Literature DB >> 27100566

Self-Assembly Protein Nanogels for Safer Cancer Immunotherapy.

Alberto Purwada1, Ye F Tian2, Weishan Huang3, Kathleen M Rohrbach4, Simrita Deol3, Avery August3, Ankur Singh2.   

Abstract

Soluble antigen-based cancer vaccines have poor retention in tissues along with suboptimal antigen processing by dendritic cells. Multiple booster doses are often needed, leading to dose-limiting systemic toxicity. A versatile, immunomodulatory, self-assembly protein nanogel vaccine is reported that induces robust immune cell response at lower antigen doses than soluble antigens, an important step towards biomaterials-based safer immunotherapy approaches.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  T cell; antigen; immunomodulation; immunotherapy; nanogels

Mesh：

Substances：

Year:  2016        PMID： 27100566      PMCID： PMC5532174          DOI： 10.1002/adhm.201501062

Source DB:  PubMed          Journal:  Adv Healthc Mater        ISSN： 2192-2640            Impact factor:   9.933


  37 in total

1.  Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses.

Authors:  Seung-Yong Seong; Polly Matzinger
Journal:  Nat Rev Immunol       Date:  2004-06       Impact factor: 53.106

2.  New therapies for castration-resistant prostate cancer.

Authors:  Dan L Longo
Journal:  N Engl J Med       Date:  2010-07-29       Impact factor: 91.245

3.  Nanoengineered particles for enhanced intra-articular retention and delivery of proteins.

Authors:  Ankur Singh; Rachit Agarwal; Carlos A Diaz-Ruiz; Nick J Willett; Peiyi Wang; L Andrew Lee; Qian Wang; Robert E Guldberg; Andrés J García
Journal:  Adv Healthc Mater       Date:  2014-03-31       Impact factor: 9.933

Review 4.  Hydrogels and scaffolds for immunomodulation.

Authors:  Ankur Singh; Nicholas A Peppas
Journal:  Adv Mater       Date:  2014-08-25       Impact factor: 30.849

5.  Exploiting lymphatic transport and complement activation in nanoparticle vaccines.

Authors:  Sai T Reddy; André J van der Vlies; Eleonora Simeoni; Veronique Angeli; Gwendalyn J Randolph; Conlin P O'Neil; Leslie K Lee; Melody A Swartz; Jeffrey A Hubbell
Journal:  Nat Biotechnol       Date:  2007-09-16       Impact factor: 54.908

6.  In-situ crosslinking hydrogels for combinatorial delivery of chemokines and siRNA-DNA carrying microparticles to dendritic cells.

Authors:  Ankur Singh; Shalu Suri; Krishnendu Roy
Journal:  Biomaterials       Date:  2009-06-27       Impact factor: 12.479

7.  Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling.

Authors:  Bumsuk Hahm; Matthew J Trifilo; Elina I Zuniga; Michael B A Oldstone
Journal:  Immunity       Date:  2005-02       Impact factor: 31.745

8.  Endogenous dendritic cells are required for amplification of T cell responses induced by dendritic cell vaccines in vivo.

Authors:  Petra Kleindienst; Thomas Brocker
Journal:  J Immunol       Date:  2003-03-15       Impact factor: 5.422

Review 9.  Understanding the biology of antigen cross-presentation for the design of vaccines against cancer.

Authors:  Cynthia M Fehres; Wendy W J Unger; Juan J Garcia-Vallejo; Yvette van Kooyk
Journal:  Front Immunol       Date:  2014-04-08       Impact factor: 7.561

10.  Hydrogel containing nanoparticle-stabilized liposomes for topical antimicrobial delivery.

Authors:  Weiwei Gao; Drew Vecchio; Jieming Li; Jingying Zhu; Qiangzhe Zhang; Victoria Fu; Jiayang Li; Soracha Thamphiwatana; Diannan Lu; Liangfang Zhang
Journal:  ACS Nano       Date:  2014-02-05       Impact factor: 15.881
View more
  12 in total

1.  Alterations to the Gut Microbiome Impair Bone Strength and Tissue Material Properties.

Authors:  Jason D Guss; Michael W Horsfield; Fernanda F Fontenele; Taylor N Sandoval; Marysol Luna; Fnu Apoorva; Svetlana F Lima; Rodrigo C Bicalho; Ankur Singh; Ruth E Ley; Marjolein Ch van der Meulen; Steven R Goldring; Christopher J Hernandez
Journal:  J Bone Miner Res       Date:  2017-03-27       Impact factor: 6.741

Review 2.  Biomaterials for vaccine-based cancer immunotherapy.

Authors:  Rui Zhang; Margaret M Billingsley; Michael J Mitchell
Journal:  J Control Release       Date:  2018-10-09       Impact factor: 9.776

Review 3.  Advances in engineering local drug delivery systems for cancer immunotherapy.

Authors:  Peter Abdou; Zejun Wang; Qian Chen; Amanda Chan; Daojia R Zhou; Vivienne Gunadhi; Zhen Gu
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2020-04-07

Review 4.  Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment.

Authors:  Guoyou Huang; Fei Li; Xin Zhao; Yufei Ma; Yuhui Li; Min Lin; Guorui Jin; Tian Jian Lu; Guy M Genin; Feng Xu
Journal:  Chem Rev       Date:  2017-10-09       Impact factor: 60.622

5.  Self-Assembly as a Molecular Strategy to Improve Immunotherapy.

Authors:  Eugene Froimchuk; Sean T Carey; Camilla Edwards; Christopher M Jewell
Journal:  Acc Chem Res       Date:  2020-10-19       Impact factor: 22.384

6.  Biomimetic Nanoparticle Vaccines for Cancer Therapy.

Authors:  Ashley V Kroll; Yao Jiang; Jiarong Zhou; Maya Holay; Ronnie H Fang; Liangfang Zhang
Journal:  Adv Biosyst       Date:  2018-11-13

Review 7.  Protein-Based Nanohydrogels for Bioactive Delivery.

Authors:  Subhash Chander; Giriraj T Kulkarni; Neerupma Dhiman; Harsha Kharkwal
Journal:  Front Chem       Date:  2021-07-09       Impact factor: 5.221

Review 8.  The era of bioengineering: how will this affect the next generation of cancer immunotherapy?

Authors:  Michele Graciotti; Cristiana Berti; Harm-Anton Klok; Lana Kandalaft
Journal:  J Transl Med       Date:  2017-06-19       Impact factor: 5.531

Review 9.  Engineering self-assembled materials to study and direct immune function.

Authors:  Lisa H Tostanoski; Christopher M Jewell
Journal:  Adv Drug Deliv Rev       Date:  2017-04-06       Impact factor: 15.470

10.  Self-assembled peptide and protein nanostructures for anti-cancer therapy: Targeted delivery, stimuli-responsive devices and immunotherapy.

Authors:  Masoud Delfi; Rossella Sartorius; Milad Ashrafizadeh; Esmaeel Sharifi; Yapei Zhang; Piergiuseppe De Berardinis; Ali Zarrabi; Rajender S Varma; Franklin R Tay; Bryan Ronain Smith; Pooyan Makvandi
Journal:  Nano Today       Date:  2021-03-11       Impact factor: 18.962
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.