BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with an increased risk of colorectal cancer (CRC); however, studies differentiating between subsites of CRC are limited. We investigated how diabetes mellitus (DM) was associated with subsite-specific CRC risk in men and women. METHODS: The Netherlands Cohort Study on diet and cancer is a prospective study among 120 852 men and women aged 55-69 years old at baseline in 1986. Information on DM, anthropometric, dietary and lifestyle factors was self-reported at baseline. T2DM was defined as the diagnosis of DM after 30 years of age. Incident CRC cases were identified by record linkage with the Netherlands cancer registry and the Dutch pathology registry. After 17.3 years of follow-up, 1735 incident male CRC cases and 1321 female CRC cases were available for analyses. Subsite-specific hazard ratios (HRs) for CRC were estimated in case-cohort analyses using Cox regression. RESULTS: At baseline, 3.1% of subcohort members reported T2DM, of whom 80% were diagnosed after 50 years of age. Multivariable-adjusted models showed that the risk of proximal colon cancer was significantly increased in women with T2DM versus women without T2DM (HR=1.80, 95% confidence interval: 1.10-2.94). There was no association between T2DM and the risk of overall CRC, distal colon cancer and rectal cancer in women. In men, T2DM was not associated with overall CRC (HR=0.98, 95% confidence interval: 0.64-1.50), or with risk at any subsite. CONCLUSIONS: This prospective study showed an increased risk of proximal colon cancer in women with T2DM compared with non-T2DM women.
BACKGROUND:Type 2 diabetes mellitus (T2DM) is associated with an increased risk of colorectal cancer (CRC); however, studies differentiating between subsites of CRC are limited. We investigated how diabetes mellitus (DM) was associated with subsite-specific CRC risk in men and women. METHODS: The Netherlands Cohort Study on diet and cancer is a prospective study among 120 852 men and women aged 55-69 years old at baseline in 1986. Information on DM, anthropometric, dietary and lifestyle factors was self-reported at baseline. T2DM was defined as the diagnosis of DM after 30 years of age. Incident CRC cases were identified by record linkage with the Netherlands cancer registry and the Dutch pathology registry. After 17.3 years of follow-up, 1735 incident male CRC cases and 1321 female CRC cases were available for analyses. Subsite-specific hazard ratios (HRs) for CRC were estimated in case-cohort analyses using Cox regression. RESULTS: At baseline, 3.1% of subcohort members reported T2DM, of whom 80% were diagnosed after 50 years of age. Multivariable-adjusted models showed that the risk of proximal colon cancer was significantly increased in women with T2DM versus women without T2DM (HR=1.80, 95% confidence interval: 1.10-2.94). There was no association between T2DM and the risk of overall CRC, distal colon cancer and rectal cancer in women. In men, T2DM was not associated with overall CRC (HR=0.98, 95% confidence interval: 0.64-1.50), or with risk at any subsite. CONCLUSIONS: This prospective study showed an increased risk of proximal colon cancer in women with T2DM compared with non-T2DM women.
Authors: Elisa de Paula França Resende; Luciana Costa-Silva; Karoline Carvalho Carmona; Thais Helena Machado; João Carlos Barbosa Machado; Henrique Cerqueira Guimarães; Maira Tonidandel Barbosa; Antônio Lúcio Teixeira; Leonardo Cruz de Souza; Paulo Caramelli Journal: eNeurologicalSci Date: 2016-12-01
Authors: Nieves González; Isabel Prieto; Laura Del Puerto-Nevado; Sergio Portal-Nuñez; Juan Antonio Ardura; Marta Corton; Beatriz Fernández-Fernández; Oscar Aguilera; Carmen Gomez-Guerrero; Sebastián Mas; Juan Antonio Moreno; Marta Ruiz-Ortega; Ana Belen Sanz; Maria Dolores Sanchez-Niño; Federico Rojo; Fernando Vivanco; Pedro Esbrit; Carmen Ayuso; Gloria Alvarez-Llamas; Jesús Egido; Jesús García-Foncillas; Alberto Ortiz Journal: Oncotarget Date: 2017-03-14
Authors: Isabel Prieto; Laura Del Puerto-Nevado; Nieves Gonzalez; Sergio Portal-Nuñez; Sandra Zazo; Marta Corton; Pablo Minguez; Carmen Gomez-Guerrero; Jose Miguel Arce; Ana Belen Sanz; Sebastian Mas; Oscar Aguilera; Gloria Alvarez-Llamas; Pedro Esbrit; Alberto Ortiz; Carmen Ayuso; Jesus Egido; Federico Rojo; Jesus Garcia-Foncillas Journal: PLoS One Date: 2017-03-02 Impact factor: 3.240
Authors: Yanan Ma; Wanshui Yang; Mingyang Song; Stephanie A Smith-Warner; Juhong Yang; Yanping Li; Wenjie Ma; Yang Hu; Shuji Ogino; Frank B Hu; Deliang Wen; Andrew T Chan; Edward L Giovannucci; Xuehong Zhang Journal: Br J Cancer Date: 2018-11-07 Impact factor: 7.640
Authors: Jiao Yang; Xiang Lin Du; Shu Ting Li; Bi Yuan Wang; Yin Ying Wu; Zhe Ling Chen; Meng Lv; Yan Wei Shen; Xin Wang; Dan Feng Dong; Dan Li; Fan Wang; En Xiao Li; Min Yi; Jin Yang Journal: PLoS One Date: 2016-12-09 Impact factor: 3.240