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Literature DB >> 24687997

Nanoengineered particles for enhanced intra-articular retention and delivery of proteins.

Ankur Singh¹, Rachit Agarwal, Carlos A Diaz-Ruiz, Nick J Willett, Peiyi Wang, L Andrew Lee, Qian Wang, Robert E Guldberg, Andrés J García.

Abstract

Localized intra-articular delivery of anti-inflammatory proteins can reduce inflammation in osteoarthritis but poses a challenge because of raid clearance within few hours of injection. A new class of polymer is developed that forms self-assembled nanoparticles ranging from 300 to 900 nm and demonstrates particle size dependent prolonged retention in intra-articular joint spaces compared to bolus protein over a period of 14 d.

Entities: CellLine Chemical Disease Gene Species

Keywords: biomaterials; nanoparticles; osteoarthritis; protein delivery

Mesh：

Substances：

Year: 2014 PMID： 24687997 PMCID： PMC4182168 DOI： 10.1002/adhm.201400051

Source DB: PubMed Journal: Adv Healthc Mater ISSN： 2192-2640 Impact factor: 9.933

32 in total

Review 1. Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets.

Authors: J P Pelletier; J Martel-Pelletier; S B Abramson
Journal: Arthritis Rheum Date: 2001-06

2. Self-assembly and cross-linking of bionanoparticles at liquid-liquid interfaces.

Authors: Justin T Russell; Yao Lin; Alexander Böker; Long Su; Philippe Carl; Heiko Zettl; Jinbo He; Kevin Sill; Ravisubhash Tangirala; Todd Emrick; Kenneth Littrell; Pappannan Thiyagarajan; David Cookson; Andreas Fery; Qian Wang; Thomas P Russell
Journal: Angew Chem Int Ed Engl Date: 2005-04-15 Impact factor: 15.336

3. Controlled assembly of rodlike viruses with polymers.

Authors: Tao Li; Laying Wu; Nisaraporn Suthiwangcharoen; Michael A Bruckman; Dayton Cash; Joan S Hudson; Soumitra Ghoshroy; Qian Wang
Journal: Chem Commun (Camb) Date: 2009-04-06 Impact factor: 6.222

4. Amelioration of rat antigen-induced arthritis by liposomally conjugated methotrexate is accompanied by down-regulation of cytokine mRNA expression.

Authors: A S Williams; N Topley; S Dojcinov; P J Richards; B D Williams
Journal: Rheumatology (Oxford) Date: 2001-04 Impact factor: 7.580

5. Size-dependency of DL-lactide/glycolide copolymer particulates for intra-articular delivery system on phagocytosis in rat synovium.

Authors: Eijiro Horisawa; Katsuaki Kubota; Izumi Tuboi; Keiichi Sato; Hiromitsu Yamamoto; Hirofumi Takeuchi; Yoshiaki Kawashima
Journal: Pharm Res Date: 2002-02 Impact factor: 4.200

Review 6. Liposomes as carriers of anti-inflammatory steroids.

Authors: C G Knight; I H Shaw
Journal: Front Biol Date: 1979

7. Effects of interleukin-1 receptor antagonist in a slow-release hylan vehicle on rat type II collagen arthritis.

Authors: A Bendele; T McAbee; M Woodward; J Scherrer; D Collins; J Frazier; E Chlipala; D McCabe
Journal: Pharm Res Date: 1998-10 Impact factor: 4.200

Review 8. Osteoarthritis, angiogenesis and inflammation.

Authors: C S Bonnet; D A Walsh
Journal: Rheumatology (Oxford) Date: 2004-08-03 Impact factor: 7.580

9. Intra-articular treatment of arthritis with microsphere formulations of paclitaxel: biocompatibility and efficacy determinations in rabbits.

Authors: R T Liggins; T Cruz; W Min; L Liang; W L Hunter; H M Burt
Journal: Inflamm Res Date: 2004-08-10 Impact factor: 4.575

10. Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors.

Authors: Florence Schaffner; Anne Marie Ray; Monique Dontenwill
Journal: Cancers (Basel) Date: 2013-01-15 Impact factor: 6.639

29 in total

Review 1. Hydrogels and scaffolds for immunomodulation.

Authors: Ankur Singh; Nicholas A Peppas
Journal: Adv Mater Date: 2014-08-25 Impact factor: 30.849

2. Articular Cartilage- and Synoviocyte-Binding Poly(ethylene glycol) Nanocomposite Microgels as Intra-Articular Drug Delivery Vehicles for the Treatment of Osteoarthritis.

Authors: Lina M Mancipe Castro; Abigail Sequeira; Andrés J García; Robert E Guldberg
Journal: ACS Biomater Sci Eng Date: 2020-08-28

Nanoengineered particles for enhanced intra-articular retention and delivery of proteins.

Review 1. Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets.

2. Self-assembly and cross-linking of bionanoparticles at liquid-liquid interfaces.

3. Controlled assembly of rodlike viruses with polymers.

4. Amelioration of rat antigen-induced arthritis by liposomally conjugated methotrexate is accompanied by down-regulation of cytokine mRNA expression.

5. Size-dependency of DL-lactide/glycolide copolymer particulates for intra-articular delivery system on phagocytosis in rat synovium.

Review 6. Liposomes as carriers of anti-inflammatory steroids.

7. Effects of interleukin-1 receptor antagonist in a slow-release hylan vehicle on rat type II collagen arthritis.

Review 8. Osteoarthritis, angiogenesis and inflammation.

9. Intra-articular treatment of arthritis with microsphere formulations of paclitaxel: biocompatibility and efficacy determinations in rabbits.

10. Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors.

Review 1. Hydrogels and scaffolds for immunomodulation.

2. Articular Cartilage- and Synoviocyte-Binding Poly(ethylene glycol) Nanocomposite Microgels as Intra-Articular Drug Delivery Vehicles for the Treatment of Osteoarthritis.

3. Self-Assembly Protein Nanogels for Safer Cancer Immunotherapy.

Review 4. Particle-based technologies for osteoarthritis detection and therapy.

5. The clearance and biodistribution of magnetic composite nanoparticles in healthy and osteoarthritic rat knees.

Review 6. Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment.

7. Mechanobiological Mechanisms of Load-Induced Osteoarthritis in the Mouse Knee.

8. Self-assembled, ellipsoidal polymeric nanoparticles for intracellular delivery of therapeutics.

9. Biomimetic Nanoparticle Vaccines for Cancer Therapy.

10. Engineering immunomodulatory biomaterials for type 1 diabetes.