Artjoms Spaks1, Darja Svirina2, Irina Spaka3, Inta Jaunalksne4, Donats Breiva1, Ilmars Tracums1, Dainis Krievins5,6. 1. a Department of Thoracic Surgery , Pauls Stradins Clinical University Hospital , Riga , Latvia ; 2. b Department of Pathology , University of Latvia , Riga , Latvia ; 3. c Department of Molecular Biology , Riga Stradins University , Riga , Latvia ; 4. d Department of Clinical Immunology , Pauls Stradins Clinical University Hospital , Riga , Latvia ; 5. e Department of Vascular Surgery , Pauls Stradins Clinical University Hospital , Riga , Latvia ; 6. f University of Latvia, Faculty of Medicine , Riga , Latvia.
Abstract
OBJECTIVE: To evaluate the association of CXC chemokine ligand 4 (CXCL4) plasma levels with tumour angiogenesis in non-small cell lung cancer (NSCLC) and to assess association of CXCL4 with clinical outcomes. PATIENTS AND METHODS: Fifty patients with early stage NSCLC who underwent pulmonary resection. CXCL4 levels were analysed by ELISA. Angiogenesis was assessed by immunohistochemistry, and microvessel density (MVD) count. RESULTS: There was positive correlation between MVD and CXCL4 levels. Patients with higher CXCL4 levels had worse overall and disease-free survival. CONCLUSIONS: Plasma levels of CXCL4 are associated with tumour vascularity. Increased CXCL4 levels in NSCLC patients undergoing treatment may indicate active cancer-induced angiogenesis associated with relapse and worse outcome.
OBJECTIVE: To evaluate the association of CXC chemokine ligand 4 (CXCL4) plasma levels with tumour angiogenesis in non-small cell lung cancer (NSCLC) and to assess association of CXCL4 with clinical outcomes. PATIENTS AND METHODS: Fifty patients with early stage NSCLC who underwent pulmonary resection. CXCL4 levels were analysed by ELISA. Angiogenesis was assessed by immunohistochemistry, and microvessel density (MVD) count. RESULTS: There was positive correlation between MVD and CXCL4 levels. Patients with higher CXCL4 levels had worse overall and disease-free survival. CONCLUSIONS: Plasma levels of CXCL4 are associated with tumour vascularity. Increased CXCL4 levels in NSCLCpatients undergoing treatment may indicate active cancer-induced angiogenesis associated with relapse and worse outcome.
Authors: Ricardo J Flores; Aaron J Kelly; Yiting Li; Xiang Chen; Colin McGee; Mark Krailo; Donald A Barkauskas; John Hicks; Tsz-Kwong Man Journal: Pediatr Blood Cancer Date: 2017-05-24 Impact factor: 3.167
Authors: Sassine Ghanem; Sandy El Bitar; Sami Hossri; Chanudi Weerasinghe; Jean Paul Atallah Journal: Cancer Manag Res Date: 2017-07-06 Impact factor: 3.989