Eleonora Lacorte1, Luigina Ferrigno2, Emanuele Leoncini3, Massimo Corbo4, Stefania Boccia5, Nicola Vanacore6. 1. National Center for Epidemiology, Surveillance and Health Promotion, National Institute of Health, via Giano della Bella 34, 00162 Rome, Italy. Electronic address: eleonora.lacorte@iss.it. 2. National Center for Epidemiology, Surveillance and Health Promotion, National Institute of Health, via Giano della Bella 34, 00162 Rome, Italy. Electronic address: luigina.ferrigno@iss.it. 3. Institute of Public Health, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli, 8, 00168 Rome, Italy. Electronic address: emanuele.leoncini@rm.unicatt.it. 4. Department of Neurorehabilitation Sciences, Casa Cura Policlinico (CCP), Via Giuseppe Dezza, 48, 20144, Milan, Italy. Electronic address: m.corbo@ccppdezza.it. 5. Institute of Public Health, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli, 8, 00168 Rome, Italy. Electronic address: sboccia@rm.unicatt.it. 6. National Center for Epidemiology, Surveillance and Health Promotion, National Institute of Health, via Giano della Bella 34, 00162 Rome, Italy. Electronic address: nicola.vanacore@iss.it.
Abstract
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is considered a multifactorial, multisystem neurodegenerative disease due to an interaction between environmental and genetic factors. This systematic review aims at gathering all available evidence on the association between physical activity (PA) and the risk of ALS. METHODS: Relevant literature published up to January 2015 was gathered through structured searches on Medline, The Cochrane Library, and the ISI Web of Science databases. Studies considering any type of PA as the main exposure and a diagnosis of ALS or motor neuron disease were selected. Data were extracted in standardized forms, and the quality of included studies was assessed using the Newcastle-Ottawa Scale (NOS). RESULTS: Bibliographic searches yielded 3168 records. Nineteen case control studies and 7 cohort studies met the inclusion criteria, and were included in the analysis. Evidence on cumulative measures of PA as a risk factor for ALS remain inconclusive. However, cohort studies report a significantly higher number of cases of ALS in professional soccer and American football players, and a slightly increased risk of ALS in varsity athletes.
BACKGROUND:Amyotrophic lateral sclerosis (ALS) is considered a multifactorial, multisystem neurodegenerative disease due to an interaction between environmental and genetic factors. This systematic review aims at gathering all available evidence on the association between physical activity (PA) and the risk of ALS. METHODS: Relevant literature published up to January 2015 was gathered through structured searches on Medline, The Cochrane Library, and the ISI Web of Science databases. Studies considering any type of PA as the main exposure and a diagnosis of ALS or motor neuron disease were selected. Data were extracted in standardized forms, and the quality of included studies was assessed using the Newcastle-Ottawa Scale (NOS). RESULTS: Bibliographic searches yielded 3168 records. Nineteen case control studies and 7 cohort studies met the inclusion criteria, and were included in the analysis. Evidence on cumulative measures of PA as a risk factor for ALS remain inconclusive. However, cohort studies report a significantly higher number of cases of ALS in professional soccer and American football players, and a slightly increased risk of ALS in varsity athletes.
Authors: Colin K Franz; Divya Joshi; Elizabeth L Daley; Rogan A Grant; Kyriakos Dalamagkas; Audrey Leung; John D Finan; Evangelos Kiskinis Journal: J Neurophysiol Date: 2019-05-22 Impact factor: 2.714
Authors: Elena Obrador; Rosario Salvador-Palmer; Rafael López-Blanch; Ali Jihad-Jebbar; Soraya L Vallés; José M Estrela Journal: Int J Mol Sci Date: 2021-06-14 Impact factor: 5.923