| Literature DB >> 27086703 |
Carlos Campos1,2, Nuno Barbosa F Rocha2, Eduardo Lattari1, Flávia Paes1, António E Nardi1, Sérgio Machado1,3.
Abstract
Age-related neurodegenerative disorders, like Alzheimer's or Parkinson's disease, are becoming a major issue to public health care. Currently, there is no effective pharmacological treatment to address cognitive impairment in these patients. Here, we aim to explore the role of exercise-induced trophic factor enhancement in the prevention or delay of cognitive decline in patients with neurodegenerative diseases. There is a significant amount of evidence from animal and human studies that links neurodegenerative related cognitive deficits with changes on brain and peripheral trophic factor levels. Several trials with elderly individuals and patients with neurodegenerative diseases report exercise induced cognitive improvements and changes on trophic factor levels including BDNF, IGF-I, among others. Further studies with healthy aging and clinical populations are needed to understand how diverse exercise interventions produce different variations in trophic factor signaling. Genetic profiles and potential confounders regarding trophic factors should also be addressed in future trials.Entities:
Keywords: Alzheimer’s disease; BDNF; Exercise; GDNF; IGF-I; NGF; Parkinson’s disease; neurodegenerative disease; neuroprotective; neurotrophins
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Year: 2016 PMID： 27086703 DOI： 10.1080/14737175.2016.1179582
Source DB: PubMed Journal: Expert Rev Neurother ISSN： 1473-7175 Impact factor: 4.618