| Literature DB >> 27096164 |
Tânia S Morais1,2, Andreia Valente1, Ana Isabel Tomaz1, Fernanda Marques3, Maria Helena Garcia1.
Abstract
Research on the field of metal complexes for the treatment of cancer diseases has attracted increasing interest due to the urgency in finding more efficient and selective treatments. Owing to their wide structural diversity, organometallic complexes appear as potential alternatives to the design of new anticancer candidates. Herein, we review recent progress in our work toward the development of new drugs based on Ru(II)- and Fe(II)-cyclopentadienyl scaffolds. Their design and chemical properties are reviewed and correlated with their biological effects, in particular the key role that coligands play in the overall behavior of the complex.Entities:
Keywords: anticancer; cellular uptake; cyclopentadienyl; cytotoxicity; iron(II); molecular targets; organometallic; ruthenium(II)
Mesh：
Substances：
Year: 2016 PMID： 27096164 DOI： 10.4155/fmc.16.7
Source DB: PubMed Journal: Future Med Chem ISSN： 1756-8919 Impact factor: 3.808