-IV; 16% were uncategorized, including the former GOLD-0 category. 24% were active smokers, 68% ex-smokers and 8% never-smokers. Data completeness was 96% for the baseline items. CONCLUSION: The German COPD cohort comprises patients with advanced and less advanced COPD. This is particularly useful for studying the time course of COPD in relation to comorbidities. Baseline data indicate that COSYCONET offers the opportunity to investigate our research questions in a large-scale, high-quality dataset.
BACKGROUND: The German COPD cohort study COSYCONET ("COPD and SYstemic consequences-COmorbidities NETwork") investigates the interaction of lung disease, comorbidities and systemic inflammation. Recruitment took place from 2010 to 2013 in 31 study centers. In addition to the baseline visit, follow-up visits are scheduled at 6, 18, 36 and 54 months after baseline. The study also comprises a biobank, image bank, and includes health economic data. Here we describe the study design of COSYCONET and present baseline data of our COPD cohort. METHODS: Inclusion criteria were broad in order to cover a wide range of patterns of the disease. In each visit, patients undergo a large panel of assessments including e.g. clinical history, spirometry, body plethysmography, diffusing capacity, blood samples, 6-min walk-distance, electrocardiogram and echocardiography. Chest CTs are collected if available and CTs and MRIs are performed in a subcohort. Data are entered into eCRFs and subjected to several stages of quality control. RESULTS: Overall, 2741 subjects with a clinical diagnosis of COPD were included (59% male; mean age 65 ± 8.6 years (range 40-90)). Of these, 8/35/32/9% presented with GOLD stages I-IV; 16% were uncategorized, including the former GOLD-0 category. 24% were active smokers, 68% ex-smokers and 8% never-smokers. Data completeness was 96% for the baseline items. CONCLUSION: The German COPD cohort comprises patients with advanced and less advanced COPD. This is particularly useful for studying the time course of COPD in relation to comorbidities. Baseline data indicate that COSYCONET offers the opportunity to investigate our research questions in a large-scale, high-quality dataset.
Authors: Kathrin Kahnert; Johanna I Lutter; Tobias Welte; Peter Alter; Jürgen Behr; Felix Herth; Hans-Ulrich Kauczor; Sandra Söhler; Michael Pfeifer; Henrik Watz; Claus F Vogelmeier; Robert Bals; Rudolf A Jörres; Franziska C Trudzinski Journal: ERJ Open Res Date: 2021-08-23
Authors: Franziska C Trudzinski; Rudolf A Jörres; Peter Alter; Julia Walter; Henrik Watz; Andrea Koch; Matthias John; Marek Lommatzsch; Claus F Vogelmeier; Hans-Ulrich Kauczor; Tobias Welte; Jürgen Behr; Amanda Tufman; Robert Bals; Felix J F Herth; Kathrin Kahnert Journal: Sci Rep Date: 2022-05-24 Impact factor: 4.996
Authors: Jana Graf; Rudolf A Jörres; Tanja Lucke; Dennis Nowak; Claus F Vogelmeier; Joachim H Ficker Journal: Dtsch Arztebl Int Date: 2018-09-14 Impact factor: 5.594
Authors: Michael Seimetz; Natascha Sommer; Mariola Bednorz; Oleg Pak; Christine Veith; Stefan Hadzic; Marija Gredic; Nirmal Parajuli; Baktybek Kojonazarov; Simone Kraut; Jochen Wilhelm; Fenja Knoepp; Ingrid Henneke; Alexandra Pichl; Zeki I Kanbagli; Susan Scheibe; Athanasios Fysikopoulos; Cheng-Yu Wu; Walter Klepetko; Peter Jaksch; Christina Eichstaedt; Ekkehard Grünig; Katrin Hinderhofer; Miklós Geiszt; Niklas Müller; Flavia Rezende; Giulia Buchmann; Ilka Wittig; Matthias Hecker; Andreas Hecker; Winfried Padberg; Peter Dorfmüller; Stefan Gattenlöhner; Claus F Vogelmeier; Andreas Günther; Srikanth Karnati; Eveline Baumgart-Vogt; Ralph T Schermuly; Hossein A Ghofrani; Werner Seeger; Katrin Schröder; Friedrich Grimminger; Ralf P Brandes; Norbert Weissmann Journal: Nat Metab Date: 2020-06-08
Authors: Margarethe E Wacker; Rudolf A Jörres; Annika Karch; Sarah Wilke; Joachim Heinrich; Stefan Karrasch; Armin Koch; Holger Schulz; Henrik Watz; Reiner Leidl; Claus Vogelmeier; Rolf Holle Journal: BMC Pulm Med Date: 2016-05-10 Impact factor: 3.317
Authors: Margarethe E Wacker; Rudolf A Jörres; Annika Karch; Armin Koch; Joachim Heinrich; Stefan Karrasch; Holger Schulz; Annette Peters; Sven Gläser; Ralf Ewert; Sebastian E Baumeister; Claus Vogelmeier; Reiner Leidl; Rolf Holle Journal: Respir Res Date: 2016-07-12