Literature DB >> 27087315

Thioether bond formation by SPASM domain radical SAM enzymes: Cα H-atom abstraction in subtilosin A biosynthesis.

Alhosna Benjdia1, Alain Guillot1, Benjamin Lefranc2, Hubert Vaudry2, Jérôme Leprince2, Olivier Berteau1.   

Abstract

AlbA is a radical SAM enzyme catalyzing the formation of three unusual thioether bonds in the antibiotic subtilosin A. We demonstrate here that AlbA catalyzes direct Cα H-atom abstraction and likely contains three essential [4Fe-4S] centers. This leads us to propose novel mechanistic perspectives for thioether bond catalysis by radical SAM enzymes.

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Year:  2016        PMID： 27087315     DOI： 10.1039/c6cc01317a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  29 in total

1.  Electron Paramagnetic Resonance Spectroscopic Identification of the Fe-S Clusters in the SPASM Domain-Containing Radical SAM Enzyme PqqE.

Authors:  Lizhi Tao; Wen Zhu; Judith P Klinman; R David Britt
Journal:  Biochemistry       Date:  2019-12-11       Impact factor: 3.162

2.  Mechanistic elucidation of the mycofactocin-biosynthetic radical S-adenosylmethionine protein, MftC.

Authors:  Bulat Khaliullin; Richard Ayikpoe; Mason Tuttle; John A Latham
Journal:  J Biol Chem       Date:  2017-06-20       Impact factor: 5.157

3.  X-ray and EPR Characterization of the Auxiliary Fe-S Clusters in the Radical SAM Enzyme PqqE.

Authors:  Ian Barr; Troy A Stich; Anthony S Gizzi; Tyler L Grove; Jeffrey B Bonanno; John A Latham; Tyler Chung; Carrie M Wilmot; R David Britt; Steven C Almo; Judith P Klinman
Journal:  Biochemistry       Date:  2018-02-06       Impact factor: 3.162

Review 4.  Oxidative Cyclization in Natural Product Biosynthesis.

Authors:  Man-Cheng Tang; Yi Zou; Kenji Watanabe; Christopher T Walsh; Yi Tang
Journal:  Chem Rev       Date:  2016-12-12       Impact factor: 60.622

5.  Reconstitution and Substrate Specificity of the Thioether-Forming Radical S-Adenosylmethionine Enzyme in Freyrasin Biosynthesis.

Authors:  Timothy W Precord; Nilkamal Mahanta; Douglas A Mitchell
Journal:  ACS Chem Biol       Date:  2019-09-09       Impact factor: 5.100

6.  SkfB Abstracts a Hydrogen Atom from Cα on SkfA To Initiate Thioether Cross-Link Formation.

Authors:  Nathan A Bruender; Vahe Bandarian
Journal:  Biochemistry       Date:  2016-07-21       Impact factor: 3.162

7.  Structural Properties and Catalytic Implications of the SPASM Domain Iron-Sulfur Clusters in Methylorubrum extorquens PqqE.

Authors:  Wen Zhu; Lindsey M Walker; Lizhi Tao; Anthony T Iavarone; Xuetong Wei; R David Britt; Sean J Elliott; Judith P Klinman
Journal:  J Am Chem Soc       Date:  2020-07-09       Impact factor: 15.419

8.  Structural Insights into Thioether Bond Formation in the Biosynthesis of Sactipeptides.

Authors:  Tyler L Grove; Paul M Himes; Sungwon Hwang; Hayretin Yumerefendi; Jeffrey B Bonanno; Brian Kuhlman; Steven C Almo; Albert A Bowers
Journal:  J Am Chem Soc       Date:  2017-08-21       Impact factor: 15.419

9.  Nuclear Magnetic Resonance Structure and Binding Studies of PqqD, a Chaperone Required in the Biosynthesis of the Bacterial Dehydrogenase Cofactor Pyrroloquinoline Quinone.

Authors:  Robert L Evans; John A Latham; Youlin Xia; Judith P Klinman; Carrie M Wilmot
Journal:  Biochemistry       Date:  2017-05-12       Impact factor: 3.162

10.  Bioinformatic Mapping of Radical S-Adenosylmethionine-Dependent Ribosomally Synthesized and Post-Translationally Modified Peptides Identifies New Cα, Cβ, and Cγ-Linked Thioether-Containing Peptides.

Authors:  Graham A Hudson; Brandon J Burkhart; Adam J DiCaprio; Christopher J Schwalen; Bryce Kille; Taras V Pogorelov; Douglas A Mitchell
Journal:  J Am Chem Soc       Date:  2019-05-13       Impact factor: 15.419
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