Núria Piqué1, Marta Ponce2, Vicente Garrigues2, Luis Rodrigo3, Félix Calvo4, Carlos Martín de Argila5, Fernando Borda6, Antonio Naranjo7, Javier Alcedo8, María José Soria9, Enrique Rey10, Luis Bujanda11, Javier P Gisbert12, David Suarez13, Xavier Calvet14, Julio Ponce2. 1. Department of Microbiology and Parasitology, Pharmacy Faculty, Universitat de Barcelona, Spain. 2. Department of Gastroenterology, Hospital Universitario La Fe, Valencia, Spain. 3. Digestive Tract Department, Hospital Central de Asturias, Oviedo, Spain. 4. Department of Gastroenterology, Complejo Hospitalario Universitario de Albacete, Albacete, Spain. 5. Department of Gastroenterology, Hospital Universitario Ramón y Cajal, Madrid, Spain. 6. Service of Digestive Tract, Hospital de Navarra, Pamplona, Spain. 7. Gastroenterology and Hepatology Department, University Hospital Reina Sofia, Córdoba, Spain. 8. Gastroenterology and Hepatology, Hospital San Jorge, Huesca, Spain. 9. Department of Digestive Tract, Hospital Universitario Puerta del Mar, Cádiz, Spain. 10. Department of Digestive Tract, Hospital Clínico Universitario San Carlos, Madrid, Spain. 11. Department of Gastroenterology Hospital de Donostia, San Sebastian, Spain; Instituto Biodonostia (Universidad del País Vasco UPV/EHU), Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain. 12. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain; Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain. 13. Unitat d'Epidemiologia i Avaluació-Fundació Parc Taulí, Hospital de Sabadell, Institut Universitari Parc Taulí, Universitat Autónoma de Barcelona, Sabadell, Spain. 14. Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain; Department of Gastroenterology, Corporació Sanitaria Universitària Parc Taulí, Sabadell (Barcelona), Spain; Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain.
Abstract
BACKGROUND: *N.P. and M.P. contributed equally to this study.The current prevalence of esophagitis in southern Europe is unknown. In addition, the risk factors for reflux esophagitis are not fully understood. OBJECTIVE: The objective of this article is to assess the prevalence and risk factors for esophagitis in Spain. METHODS: A prospective, observational, cross-sectional, multicenter study (PRESS study) was conducted among 31 gastrointestinal endoscopy units throughout Spain. A total of 1361 patients undergoing upper gastrointestinal endoscopy were enrolled. Sociodemographic, clinical and treatment data were recorded. RESULTS: A total of 95% of patients were Caucasian and 52% were male (mean age: 53 ± 17 years). The most frequent symptoms prompting endoscopy were heartburn (40%), regurgitation (26%) and dysphagia (15%). Fifty-four percent of patients undergoing endoscopy were receiving proton pump inhibitor (PPI) treatment. Esophagitis (mainly mild-moderate) was present in 154 (12.4%) patients. The severe form was recorded in only 11 (0.8%) patients. Multivariate analysis results indicated that the likelihood of esophagitis was higher in men (OR = 1.91, 95% CI = 1.31-2.78), in patients with high GERD-Q scores (OR = 1.256, 95% CI = 1.176-1.343), weight increase (OR = 1.014, 95% CI = 1.003-1.025) and high alcohol consumption (OR = 2.49, 95% CI = 1.16-5.36). CONCLUSION: Severe esophagitis is a rare finding in the Spanish population. Male gender, high GERD-Q score, weight increase and high alcohol consumption are main risk factors for its appearance.
BACKGROUND: *N.P. and M.P. contributed equally to this study.The current prevalence of esophagitis in southern Europe is unknown. In addition, the risk factors for reflux esophagitis are not fully understood. OBJECTIVE: The objective of this article is to assess the prevalence and risk factors for esophagitis in Spain. METHODS: A prospective, observational, cross-sectional, multicenter study (PRESS study) was conducted among 31 gastrointestinal endoscopy units throughout Spain. A total of 1361 patients undergoing upper gastrointestinal endoscopy were enrolled. Sociodemographic, clinical and treatment data were recorded. RESULTS: A total of 95% of patients were Caucasian and 52% were male (mean age: 53 ± 17 years). The most frequent symptoms prompting endoscopy were heartburn (40%), regurgitation (26%) and dysphagia (15%). Fifty-four percent of patients undergoing endoscopy were receiving proton pump inhibitor (PPI) treatment. Esophagitis (mainly mild-moderate) was present in 154 (12.4%) patients. The severe form was recorded in only 11 (0.8%) patients. Multivariate analysis results indicated that the likelihood of esophagitis was higher in men (OR = 1.91, 95% CI = 1.31-2.78), in patients with high GERD-Q scores (OR = 1.256, 95% CI = 1.176-1.343), weight increase (OR = 1.014, 95% CI = 1.003-1.025) and high alcohol consumption (OR = 2.49, 95% CI = 1.16-5.36). CONCLUSION: Severe esophagitis is a rare finding in the Spanish population. Male gender, high GERD-Q score, weight increase and high alcohol consumption are main risk factors for its appearance.
Authors: Alberto Pilotto; Marilisa Franceschi; Gioacchino Leandro; Carlo Scarcelli; Luigi P D'Ambrosio; Davide Seripa; Francesco Perri; Valeria Niro; Francesco Paris; Angelo Andriulli; Francesco Di Mario Journal: J Am Geriatr Soc Date: 2006-10 Impact factor: 5.562
Authors: Elisabeth Scheidl; Claus Benz; Peter Loeff; Volker Groneck; Andreas König; Alban Schulte-Fischedick; Hendrik Lück; Uwe Fuhr Journal: Drugs R D Date: 2020-06