Literature DB >> 27089051

Management of acute uncomplicated diverticulitis without antibiotics: a single-centre cohort study.

N D Brochmann1, J K Schultz2,3, G S Jakobsen1,4, T Øresland1,4.   

Abstract

AIM: This study aimed to evaluate the implementation of nonantibiotic management of acute uncomplicated diverticulitis at a large university hospital in Norway with regard to management failure, disease recurrence and complications.
METHOD: On 1 January 2013 we implemented a new policy for the management of acute uncomplicated diverticulitis without antibiotics. Antibiotic treatment was only provided in the case of defined criteria. All patients admitted from 1 January 2013 to 30 June 2014 with a CT-verified, left-sided, acute uncomplicated diverticulitis were included in the study and evaluated retrospectively, with 12 months' follow-up.
RESULTS: Of 244 admissions with acute uncomplicated diverticulitis, 177 (73%) were managed without antibiotics. Among these there were seven (4%) management failures, including five patients in whom a deteriorating clinical picture prompted antibiotic treatment and two readmissions within 1 month due to persisting symptoms. The only complication in this group was one fistula (< 1%). Eight (5%) patients had a recurrence of acute diverticulitis requiring hospital care and two (1%) underwent elective surgery within the first year. Twenty (8%) patients met predefined exemption criteria and received antibiotics from admission, six (30%) of whom developed complications. The recurrence rate in this group was 10% and none had surgery performed. The 47 (20%) policy violators treated with antibiotics from admission had no complications. Their recurrence rate was 11% and one (2%) patient underwent elective surgery.
CONCLUSION: This study confirms that nonantibiotic management of acute uncomplicated diverticulitis is safe and feasible. Most complications occurred in a small group of high-risk patients treated with antibiotics. Colorectal Disease
© 2016 The Association of Coloproctology of Great Britain and Ireland.

Entities:  

Keywords:  Diverticulitis; antibiotics; colonic; diverticular disease; nonantibiotic management

Mesh:

Substances:

Year:  2016        PMID: 27089051     DOI: 10.1111/codi.13355

Source DB:  PubMed          Journal:  Colorectal Dis        ISSN: 1462-8910            Impact factor:   3.788


  12 in total

1.  Multicentre, controlled, randomized clinical trial to compare the efficacy and safety of ambulatory treatment of mild acute diverticulitis without antibiotics with the standard treatment with antibiotics.

Authors:  Laura Mora Lopez; Neus Ruiz-Edo; Sheila Serra Pla; Anna Pallisera Llovera; Salvador Navarro Soto; Xavier Serra-Aracil
Journal:  Int J Colorectal Dis       Date:  2017-08-14       Impact factor: 2.571

Review 2.  Antibiotics in Uncomplicated Acute Diverticulitis: To Give or Not to Give?

Authors:  Mona Rezapour; Neil Stollman
Journal:  Inflamm Intest Dis       Date:  2018-07-20

Review 3.  Management of acute uncomplicated diverticulitis without antibiotics: a systematic review, meta-analysis, and meta-regression of predictors of treatment failure.

Authors:  S H Emile; H Elfeki; A Sakr; M Shalaby
Journal:  Tech Coloproctol       Date:  2018-07-06       Impact factor: 3.781

Review 4.  [Diverticulitis : Domain of conservative or drug therapy?]

Authors:  S Böhm; W Kruis
Journal:  Internist (Berl)       Date:  2017-07       Impact factor: 0.743

5.  Prospective randomized clinical trial of uncomplicated right-sided colonic diverticulitis: antibiotics versus no antibiotics.

Authors:  Jeong Yeon Kim; Sung Gil Park; Hee Joon Kang; Young Ah Lim; Kyung Ho Pak; Tae Yoo; Won Tae Cho; Dong Woo Shin; Jong Wan Kim
Journal:  Int J Colorectal Dis       Date:  2019-07-02       Impact factor: 2.571

Review 6.  Antibiotics for uncomplicated diverticulitis.

Authors:  Marie-Louise Dichman; Steffen Jais Rosenstock; Daniel M Shabanzadeh
Journal:  Cochrane Database Syst Rev       Date:  2022-06-22

7.  Low risk of complications in patients with first-time acute uncomplicated diverticulitis.

Authors:  Abbas Chabok; Kalle Andreasson; Maziar Nikberg
Journal:  Int J Colorectal Dis       Date:  2017-10-16       Impact factor: 2.571

Review 8.  Management of Acute Uncomplicated Diverticulitis May Exclude Antibiotic Therapy.

Authors:  Jonathan Mayl; Mikhail Marchenko; Emily Frierson
Journal:  Cureus       Date:  2017-05-15

9.  Treatment of acute uncomplicated diverticulitis without antibiotics: risk factors for treatment failure.

Authors:  H E Bolkenstein; W A Draaisma; Bjm van de Wall; Ecj Consten; Iamj Broeders
Journal:  Int J Colorectal Dis       Date:  2018-04-21       Impact factor: 2.571

Review 10.  Changing Paradigms in the Management of Acute Uncomplicated Diverticulitis.

Authors:  A Chabok; A Thorisson; M Nikberg; J K Schultz; V Sallinen
Journal:  Scand J Surg       Date:  2021-05-03       Impact factor: 2.360

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